The functional (−1171 5A→6A) polymorphisms of <i>matrix metalloproteinase 3</i> gene as a risk factor for oral submucous fibrosis among male areca users

Tu, His-Feng; Liu, C.-J.; Chang, Che Shoa; Lui, Man Tin; Kao, Shou Yen; Chang, Chih-Yu; Liu, T.-Y.

doi:10.1111/j.1600-0714.2006.00370.x

Cited by 38 publications

(30 citation statements)

References 38 publications

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“…Relative to heterozygotes, individuals homozygous for 5A have increased MMP3 gene expression and individuals homozygous for 6A have decreased gene expression (174). The 6A genotype has been correlated with increased risk for coronary disease and progression of atherosclerosis (312), oral submucosal fibrosis (277), and celiac disease in men (179). For MMP8, an association between a minor allele haplotype and preterm premature rupture of membranes has been identified (289).…”

Section: B Mmp Polymorphismsmentioning

confidence: 99%

Matrix Metalloproteinases in Lung: Multiple, Multifarious, and Multifaceted

Greenlee¹,

Werb²,

Kheradmand³

2007

Physiological Reviews

405

330

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The matrix metalloproteinases (MMPs), a family of 25 secreted and cell surface-bound neutral proteinases, process a large array of extracellular and cell surface proteins under normal and pathological conditions. MMPs play critical roles in lung organogenesis, but their expression, for the most part, is downregulated after generation of the alveoli. Our knowledge about the resurgence of the MMPs that occurs in most inflammatory diseases of the lung is rapidly expanding. Although not all members of the MMP family are found within the lung tissue, many are upregulated during the acute and chronic phases of these diseases. Furthermore, potential MMP targets in the lung include all structural proteins in the extracellular matrix (ECM), cell adhesion molecules, growth factors, cytokines, and chemokines. However, what is less known is the role of MMP proteolysis in modulating the function of these substrates in vivo. Because of their multiplicity and substantial substrate overlap, MMPs are thought to have redundant functions. However, as we explore in this review, such redundancy most likely evolved as a necessary compensatory mechanism given the critical regulatory importance of MMPs. While inhibition of MMPs has been proposed as a therapeutic option in a variety of inflammatory lung conditions, a complete understanding of the biology of these complex enzymes is needed before we can reasonably consider them as therapeutic targets.

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Section: B Mmp Polymorphismsmentioning

confidence: 99%

Matrix Metalloproteinases in Lung: Multiple, Multifarious, and Multifaceted

Greenlee¹,

Werb²,

Kheradmand³

2007

Physiological Reviews

405

330

View full text Add to dashboard Cite

show abstract

“…Chaudhary and colleagues in their study found that the 5A allele might play an important role in the susceptibility to HNC, as individuals with 5A/5A genotype had nearly two fold risk of HNSCC (OR = 1.94) when compared to controls [28]. However, Tu and colleagues found that the 5A/5A genotype was associated with the risk of oral submucous fibrosis but not OSCC [9].…”

Section: Discussionmentioning

confidence: 93%

“…The study also concluded that the genotypic linkage among the collagen-related genes, MMPs, TIMPs, and cytokines related to OSF formation requires more information to specify the risk of OSF in areca chewers [9].…”

Section: Discussionmentioning

confidence: 99%

“…Similar to OSF, liver cirrhosis, radiation induced fibrosis, and systemic sclerosis also show imbalance in fibrotic hemostasis. Under different areca exposure history, polymorphisms of genes associated with collagen homeostasis were reported to be correlated with the risks of OSF [9]. India is the fourth largest consumer of tobacco/betel quid in the world and the third largest producer of tobacco/betel quid after China and Brazil.…”

Section: Discussionmentioning

confidence: 99%

“…The presence of the 5A allele has been associated with susceptibility for coronary heart disease, abdominal aneurysm and inflammatory disorders such as arecarelated oral submucous fibrosis, celiac disease as well as ovarian and breast carcinomas [8][9][10][11]. By contrast, the 6A allele has been associated with carotid intima-media thickening and the progression of coronary artery disease, restenosis after balloon angioplasty, angiographic coronary atherosclerotic lesion growth and stenosis suggesting that a lower expression may result in matrix accumulation, faster arterial wall thickening and plaque progression [6,12].…”

Section: Introductionmentioning

confidence: 99%

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A study on genetic polymorphism in Matrix Metalloproteinases-3 in oral submucous fibrosis patients and in healthy individuals

et al. 2017

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Background: OSF is a potentially malignant condition affecting the oral cavity and oropharynx. MMP-3 also known as Stromelysin -I is a key member of the MMP family which is responsible for degradation of collagen type II,IV,V,IX and X, proteoglycans, gelatins, fibronectin, laminin and elastin. It plays an important role in activation of pro MMP-1 into the active form of MMP-1 in malignant tissues. MMP-3 expression is low in normal tissues but it is altered during tumour formation, where remodeling of ECM is required. Purpose of the study: To assess the association of single-nucleotide polymorphisms, Adenosine (Insertion/ Deletion) in -1171 5A > 6A in the MMP-3 promoter regions of patients with oral submucous fibrosis and in healthy individuals (controls). Methods: Thirty cases of OSF were categorized according to Khanna et al classification into four groups and Twenty age and sex matched controls were included in the study. Blood samples were collected in EDTA coated vacutainers and PCR restriction analysis was done. A statistical analysis was done using Chi-square test and Fisher's exact test to assess the frequency and association of the alleles in the case-control group. Results: The result showed a statistical significance difference between the duration of habit and disease severity with polymorphisms. The result also showed a higher frequency of the 5A allele in the study group as compared to the controls. Conclusion: A long-term follow up of these patients is mandatory to see the prognosis and their susceptibility to malignancy. The positive outcome of an association of the disease with polymorphisms would result in the development of potential diagnostic and therapeutic possibilities in potentially malignant and malignant lesions.

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Matrix metalloproteinase3 gene promoter polymorphisms and their haplotypes are associated with gastric cancer risk in eastern Indian population

Dey

Stalin

Gupta

et al. 2011

Molecular Carcinogenesis

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Single nucleotide polymorphisms (SNPs) of matrix metalloproteinase3 (MMP3) promoter in the development and progression of gastric cancer of whole stomach has never been investigated in any population. We conducted a hospital-based case-control study to explore the MMP3 SNPs and their haplotypes with the risk of gastric cancer for the first time in eastern Indian population. A total of 218 gastric cancer patients and 175 healthy controls were genotyped for MMP3-1612 5A/6A (rs3025058) by PCR-RFLP and rechecked 10% by DNA sequencing. MMP3-707 A/G (rs522616) and MMP3-375 C/G (rs617819) were genotyped by DNA sequencing among 209 patients and 154 controls. MMP3-1612 5A6A genotype (P = 0.026, odds ratio (OR) = 1.756, confidence interval (CI) = 1.070-2.883), combined 5A5A and 5A6A genotype (P = 0.015, OR = 1.791, CI = 1.122-2.858) and 5A allele (P = 0.002, OR = 1.75, CI = 1.21-2.53) and; MMP3-707 GG genotype (P = < 0.0001; OR = 9.612; 95% CI = 3.403-27.147), combined GG and AG genotype (P = 0.001, OR = 2.201, CI = 1.385-3.498) and G allele (P = <0.0001, OR = 2.189, CI = 1.582-3.033) conferred significant risk for gastric cancer development. Also, tobacco addicted individuals with combined 5A5A and 5A6A genotype (P = 0.005, OR = 2.952, CI = 1.377-6.327) at -1612 position of MMP3 promoter displayed a higher risk to gastric cancer development. The genotypic combinations of all three MMP3 promoter polymorphisms and their haplotypes with increasing risk allele in a dose-dependent manner showed a potential risk for developing gastric cancer. The analyses suggested that the MMP3-707 G/G and MMP3-1612 5A/6A polymorphisms are potential independent predictors of gastric cancer risk development.

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The functional (−1171 5A→6A) polymorphisms of matrix metalloproteinase 3 gene as a risk factor for oral submucous fibrosis among male areca users

Abstract: The results indicated that the 5A genotype of MMP3 promoter was associated with the risk of OSF but not OSCC.

Cited by 38 publications

References 38 publications

Matrix Metalloproteinases in Lung: Multiple, Multifarious, and Multifaceted

Matrix Metalloproteinases in Lung: Multiple, Multifarious, and Multifaceted

A study on genetic polymorphism in Matrix Metalloproteinases-3 in oral submucous fibrosis patients and in healthy individuals

Matrix metalloproteinase3 gene promoter polymorphisms and their haplotypes are associated with gastric cancer risk in eastern Indian population

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