Circadian profiling reveals higher histamine plasma levels and lower diamine oxidase serum activities in 24% of patients with suspected histamine intolerance compared to food allergy and controls

Pinzer, T.C.; Tietz, Esther Bogen; Waldmann, Elisabeth; Schink, Monic; Neurath, Markus F.; Zopf, Yurdagül

doi:10.1111/all.13361

Cited by 35 publications

(37 citation statements)

References 32 publications

(65 reference statements)

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“…and illustrated the DAO activity in asthmatic children. Alternatively, many studies were done to evaluate DAO in patients with histamine intolerance (HI) …”

Section: Discussionmentioning

confidence: 99%

Diamine oxidase enzyme: a novel biomarker in respiratory allergy

Refaat

Abdel-Rehim

Elmahdi

et al. 2019

Int Forum Allergy Rhinol

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Background: Well-known allergy tests are used to evaluate and diagnose allergic diseases. The aim of this study was to assess the role of serum level diamine oxidase (DAO) enzyme as a diagnostic marker in respiratory allergy.Methods: This case-control study included 40 patients with respiratory allergies (atopic asthma and allergic rhinitis) as well as 40 age-and sex-matched controls. A detailed past medical history of allergy was collected from each participant including family history of allergy. Physical examination, pulmonary function test (PFT) and measurement of serum levels of total immunoglobulin E (IgE) and DAO were performed. Skin-prick test and specific IgE to common aeroallergens were also carried out.Results: DAO levels were higher in patients than controls. There was a positive correlation between severity of disease and DAO. No significant association was found between DAO level and age, type of respiratory allergy, duration of disease, PFT, eosinophilia, and total IgE. DAO had a high negative predictive value (94.7%) and high sensitivity (97.5%). Conclusion: DAO may be helpful in the assessment of severity and in ruling out respiratory allergy. C 2019 ARS-AAOA, LLC.R espiratory allergy is growing significantly. Estimations worldwide reveal that 5% to 12% of the population are asthmatic, whereas 20% have allergic rhinitis, which is the leading cause of decreased individual productivity. One study showed that around 45% of patients had not yet been diagnosed and that respiratory allergies were underdetermined. 1 Accurate screening and early diagnosis are crucial in the management of respiratory allergy.Mast cells are the main contributor of a typical allergic inflammatory reaction. These cells are activated by exposure to allergens, which, in turn, results in the release of many mediators including histamine, leukotrienes, and specific cytokines. 2 Histamine is the main biomarker of the

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“…and illustrated the DAO activity in asthmatic children. Alternatively, many studies were done to evaluate DAO in patients with histamine intolerance (HI) …”

Section: Discussionmentioning

confidence: 99%

Diamine oxidase enzyme: a novel biomarker in respiratory allergy

Refaat

Abdel-Rehim

Elmahdi

et al. 2019

Int Forum Allergy Rhinol

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“…The low specificity and complex variability of symptoms undoubtedly contribute to the current difficulty in achieving consensus on the diagnostic criteria for histamine intolerance, as will be discussed in detail below [ 13 ]. A lack of data also makes it difficult to determine the current incidence of this condition, although some authors have estimated that it affects 1–3% of the population, a percentage that will possibly increase as more knowledge and diagnostic tools for histamine intolerance become available [ 10 , 13 , 63 ].…”

Section: Histamine Intolerancementioning

confidence: 99%

Histamine Intolerance: The Current State of the Art

et al. 2020

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Histamine intolerance, also referred to as enteral histaminosis or sensitivity to dietary histamine, is a disorder associated with an impaired ability to metabolize ingested histamine that was described at the beginning of the 21st century. Although interest in histamine intolerance has considerably grown in recent years, more scientific evidence is still required to help define, diagnose and clinically manage this condition. This article will provide an updated review on histamine intolerance, mainly focusing on its etiology and the existing diagnostic and treatment strategies. In this work, a glance on histamine intoxication will also be provided, as well as the analysis of some uncertainties historically associated to histamine intoxication outbreaks that may be better explained by the existence of interindividual susceptibility to ingested histamine.

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“…Patients with low serum DAO values (< 10 U/mL) (12), two or more GI symptoms described for HIT, and a reduction of symptoms due to a histaminereduced diet may be diagnosed with HIT (13). Its exact prevalence is not known, but numbers of up to 3 percent in populations were estimated (14).…”

Section: Food Intolerance/malabsorptionmentioning

confidence: 99%

Food intolerance/malabsorption may occur in rare diseases

Schnedl¹,

Tillich²,

Enko

et al. 2020

IRDR

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primary epiploic appendagitis; Gullo syndrome; beta-thalassemia minor; inferior vena cava anomaly; lactose; fructose, histamine Sugars including lactose and fructose, or proteins (gluten), or biogenic amines (histamine), and combinations thereof may cause food intolerance/malabsorption. However, in usually asymptomatic patients with rare diseases, who present with functional, non-specific, non-allergic gastrointestinal (GI) complaints the etiologic factors of food intolerance/malabsorption need to be evaluated. We summarize patients with rare diseases, such as primary epiploic appendagitis, beta-thalassemias minor, Gullo syndrome and anomaly of the inferior vena cava, who presented functional, nonspecific, non-allergic GI complaints. As conclusion, these GI symptoms in patients with otherwise asymptomatic, rare diseases were due to fructose malabsorption, histamine-, lactose intolerance and Helicobacter pylori (H.p.) infection. A registered and experienced dietician was employed to design an individually-tailored diet which ensured effective treatments and H.p. infection was accordingly eradicated.

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Circadian profiling reveals higher histamine plasma levels and lower diamine oxidase serum activities in 24% of patients with suspected histamine intolerance compared to food allergy and controls

Cited by 35 publications

References 32 publications

Diamine oxidase enzyme: a novel biomarker in respiratory allergy

Diamine oxidase enzyme: a novel biomarker in respiratory allergy

Histamine Intolerance: The Current State of the Art

Food intolerance/malabsorption may occur in rare diseases

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