The functional sequelae of sacrococcygeal teratoma

Malone, P.S.; Spitz, Lewis; Kiely, Edward M.; Brereton, R.J.; Duffy, P.G.; Ransley, P. G.

doi:10.1016/0022-3468(90)90362-d

Cited by 80 publications

(52 citation statements)

References 7 publications

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“…Four of our patients had malignant histology on presentation; two were lost to follow-up after initial excision and chemotherapy, while two were well at 12 and 24 months after surgical excision and chemotherapy. Even though our patients with malignant disease were few, it would appear that they do well after chemotherapy and excision as noted by Wakhlu et al [8] A number of reports have attempted to assess longterm outcome after treatment of SCT; [8,10,11,[15][16][17] which include continence, quality of life, and sexual function. In one UK study on the long-term followup of children treated for SCT, [18] a third had some functional problems, and Malone et al, found as many as 41% of children treated for SCT with some long-term functional sequelae.…”

Section: Discussionmentioning

confidence: 72%

“…In one UK study on the long-term followup of children treated for SCT, [18] a third had some functional problems, and Malone et al, found as many as 41% of children treated for SCT with some long-term functional sequelae. [16] In this present series, only 21 (60%) had some long-term follow-up information; 5 (23.8%) of them had some degree of functional impairments [ Table 1]. …”

Section: Discussionmentioning

confidence: 78%

“…Ascraft and Holder in 1965 reported two children with presacral tumor and anal stenosis and later 17 others with presacral tumor and sacral defects with most of them having anal stenosis in six kindreds. [15,16] This led them to suggest an autosomal dominant nature of the tumor. Currarino later described three more cases and suggested that the etiology may be related to adhesions between the ectoderm and neural endoderm causing a split notochord.…”

Section: Discussionmentioning

confidence: 99%

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Sacrococcygeal teratoma: Clinical characteristics and long-term outcome in Nigerian children

et al. 2009

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Background/Purpose: The excision of sacrococcygeal teratoma (SCT) may be associated with signifi cant long-term morbidity for the child. We reviewed our experience with SCT in a tertiary health care facility in a developing country with particular interest on the long-term sequelae. Methods: Between January 1990 and May 2008 inclusive, 38 consecutive children with the diagnosis of SCT were identifi ed from the operation register and the Cancer Registry of the Jos University Teaching Hospital. Their clinical presentation, investigation, operative fi ndings, histology report, and outcome were recorded and analyzed. The long-term follow-up of some of the patients were also recorded and analyzed. Results: There were 31 females and 7 males. Twenty-three patients presented during the neonatal period with a median age at presentation of 7 days (range 1-18 days) and a median weight at presentation of 2.8 kg (range 2.0-3.6kg), 10 presented between 1 month and 12 months, while 5 were older than 1 year at presentation. Most of the patients had signifi cantly external tumors. Excision of the tumor was mainly by the sacral route, four had abdominal-sacral excision. Histology was mainly benign; four were malignant at presentation. Four children with malignant disease had chemotherapy in addition to excision of the tumor. Eight had immediate post-operative wound-related complications while three children died, two of the deaths were related to anesthesia, while one died of colostomy complications. Twenty-one (60%) were followed up for a median duration of 6 years (range 1 month-8 years). Two (9.5%) had recurrent disease after primary excision; fi ve (23.8%) had some degree of functional impairment at the follow-up. Conclusion: While SCT is usually benign, recurrence, malignant transformations in patients who present late and longterm functional sequelae are problems that must be tackled by the care givers. A multi-center study may be necessary to characterize this disease in developing countries and assess the long-term functional sequelae in survivors.

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Section: Discussionmentioning

confidence: 72%

Section: Discussionmentioning

confidence: 78%

Section: Discussionmentioning

confidence: 99%

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Sacrococcygeal teratoma: Clinical characteristics and long-term outcome in Nigerian children

et al. 2009

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“…Other less common modes of presenta ons are bowel obstruc on, urinary obstruc on, and ulcera on over the swelling. Ascra and Holder in 1965 reported the associa on of sacral mass with sacral defect and anal stenosis 14,15 . Associa on of SCT along with anorectal malforma on and sacral agenesis is called as Currarino triad 16 .…”

Section: Resultsmentioning

confidence: 99%

Sacrococcygeal Teratoma: Experience with 36 Patients in a Teritiary Care Hospital

Kundal

Jadhav

Gupta

et al. 2015

J. Nepal Paedtr. Soc.

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Introduction: Sacrococcygeal teratomas (SCT) are the most common solid tumours in the neonatal period, originate from embryonic totipotent cells. Most of them are benign however some that present later in life and have major intra-pelvic component have greater malignant potential. Complete surgical excision provides an excellent prognosis. The aim of this study was to describe the clinical profile, age of presentation, sex distribution, diagnostic evaluation and management of children with a histological confirmed diagnosis of sacrococcygeal teratoma.Material and Methods: Patients with histological diagnosis of sacrococcygeal teratoma during a period from January 2011 to December 2012 were included in this retrospective study. Data collected included age of presentation, sex distribution, symptoms, associated anomalies, diagnostic evaluation, operative approach technique employed, tumour histology, operative complications and outcome.Results: Thirty six patients with diagnosis of sacrococcygeal teratoma were included in the study. Of these children, 58.33% were females and 41.66% were males. The median age at presentation was four days. 69.44% of patients presented during the neonatal period. 77.77% of patients presented with sacrococcygeal mass followed by lower abdominal mass in 11.11%. The tumour was resected by sacral approach in 27 patients and abdomino sacral approach in nine patients. Tumour was resectable in 34 patients and two had incomplete resection. Follow up duration varied from six months to 24 months.Conclusion: Sacrococcygeal teratomas represent a group of benign and malignant lesions of children. Neonates present with benign disease and aggressive lesions are seen as age progresses. Overall survival of SCT is high.J Nepal Paediatr Soc 2015;35(1):89-93

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“…Compression or infiltration of the sacral nerves by the tumour and surgical trauma to hypogastric nerves during tumour resection cause damage to the innervation of the lower urinary tract in sacrococcygeal teratoma 11,14,[27][28][29][30][31] . In addition, neuropathic bladder, vesicoureteric reflux, incontinence, recurrent urinary tract infections and impotence are possible complications after resection of sacrococcygeal teratomas 10,29,32,33 . The prenatal diagnosis of the sacrococcygeal teratomas can be easily made with conventional two-dimensional ultrasound scan 12 .…”

Section: Discussionmentioning

confidence: 99%

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The functional sequelae of sacrococcygeal teratoma

Cited by 80 publications

References 7 publications

Sacrococcygeal teratoma: Clinical characteristics and long-term outcome in Nigerian children

Sacrococcygeal teratoma: Clinical characteristics and long-term outcome in Nigerian children

Sacrococcygeal Teratoma: Experience with 36 Patients in a Teritiary Care Hospital

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