A sulfated polysaccharide, fucoidan, enhances the immunomodulatory effects of lactic acid bacteria

Kawashima, Tadaomi; Murakami, Katsura; Nishimura, Ikuya; Nakano, Takahisa; Obata, Akio

doi:10.3892/ijmm.2011.854

Cited by 21 publications

(18 citation statements)

References 39 publications

(62 reference statements)

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“…Recently, the genetic diversity of Tetragenococcus in some salt‐ and sugar‐rich environments has been determined by PCR‐based molecular approaches, yet still only a limited number of species have been isolated (Juste and others ; Fukui and others ; Nam and others ; Chuon and others ). It was recently reported that T. halophilus has an immunomodulatory effect that attenuates allergic symptoms by promoting Th1/Th2 immune balance (Masuda and others ; Kawashima and others ). However, further studies will be needed in order to fully understand the characteristics of this genus.…”

Section: Resultsmentioning

confidence: 99%

Bacterial Communities of Traditional Salted and Fermented Seafoods from Jeju Island of Korea Using 16S rRNA Gene Clone Library Analysis

Kim

Park

2014

Journal of Food Science

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Jeotgal, which is widely consumed as a nutritional supplement in Korea, is traditional type of preserved seafood that is prepared by salting and fermenting. Here, we report on the bacterial community structure and diversity of jeotgal obtained from the Korean island of Jeju, which has a subtropical climate. Two samples of Jeotgal were collected from Jeju, made from either damselfish (Chromis notata; jari-dom-jeot, J1 and J2) or silver-stripe round herring (Spratelloides gracilis; ggot-myulchi-jeot, K1 and K2). The physical characteristics (pH and salinity) were assessed and the bacterial communities characterized using 16S rRNA gene-clone library analysis and cultural isolation. No difference was found in the community composition between the J and K fermented seafoods. Both fermented seafoods had relatively high salinity (26% to 33%) and high pH values (pH 6.08 to 6.72). Based on the 16S rRNA gene sequences, the halophilic lactic-acid bacteria Tetragenococcus halophilus and T. muriaticus were observed to be dominant in the J and K fermented seafoods, accompanied by halophilic bacteria including Halanaerobium spp., Halomonas spp., and Chromohalobacter spp. When compared with 7 other types of fermented seafood from a previous study, the communities of the J and K fermented seafoods were separated by the most influential group, the genus Tetragenococcus. The results suggest that these 2 types of traditional salted fermented seafood from Jeju have distinct communities dominated by Tetragenococcus spp., which are derived from the raw ingredients and are dependent on the physical conditions. This may explain how the seafoods that are made in Jeju may differ from other jeotgals.

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Section: Resultsmentioning

confidence: 99%

Bacterial Communities of Traditional Salted and Fermented Seafoods from Jeju Island of Korea Using 16S rRNA Gene Clone Library Analysis

Kim

Park

2014

Journal of Food Science

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“…Alginic acid, an anionic polysaccharide in Sargassum wightii , exhibited anti-inflammatory effects in a rat study of adjuvant-induced arthritis [80]. Fucoidan is known to enhance the probiotic effects of Lactic acid bacteria (LAB) by immunomodulation of an anti-allergic response [81]. Fucans from Lobophora variegata [82], Sargassum vulgare [83], and Spatoglossum schroederi [84] also have both anti-inflammatory and antinociceptive effects.…”

Section: Anti-inflammatory and Antinociceptive Properties Of Marine Amentioning

confidence: 99%

Marine algal natural products with anti-oxidative, anti-inflammatory, and anti-cancer properties

et al. 2013

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For their various bioactivities, biomaterials derived from marine algae are important ingredients in many products, such as cosmetics and drugs for treating cancer and other diseases. This mini-review comprehensively compares the bioactivities and biological functions of biomaterials from red, green, brown, and blue-green algae. The anti-oxidative effects and bioactivities of several different crude extracts of algae have been evaluated both in vitro and in vivo. Natural products derived from marine algae protect cells by modulating the effects of oxidative stress. Because oxidative stress plays important roles in inflammatory reactions and in carcinogenesis, marine algal natural products have potential for use in anti-cancer and anti-inflammatory drugs.

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“…These effects promote the activation of natural killer (NK) cells, resulting in enhancement of pro-inflammatory cytokine production and anti-viral action [18]. Moreover, fucoidan can potently induce production of interferon-γ (IFN-γ) by CD4 and CD8 T cells and induce T cell cytotoxicity against antigen-expressing human cancer cells or bacteria [19], [20]. In addition, fucoidan has been shown to induce activation and maturation of human and mouse DCs in vitro [21]–[23].…”

Section: Introductionmentioning

confidence: 99%

Fucoidan Can Function as an Adjuvant In Vivo to Enhance Dendritic Cell Maturation and Function and Promote Antigen-Specific T Cell Immune Responses

et al. 2014

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Fucoidan, a sulfated polysaccharide purified from brown algae, has a variety of immune-modulation effects, including promoting antigen uptake and enhancing anti-viral and anti-tumor effects. However, the effect of fucoidan in vivo, especially its adjuvant effect on in vivo anti-tumor immune responses, was not fully investigated. In this study, we investigated the effect of fucoidan on the function of spleen dendritic cells (DCs) and its adjuvant effect in vivo. Systemic administration of fucoidan induced up-regulation of CD40, CD80 and CD86 expression and production of IL-6, IL-12 and TNF-α in spleen cDCs. Fucoidan also promoted the generation of IFN-γ-producing Th1 and Tc1 cells in an IL-12-dependent manner. When used as an adjuvant in vivo with ovalbumin (OVA) antigen, fucoidan promoted OVA-specific antibody production and primed IFN-γ production in OVA-specific T cells. Moreover, fucoidan enhanced OVA-induced up-regulation of MHC class I and II on spleen cDCs and strongly prompted the proliferation of OVA-specific CD4 and CD8 T cells. Finally, OVA immunization with fucoidan as adjuvant protected mice from the challenge with B16-OVA tumor cells. Taken together, these results suggest that fucoidan can function as an adjuvant to induce Th1 immune response and CTL activation, which may be useful in tumor vaccine development.

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A sulfated polysaccharide, fucoidan, enhances the immunomodulatory effects of lactic acid bacteria

Cited by 21 publications

References 39 publications

Bacterial Communities of Traditional Salted and Fermented Seafoods from Jeju Island of Korea Using 16S rRNA Gene Clone Library Analysis

Bacterial Communities of Traditional Salted and Fermented Seafoods from Jeju Island of Korea Using 16S rRNA Gene Clone Library Analysis

Marine algal natural products with anti-oxidative, anti-inflammatory, and anti-cancer properties

Fucoidan Can Function as an Adjuvant In Vivo to Enhance Dendritic Cell Maturation and Function and Promote Antigen-Specific T Cell Immune Responses

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