Sudden Cardiac Death in Patients with Heart Disease and Preserved Systolic Function: Current Options for Risk Stratification

Pannone, Luigi; Falasconi, Giulio; Cianfanelli, Lorenzo; Baldetti, Luca; Moroni, Francesco; Spoladore, Roberto; Vergara, Pasquale

doi:10.3390/jcm10091823

Cited by 12 publications

(12 citation statements)

References 108 publications

(128 reference statements)

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“…Це відповідає результатам попередніх досліджень: у хворих на ХСН за умов коморбідності з ФП встановлено збільшення ризику настання ККТ, серцево-судинної смерті та декомпенсації захворювання, що зумовило необхідність повторної госпіталізації [8,16,17].…”

Section: результатиunclassified

“…ФВ ЛШ із фібриляцією передсердь (ФП), особливо за наявності супутньої надлишкової маси тіла (НМТ) та абдомінального ожиріння [6,7]. ФП пов'язують із 4-разовим збільшенням ризику ХСН, що розвивається у третини таких пацієнтів [8]. За даними довгострокового реєстру Європейського товариства кардіологів, майже 20 % пацієнтів із ХСН зб.…”

unclassified

“…Отже, ХСН зб. ФВ ЛШ, як правило, супроводжується супутньою патологією, ця коморбідність взаємно обтяжена, призводить до прогресування захворювання, створює передумови для збільшення ризику несприятливих наслідків і смертності, зокрема протягом короткочасного та тривалого періоду [5,6,8].…”

unclassified

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Clinical course and outcomes of chronic heart failure with preserved left ventricular ejection fraction in concomitant overweight and obesity with comorbid atrial fibrillation

Бідзіля¹,

Каджарян²,

Капшитарь³

2021

ZMJ

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Aim. To study the features of the clinical course and outcomes of chronic heart failure with preserved left ventricular ejection fraction (CHFprEF) in overweight and obese patients with concomitant atrial fibrillation (AF). Materials and methods. 248 overweight and obese patients with CHFprEF, aged 65.0 ± 11.0 years, 146 females (58.9 %) and 102 males (41.1 %) were examined. The first group consisted of 181 patients without concomitant AF, mean age 64.0 ± 11.0 years, 110 females (60.8 %) and 71 males (39.2 %). The second group included 67 patients with AF, mean age 67.9 ± 11.3 years, 36 females (53.7 %) and 31 males (46.3 %). Results. Comorbid AF was associated with a more severe course of CHFprEF by the rating scale of clinical state (0.9 points), Borg scale (1.7 points), a significant predominance of orthopnea (by 16.6 %), night cough (by 27.9 %), cardiac asthma (by 27.2 %), low exercise tolerance (by 14.3 %), weakness (by 23.7 %), palpitations (by 72.9 %), edema of the feet (by 40.6 %), rapid weight gain (by 32.6 %), jugular venous distention (by 21.4 %), pathological third heart sound (by 16.7 %), percussion extension of the cardiac borders (by 41.4 %) and dullness over the lungs (28.9 %), moist rales (24.3 %), second sound with a loud pulmonic component (by 33.9 %), tachypnea (by 25.9 %), hepatomegaly (by 32.0 %) and ascites (by 13.6 %), increased risk of cumulative endpoint (by 2.7 times), five-year mortality (by 3.4 times) and rehospitalization (by 3 times) (P ˂ 0.001). Conclusions. AF as the comorbidity in overweight and obese patients is associated with more severe clinical course of CHFprEF and worse five-year outcomes.

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Section: результатиunclassified

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Clinical course and outcomes of chronic heart failure with preserved left ventricular ejection fraction in concomitant overweight and obesity with comorbid atrial fibrillation

Бідзіля¹,

Каджарян²,

Капшитарь³

2021

ZMJ

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“…Sudden cardiac death (SCD) represents a principal cause of mortality in post‐myocardial infarction (post‐MI) patients with mildly reduced or preserved left ventricular ejection fraction (LVEF) (Pannone et al., 2021 ; Vaduganathan et al., 2017 ). Several electrocardiographic non‐invasive risk factors (NIRFs) for SCD risk stratification in post‐MI patients with mildly reduced or preserved LVEF have been examined but their exact and relative value remains unclear.…”

Section: Introductionmentioning

confidence: 99%

Association of non‐invasive electrocardiographic risk factors with left ventricular systolic function in post‐myocardial infarction patients with mildly reduced or preserved ejection fraction: Insights from the PRESERVE‐EF study

Tsimos

Korantzopoulos

Αρσένος

et al. 2022

Noninvasive Electrocardiol

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Background: Electrocardiographic non-invasive risk factors (NIRFs) have an important role in the arrhythmic risk stratification of post-myocardial infarction (post-MI) patients with preserved or mildly reduced left ventricular ejection fraction (LVEF). However, their specific relation to left ventricular systolic function remains unclear. We aimed to evaluate the association between NIRFs and LVEF in the patients included in the PRESERVE-EF trial. Methods: We studied 575 post-MI ischemia-free patients with LVEF≥40% (mean age: 57.0 ± 10.4 years, 86.2% men). The following NIRFs were evaluated: premature ventricular complexes, non-sustained ventricular tachycardia (NSVT), late potentials (LPs), prolonged QTc, increased T-wave alternans, reduced heart rate variability, and abnormal deceleration capacity with abnormal turbulence.Results: There was a statistically significant relationship between LPs (Chisquared = 4.975; p < .05), nsVT (Chi-squared = 5.749, p < .05), PVCs (r= −.136; p < .01), and the LVEF. The multivariate linear regression analysis showed that LPs (p = .001) and NSVT (p < .001) were significant predictors of the LVEF. The results of the multivariate logistic regression analysis indicated that LPs (OR: 1.76; 95% CI: 1.02-3.05; p = .004) and NSVT (OR: 2.44; 95% CI: 1.18-5.04; p = .001) were independent predictors of the mildly reduced LVEF: 40%-49% versus the preserved LVEF: ≥50%.

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“…Sudden coronary death (SCD) is the most common type of sudden death in adults, particularly in middle-aged and elderly individuals ( 1 ). SCD primarily occurs when coronary atherosclerosis results in acute myocardial ischemia and there is a sudden interruption to coronary blood flow ( 2-4 ). SCD frequently occurs after an inducement, such as drinking alcohol, fatigue, smoking or exercise, and may be fatal within a small number of hours, whereby certain individuals pass away during their sleep ( 5 ).…”

Section: Introductionmentioning

confidence: 99%

Risk of sudden coronary death based on genetic background in Chinese Han population

et al. 2021

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Associations between gene variations and sudden cardiac arrest or coronary artery disease have been reported by genome-wide association studies. However, the implication of the genetic status in cases of sudden coronary death (SCD) from the Chinese Han population has remained to be investigated. The present study established a mini-sequencing system to examine putative death-causing single nucleotide polymorphisms (SNPs) using multiplex PCR, single base extension reaction and capillary electrophoresis techniques. A total of 198 samples from the Chinese Han population (age range, 34-71 years; mean age, 53.86 years) were examined using this method. Samples were classified into three groups: Coronary heart disease (CHD, n=70), SCD (n=53) and control (n=75) group. Significant associations were identified for 10, 4 and 6 SNPs in CHD, SCD and sudden death from CHD, respectively, using the χ 2 test. The SNPs obtained by binary logistic regression may be used to assess and predict the risk of disease. The predictive accuracy of the SNPs in each prediction model and their area under the receiver operating characteristic curve (AUC) values were determined. The AUC of the four SNPs (rs12429889, rs10829156, rs16942421 and rs12155623) to predict CHD was 0.928, the AUC of the six SNPs (rs2389202, rs2982694, rs10183640, rs597503, rs16942421 and rs12155623) to predict SCD was 0.922 and the AUC of the four SNPs (rs16866933, rs4621553, rs10829156 and rs12155623) to predict sudden death from CHD was 0.912. The multifactor dimensionality reduction values were as follows: 0.8690 (prediction model of CHD), 0.7601 (prediction model of SCD) and 0.7628 (prediction model of sudden death from CHD). Taken together, the results of the present study suggested that these SNPs have considerable potential for application in genetic tests to predict CHD or SCD. However, further studies are required to investigate the putative functions of these SNPs.

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Sudden Cardiac Death in Patients with Heart Disease and Preserved Systolic Function: Current Options for Risk Stratification

Cited by 12 publications

References 108 publications

Clinical course and outcomes of chronic heart failure with preserved left ventricular ejection fraction in concomitant overweight and obesity with comorbid atrial fibrillation

Clinical course and outcomes of chronic heart failure with preserved left ventricular ejection fraction in concomitant overweight and obesity with comorbid atrial fibrillation

Association of non‐invasive electrocardiographic risk factors with left ventricular systolic function in post‐myocardial infarction patients with mildly reduced or preserved ejection fraction: Insights from the PRESERVE‐EF study

Risk of sudden coronary death based on genetic background in Chinese Han population

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