The functional insufficiency of human CD4<sup>+</sup>CD25<sup>high</sup> T‐regulatory cells in allergic asthma is subjected to TNF‐α modulation

Lin, Yuh Jyh; Shieh, Chi‐Chang; Wang, Jiu-Yao

doi:10.1111/j.1398-9995.2007.01526.x

Cited by 104 publications

(102 citation statements)

References 34 publications

(44 reference statements)

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“…T reg function has also been shown to be defective in collagen-induced arthritis (CIA) [119] and there is also evidence from other diseases that TNF-a compromises the activity and/or numbers of T reg cells. For example, deficient suppressor cell activity was observed in human CD4 + CD25 + T reg in allergic asthma and this deficiency could be corrected by TNF-a blockade [132]. Similar conclusions were reached in EAE [133], MS [134] and type 1 diabetes [135].…”

Section: Cd25mentioning

confidence: 57%

Effector T cells in rheumatoid arthritis: Lessons from animal models

Alzabin

Williams

2011

FEBS Letters

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The development of an immune response to self antigens drives naive T cells to differentiate into subsets of CD8+ and CD4+ effector cells including TH1, TH2, cells and the more recently described TH17, and regulatory T cells (Treg). Rheumatoid arthritis is an autoimmune disease that engages an uncontrolled influx of inflammatory cells to the joints, eventually leading to joint damage. The role that effector T cells play in the local or systemic maintenance of, or protection against, inflammation and subsequent joint damage is now becoming better understood through the use of animal models. In this review, we will explore the different animal models of RA, and their contribution to elucidating the role that effector T cells play in the regulation, induction, and maintenance of inflammatory joint disease. This understanding will aid in the design of more effective therapeutic strategies for rheumatoid arthritis and other autoimmune disorders.

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Section: Cd25mentioning

confidence: 57%

Effector T cells in rheumatoid arthritis: Lessons from animal models

Alzabin

Williams

2011

FEBS Letters

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“…that express the highest density of CD25 in human (Lin et al 2008). The quality or quantity of CD4 + CD25 high Tregs from peripheral blood of patients with active SLE was significantly decreased as compared with normal donors and patients with inactive SLE (Valencia et al 2007;Bonelli et al 2009;Cai et al 2015b).…”

Section: Discussionmentioning

confidence: 99%

Interleukin-35 as a New Biomarker of Renal Involvement in Lupus Nephritis Patients

Liu

2018

Tohoku J. Exp. Med.

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Systemic lupus erythematosus (SLE) is an autoimmune connective tissue disease with a wide range of clinical presentations. Lupus nephritis (LN) is the most serious manifestation of SLE. , a member of the interleukin-12 family, has been identified as a novel anti-inflammatory cytokine. In the past ten years, the role of IL-35 in inflammatory and autoimmune diseases has been studied extensively. Serum IL-35 levels, however, have not been studied in LN patients. The aim of the study was to determine serum IL-35 levels in SLE patients with and without nephritis, and their clinical values. The study was carried out on 120 SLE patients, which comprised 80 LN patients and 40 SLE patients without nephritis. SLE disease activity was measured according to Systemic Lupus Erythematosus Dis ease Activity Index-2 k (SLEDAI-2 k). Statistical evaluation was based on Mann-Whitney U-test, t-test, chi-square test, Spearman rank correlation test and Pearson's correlation test. The result showed that active SLE patients (n = 65) have lower serum IL-35 levels, compared to inactive SLE patients (n = 55, P < 0.001). Furthermore, serum IL-35 levels were significantly lower in LN patients (n = 80) than SLE patients without nephritis (n = 40, P = 0.013). Serum IL-35 levels had significant correlations with SLEDAI-2k (r = -0.626, P < 0.001) in SLE patients and estimated glomerular filtration rate (eGFR) (r = 0.348, P = 0.002) in LN patients. These results indicate that IL-35 is a potential biomarker of renal involvement in LN patients.

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“…It has been shown that oral administration of LAB induces CD4 + CD25 + Foxp3 + regulatory T cells, which suppress allergic disorders such as asthma or food allergy (39,40). In Peyer's patches and spleen, these cells cause suppression of IgE production (41).…”

Section: Discussionmentioning

confidence: 99%

A sulfated polysaccharide, fucoidan, enhances the immunomodulatory effects of lactic acid bacteria

Kawashima

Murakami²,

Nishimura³

et al. 2011

Int J Mol Med

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Abstract. Fucoidan, a sulfated polysaccharide contained in brown algae, has a variety of immunomodulatory effects, including antitumor and antiviral effects. On the other hand, lactic acid bacteria (LAB) also have immunomodulatory effects such as anti-allergic effects. In this study, we demonstrated that fucoidan enhances the probiotic effects of LAB on immune functions. By using Peyer's patch cells and spleen cells in vitro, fucoidan amplified interferon (IFN)-γ production in response to a strain of LAB, Tetragenococcus halophilus KK221, and this activity was abolished by desulfation of fucoidan. Moreover, this IFN-γ response was abolished by interleukin (IL)-12 neutralization. These results indicate that fucoidan enhanced IL-12 production in response to KK221, resulting in promoting IFN-γ production. In an in vivo study, Th1/Th2 immunobalance was most improved by oral administration of both fucoidan and KK221 to ovalbumin-immunized mice. These findings suggest that fucoidan can enhance a variety of beneficial effects of LAB on immune functions.

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The functional insufficiency of human CD4⁺CD25^high T‐regulatory cells in allergic asthma is subjected to TNF‐α modulation

Abstract: The functional insufficiency of nTreg cells in patients with allergic asthma may be related to the enhanced production of TNF-alpha and its effect on the Foxp3 expression. These results may explain, in part, the effectiveness of anti-TNF-alpha therapy in the treatment of allergic asthma.

Cited by 104 publications

References 34 publications

Effector T cells in rheumatoid arthritis: Lessons from animal models

Effector T cells in rheumatoid arthritis: Lessons from animal models

Interleukin-35 as a New Biomarker of Renal Involvement in Lupus Nephritis Patients

A sulfated polysaccharide, fucoidan, enhances the immunomodulatory effects of lactic acid bacteria

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The functional insufficiency of human CD4+CD25high T‐regulatory cells in allergic asthma is subjected to TNF‐α modulation

Abstract: The functional insufficiency of nTreg cells in patients with allergic asthma may be related to the enhanced production of TNF-alpha and its effect on the Foxp3 expression. These results may explain, in part, the effectiveness of anti-TNF-alpha therapy in the treatment of allergic asthma.

Cited by 104 publications

References 34 publications

Effector T cells in rheumatoid arthritis: Lessons from animal models

Effector T cells in rheumatoid arthritis: Lessons from animal models

Interleukin-35 as a New Biomarker of Renal Involvement in Lupus Nephritis Patients

A sulfated polysaccharide, fucoidan, enhances the immunomodulatory effects of lactic acid bacteria

Contact Info

Product

Resources

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The functional insufficiency of human CD4⁺CD25^high T‐regulatory cells in allergic asthma is subjected to TNF‐α modulation