The Future of Ageing: not more of the same

Sikora, Ewa; Rattan, Suresh

doi:10.1007/s10522-017-9720-x

Cited by 3 publications

(1 citation statement)

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“…In order to overcome negative effects of cellular senescence on human health [ 17 ], it is essential to identify aging‐related pathways and mediators to elaborate senescence‐associated mechanisms, including maintenance of mitochondrial functions, interorganelle communication, proteostasis, and metabolic signaling in selected cellular and organismal aging models. The identification of pathways and cellular targets along with lead compounds may pave the way for the development of treatment strategies to counteract age‐associated cellular dysfunction and, ultimately, pathophysiological processes, to promote healthy aging [ 18 ].…”

Section: Introductionmentioning

confidence: 99%

Targeting cellular senescence based on interorganelle communication, multilevel proteostasis, and metabolic control

et al. 2020

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to counteract senescence yet. Therefore, we explore possibilities to target these mechanisms as new opportunities to selectively eliminate and/or disable senescent cells with the aim of tissue rejuvenation. We assume that this research will provide new compounds from the chemical space which act as mimetics of caloric restriction, modulators of calcium signaling and mitochondrial physiology, or as proteostasis optimizers, bearing the potential to counteract cellular senescence, thereby allowing healthy aging.

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Section: Introductionmentioning

confidence: 99%

Targeting cellular senescence based on interorganelle communication, multilevel proteostasis, and metabolic control

et al. 2020

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Challenges in the Healthcare Systems and Formative Needs of Family Doctors

Poltronieri

2018

Challenges

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Envelhecimento populacional, segmento mais idoso e as atividades básicas da vida diária como indicador de velhice autônoma e ativa

Oliveira

Rossi

2019

Geosul

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O envelhecimento da população é marcado por diferenças que se acentuam na medida em que as idades avançam. No Brasil, o termo terceira idade ficou velho, no sentido de que à velhice tornou-se um período maior, envolvendo idosos com as mais diversas características. Assim, surge o termo quarta idade ou segmento mais idoso, que marca o período da velhice que engloba os aspectos negativos dessa fase da vida como a dependência. A qualidade de vida na velhice está muito ligada com à manutenção da capacidade de realizar as atividades básicas da vida diária e a perda pode impactar de modo negativo na vida do idoso, principalmente o idoso mais velho.

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The Future of Ageing: not more of the same

Cited by 3 publications

References 20 publications

Targeting cellular senescence based on interorganelle communication, multilevel proteostasis, and metabolic control

Targeting cellular senescence based on interorganelle communication, multilevel proteostasis, and metabolic control

Challenges in the Healthcare Systems and Formative Needs of Family Doctors

Envelhecimento populacional, segmento mais idoso e as atividades básicas da vida diária como indicador de velhice autônoma e ativa

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