The Future of Arrhythmias and Electrophysiology

Albert, Christine M.; Stevenson, William G.

doi:10.1161/circulationaha.116.023519

Cited by 19 publications

(22 citation statements)

References 81 publications

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“…Cardiac arrhythmias are a significant cause of morbidity and mortality [1]. The vast majority of arrhythmias occur in patients with underlying heart disease.…”

Section: Herg K+ Channels and Cardiac Arrhythmiasmentioning

confidence: 99%

Towards a Structural View of Drug Binding to hERG K + Channels

Vandenberg

Perozo

Allen

2017

Trends in Pharmacological Sciences

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The human ether-a-go-go-related gene (hERG) K channel is of great medical and pharmaceutical relevance. Inherited mutations in hERG result in congenital long-QT syndrome which is associated with a markedly increased risk of cardiac arrhythmia and sudden death. hERG K channels are also remarkably susceptible to block by a wide range of drugs, which in turn can cause drug-induced long-QT syndrome and an increased risk of sudden death. The recent determination of the near-atomic resolution structure of the hERG K channel, using single-particle cryo-electron microscopy (cryo-EM), provides tremendous insights into how these channels work. It also suggests a way forward in our quest to understand why these channels are so promiscuous with respect to drug binding.

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“…Cardiac arrhythmias are a significant cause of morbidity and mortality [1]. The vast majority of arrhythmias occur in patients with underlying heart disease.…”

Section: Herg K+ Channels and Cardiac Arrhythmiasmentioning

confidence: 99%

Towards a Structural View of Drug Binding to hERG K + Channels

Vandenberg

Perozo

Allen

2017

Trends in Pharmacological Sciences

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“…Catheter ablation has been well established in the treatment of a variety of tachyarrhythmias. 1 Such an anatomy-based therapy has placed high requirements on the precision of localization, stability of catheter contact, and catheter flexibility. Even experienced cardiac electrophysiologists performing certain ablation procedures may encounter difficulties in reaching complex anatomical regions and maintaining the stability of the catheter, leading to impaired safety and success rate.…”

Section: Introductionmentioning

confidence: 99%

“…Catheter ablation has been well established in the treatment of a variety of tachyarrhythmias 1 . Such an anatomy‐based therapy has placed high requirements on the precision of localization, stability of catheter contact, and catheter flexibility.…”

Section: Introductionmentioning

confidence: 99%

Procedural outcomes and learning curve of cardiac arrhythmias catheter ablation using remote magnetic navigation: Experience from a large‐scale single‐center study

Zhang

et al. 2020

Clinical Cardiology

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Background Remote magnetic navigation (RMN)‐guided ablation has become an inspiring method of catheter ablation for tachyarrhythmias. Hypothesis Data from a large‐scale single center may provide further insight into the safety of and the learning curve for RMN‐guided ablation. Methods A total of 1003 catheter ablation procedures using RMN for conditions including supraventricular ventricular tachycardia, atrial tachyarrhythmias, and premature ventricular contraction/ventricular tachycardia (PVC/VT) were retrospectively analyzed from an ablation registry. Procedural outcomes, including procedure time, mapping time, X‐ray time, and RF time, were assessed. The complications were classified into two categories: major and minor. A subanalysis was used to illustrate the learning curve of RMN‐guided ablation by assessing procedure time and total X‐ray time of 502 atrial fibrillation (AF) ablation procedures. Results Among these procedures, 556 (55.4%) were AF and 290 (28.9%) were PVC/VT. Electrical pulmonary vein isolation was achieved in 99.0% of AF procedures, and acute success reached 90.3% in PVC/VT procedures. The overall complication rate was 0.5%. In the subanalysis of AF procedures, the overall procedure time and X‐ray time of procedures were short (125.9 ± 54.6 and 5.3 ± 3.9 minutes, respectively) and proceeded to decrease from the initial 30 procedures to about 300 procedures, where the learning curve reached plateau, demonstrating maximum procedure efficiency. Conclusions RMN‐guided ablation is safe, as verified by very low overall complication rate and reduced X‐ray time. In our study, even the first AF procedures had a relatively low procedure time and total X‐ray time, and procedure efficiency improved during the learning curve.

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“…Sudden cardiac death (SCD) is an event of presumed cardiac origin occurring suddenly and unexpectedly in an otherwise stable patient [ 1 ]. From a healthcare perspective, with a rate as high as 183,000 deaths per year, SCD represents a major social issue [ 2 ]. Despite several improvements in the treatment of cardiovascular diseases, SCD still accounts for 2.04 million or 40–50% of the potential years of life lost [ 2 , 3 ].…”

Section: Introductionmentioning

confidence: 99%

Sudden Cardiac Death in Patients with Heart Disease and Preserved Systolic Function: Current Options for Risk Stratification

Pannone

Falasconi

Cianfanelli

et al. 2021

JCM

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Sudden cardiac death (SCD) is the leading cause of cardiovascular mortality in patients with coronary artery disease without severe systolic dysfunction and in heart failure with preserved ejection fraction. From a global health perspective, while risk may be lower, the absolute number of SCDs in patients with left ventricle ejection fraction >35% is higher than in those with severely reduced left ventricle ejection fraction (defined as ≤35%). Despite these observations and the high amount of available data, to date there are no clear recommendations to reduce the sudden cardiac death burden in the population with mid-range or preserved left ventricle ejection fraction. Ongoing improvements in risk stratification based on electrophysiological and imaging techniques point towards a more precise identification of patients who would benefit from ICD implantation, which is still an unmet need in this subset of patients. The aim of this review is to provide a state-of-the-art approach in sudden cardiac death risk stratification of patients with mid-range and preserved left ventricular ejection fraction and one of the following etiologies: ischemic cardiomyopathy, heart failure, atrial fibrillation or myocarditis.

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The Future of Arrhythmias and Electrophysiology

Cited by 19 publications

References 81 publications

Towards a Structural View of Drug Binding to hERG K + Channels

Towards a Structural View of Drug Binding to hERG K + Channels

Procedural outcomes and learning curve of cardiac arrhythmias catheter ablation using remote magnetic navigation: Experience from a large‐scale single‐center study

Sudden Cardiac Death in Patients with Heart Disease and Preserved Systolic Function: Current Options for Risk Stratification

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