To a particular inline-four high-speed gasoline engine as the research object, main bearing lubrication analysis model of four-cylinder engine is based on AVL-Excite Power Unit software and couples the mechanical dynamics with lubricating fluid dynamics. On the basis of this model, we are focusing on the influence of parameters such as grease groove width on the engine main bearing lubrication performance. According to the analysis of simulation results on the minimum film thickness and maximum film pressure, and combined with the analysis report of disassembling the engine, it is easy to know why bearing bushes wear and provide the basis for the optimized design of the crankshaft main bearing. Improving design of the main bearing is more useful for operating requirement.