The Functional Promoter Polymorphism of the Coagulation Factor XII Gene is not Associated With Peripheral Arterial Disease

Yazdani‐Biuki, Babak; Krippl, Peter; Brickmann, Kerstin; Fuerst, Florentine; Langsenlehner, Uwe; Paulweber, Bernhard; Pilger, Ernst; Wascher, Thomas C.; Brezinschek, Hans‐Peter; Renner, Wilfried

doi:10.1177/0003319709337305

Cited by 3 publications

(2 citation statements)

References 26 publications

(20 reference statements)

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“…118 Furthermore, several studies did not observe an effect of the polymorphism on arterial thrombosis. [119][120][121][122][123] The association of the −4C/T polymorphism and arterial thrombosis is influenced by cholesterol levels. Pravastatin treatment reduced the risk of CAD in men with a CC or CT genotype, but not in men with a TT genotype.…”

Section: Factor XIImentioning

confidence: 99%

Novel Insights into Genetics of Arterial Thrombosis

Konings¹,

Govers‐Riemslag²,

Cate

2010

Clinical Cardiogenetics

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Section: Factor XIImentioning

confidence: 99%

Novel Insights into Genetics of Arterial Thrombosis

Konings¹,

Govers‐Riemslag²,

Cate

2010

Clinical Cardiogenetics

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“…The TT-genotype was associated with an increased risk of CAD in men with high cholesterol [115] and with both CAD and ischemic stroke in the Spanish population [116,117]; however, in patients with pre-existing CAD the TTgenotype had a protective effect on the development of ACS [118]. Furthermore, several studies did not observe an effect of the polymorphism on arterial thrombosis [119][120][121][122][123].…”

Section: Factor XIImentioning

confidence: 99%

The role of coagulation factor XII in fibrin clot formation and fibrinolysis

Konings

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Impact of Intrinsic Coagulation Pathway Factors Activity and Hemostatic Markers of Endothelial Dysfunction on Thrombotic Complications in Patients with Atherosclerotic Peripheral Arterial Disease

Каlinin¹,

Suchkov²,

Mzhavanadze³

et al. 2017

Novosti Khirurgii

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ФГБОУ ВО «Рязанский государственный медицинский университет имени академика И.П. Павлова», Российская ФедерацияСовременная сосудистая хирургия располагает различными вариантами проведения открытых и чрескожных эндоваскулярных вмешательств, направленных на лечение пациентов с заболеваниями периферических артерий. Одними из наиболее распространенных осложнений оперативных вмеша-тельств являются тромбозы. По данным разных авторов, послеоперационный тромбоз развивается в 60-90% случаев, особенно при проведении дистальных реконструкций. Основную роль в развитии тромботических осложнений играет свертывающая система крови. Влияние внешнего пути каскада коагуляции на процесс тромбообразования у пациентов с периферическим атеросклерозом широко ос-вещено и исследовано, что способствовало внедрению разнообразных антитромботических препаратов. Внутренний путь всегда рассматривался как менее значимый. В настоящее время внутренний путь вы-зывает значительный интерес с точки зрения развития тромбозов и патогенеза процессов воспаления. При высоком уровне ХI, IХ факторов повышается риск тромботических осложнений, разработаны их новейшие ингибиторы. XII и VIII факторы изучены недостаточно. Не менее важную роль в развитии тромбоза играют гемостатические маркеры дисфункции эндотелия, такие как фактор фон Виллебранда (ФВ), ингибитор активатора плазминогена-1 (ПАИ-1), протеин С (ПрС) и его эндотелиальный рецеп-тор. Изменения гемостатических маркеров дисфункции эндотелия в послеоперационном периоде -повышение ФВ и ПАИ-1 и дефицит ПрС -играют значительную роль в развитии тромботических ос-ложнений и могут определять проходимость сосудистых реконструкций. Дальнейшее изучение в этом направлении позволит определить предикторы тромботических осложнений и разработать алгоритмы оптимальной антитромботической терапии. Ключевые слова: атеросклероз, внутренний каскад коагуляции, гемостатические маркеры дисфункции эндотелия, тромботические осложнения, антитромботическая терапияModern vascular surgery has various options for performing open and percutaneous endovascular interventions aimed to treat patients with peripheral arterial disease. One of the most common complications of surgical interventions is thrombosis. According to different authors' data, postoperative thrombosis develops in 60-90% of cases, especially when performing distal reconstructions. The coagulating blood system plays the main role in the development of thrombotic complications. The effect of the extrinsic pathway of the coagulation cascade on the process of thrombus formation in patients with peripheral atherosclerosis is widely covered and investigated, which facilitated the introduction of a variety of antithrombotic drugs. The intrinsic pathway has always been considered less important. Nowadays, the internal pathway is of considerable interest from the point of view of the development of thromboses and the pathogenesis of inflammatory processes. With a high level of XI, IX factors, the risk of thrombotic complications increases, their newest inhibitors have been devel...

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The Functional Promoter Polymorphism of the Coagulation Factor XII Gene is not Associated With Peripheral Arterial Disease

Cited by 3 publications

References 26 publications

Novel Insights into Genetics of Arterial Thrombosis

Novel Insights into Genetics of Arterial Thrombosis

The role of coagulation factor XII in fibrin clot formation and fibrinolysis

Impact of Intrinsic Coagulation Pathway Factors Activity and Hemostatic Markers of Endothelial Dysfunction on Thrombotic Complications in Patients with Atherosclerotic Peripheral Arterial Disease

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