The Functional Gastrointestinal Disorders and the Rome III Process

Drossman, Douglas A.

doi:10.1053/j.gastro.2006.03.008

Cited by 2,081 publications

(1,901 citation statements)

References 97 publications

Supporting

Mentioning

1,767

Contrasting

Unclassified

117

Order By: Relevance

“…The prevalence of IBS is significantly higher in women than in men 35. There was also a high rate of symptomatic young and middle‐aged (18‐65 years) women in our study population (83.3%) who were assigned to the IBS category according to the Rome III criteria 25, 26. Evidence suggests associations between a histamine‐rich diet and IBS 2.…”

Section: Discussionmentioning

confidence: 58%

See 1 more Smart Citation

Circadian profiling reveals higher histamine plasma levels and lower diamine oxidase serum activities in 24% of patients with suspected histamine intolerance compared to food allergy and controls

Pinzer

Tietz

Waldmann

et al. 2017

Allergy

View full text Add to dashboard Cite

BackgroundHistamine intolerance is thought to trigger manifold clinical symptoms after ingesting histamine‐rich food due to reduced activity of diamine oxidase (DAO). No study has hitherto systematically assessed daily fluctuations of histamine levels and DAO activities in symptomatic patients. The aim of the study was to investigate the presence of histamine intolerance, to therefore establish day profiles of histamine levels and DAO activities, and to compare the results between patients with suspected histamine intolerance, food allergy and healthy controls.MethodsWe determined day profiles of histamine plasma levels and DAO serum activities in 33 patients with suspected histamine intolerance, in 21 patients with proven food allergy and in 10 healthy control patients. Clinical symptoms, food intolerances and further clinical and laboratory chemical parameters were evaluated.ResultsTwenty‐four percent (8 of 33) suspected histamine‐intolerant patients showed elevated histamine levels during the day. That might be caused by constantly and significantly reduced DAO activities in these patients compared to food‐allergic and control patients. The remaining 25 patients presented normal histamine levels and DAO activities, but an increased prevalence of multiple food intolerances compared to the other subgroup of suspected histamine‐intolerants. There was no correlation between subjective complaints and serological histamine parameters in patients with suspected histamine intolerance.ConclusionsWe determined by daily profiling that decreased DAO activities correlated with elevated histamine levels in a subgroup of suspected histamine‐intolerants. This finding discriminates these patients from food intolerant individuals with similar clinical symptoms and strongly suggests the presence of histamine intolerance.

show abstract

Section: Discussionmentioning

confidence: 58%

“…The survey at the examination day assessed clinical symptoms, underlying diseases and both nicotine and alcohol consumption. Furthermore, IBS symptoms were recorded using questionnaires based on the Rome III criteria 25, 26…”

Section: Methodsmentioning

confidence: 99%

Circadian profiling reveals higher histamine plasma levels and lower diamine oxidase serum activities in 24% of patients with suspected histamine intolerance compared to food allergy and controls

Pinzer

Tietz

Waldmann

et al. 2017

Allergy

View full text Add to dashboard Cite

show abstract

“…Although the emphasis in patients with IBS is to make a positive diagnosis nevertheless it is important to exclude diseases that may present with IBS type symptoms ( 3,4 ).…”

Section: Introductionmentioning

confidence: 99%

Editorial: Non-Celiac Wheat Sensitivity: Separating the Wheat from the Chat!

Sanders

Aziz

2012

American Journal of Gastroenterology

View full text Add to dashboard Cite

Historically, it has been reported that patients with undetected celiac disease (CD) may present with irritable bowel syndrome (IBS) type symptoms. This has led to the recommendation by the American College of Gastroenterology Task force that patients presenting with diarrhea predominant IBS type symptoms should be serologically tested for CD. Concurrently speculative media data suggest that the US general public have increased their uptake of a gluten-free diet (GFD) far in excess of the known prevalence of CD. This may suggest that individuals with gastrointestinal symptoms are deriving benefi t from a GFD even if they do not have CD. This has led to the scientifi c community considering the evidence for an emerging concept of non-celiac wheat sensitivity. There is a signifi cant disparity in our views about what this phenomenon may be. There is also confusion about the nomenclature for this entity and indeed whether patients are suffering due to symptoms related to gluten or perhaps other components of wheat, for example fructans. In this month ' s edition of the American Journal of Gastroenterology , we see evidence to support the clinical concept of wheat sensitivity or intolerance. Irrespective of the nomenclature Carroccio provides a clinically applicable approach that may be adopted internationally by clinicians. This offers a new option in our armamentarium when seeing patients with IBS type symptoms.

show abstract

“…ROME III criteria consist of recurrent abdominal pain or discomfort for at least 3 months, onset at least 6 months previously and with at least two of the following: improvement with defecation, onset associated with a change in frequency of stool, and/or onset associated with a change in appearance of stool. Sub-categories are based on stool consistency as IBS with constipation, IBS with diarrhea, or IBS with mixed or alternating constipation and diarrhea [11]. Criteria exist for both children (4-18 years of age) and adults (over 18 years of age).…”

Section: Introductionmentioning

confidence: 99%

Protocol for a randomized controlled study of Iyengar yoga for youth with irritable bowel syndrome

Evans

Cousins

Tsao

et al. 2011

Trials

View full text Add to dashboard Cite

IntroductionIrritable bowel syndrome affects as many as 14% of high school-aged students. Symptoms include discomfort in the abdomen, along with diarrhea and/or constipation and other gastroenterological symptoms that can significantly impact quality of life and daily functioning. Emotional stress appears to exacerbate irritable bowel syndrome symptoms suggesting that mind-body interventions reducing arousal may prove beneficial. For many sufferers, symptoms can be traced to childhood and adolescence, making the early manifestation of irritable bowel syndrome important to understand. The current study will focus on young people aged 14-26 years with irritable bowel syndrome. The study will test the potential benefits of Iyengar yoga on clinical symptoms, psychospiritual functioning and visceral sensitivity. Yoga is thought to bring physical, psychological and spiritual benefits to practitioners and has been associated with reduced stress and pain. Through its focus on restoration and use of props, Iyengar yoga is especially designed to decrease arousal and promote psychospiritual resources in physically compromised individuals. An extensive and standardized teacher-training program support Iyengar yoga's reliability and safety. It is hypothesized that yoga will be feasible with less than 20% attrition; and the yoga group will demonstrate significantly improved outcomes compared to controls, with physiological and psychospiritual mechanisms contributing to improvements.Methods/DesignSixty irritable bowel syndrome patients aged 14-26 will be randomly assigned to a standardized 6-week twice weekly Iyengar yoga group-based program or a wait-list usual care control group. The groups will be compared on the primary clinical outcomes of irritable bowel syndrome symptoms, quality of life and global improvement at post-treatment and 2-month follow-up. Secondary outcomes will include visceral pain sensitivity assessed with a standardized laboratory task (water load task), functional disability and psychospiritual variables including catastrophizing, self-efficacy, mood, acceptance and mindfulness. Mechanisms of action involved in the proposed beneficial effects of yoga upon clinical outcomes will be explored, and include the mediating effects of visceral sensitivity, increased psychospiritual resources, regulated autonomic nervous system responses and regulated hormonal stress response assessed via salivary cortisol.Trial registrationClinicalTrials.gov NCT01107977.

show abstract

The Functional Gastrointestinal Disorders and the Rome III Process

Cited by 2,081 publications

References 97 publications

Circadian profiling reveals higher histamine plasma levels and lower diamine oxidase serum activities in 24% of patients with suspected histamine intolerance compared to food allergy and controls

Circadian profiling reveals higher histamine plasma levels and lower diamine oxidase serum activities in 24% of patients with suspected histamine intolerance compared to food allergy and controls

Editorial: Non-Celiac Wheat Sensitivity: Separating the Wheat from the Chat!

Protocol for a randomized controlled study of Iyengar yoga for youth with irritable bowel syndrome

Contact Info

Product

Resources

About