The frequency of tumor cells in the bone marrow and blood

Sandberg, Avery A.; Moore, George E.; Crosswhite, Lois H.; Schubarg, Jean R.

doi:10.1002/1097-0142(195811/12)11:6<1180::aid-cncr2820110612>3.0.co;2-e

Cited by 33 publications

(11 citation statements)

References 10 publications

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“…However, the exact diagnosis in such preparations cannot usually be established, since the marrow materials lack the structural features of the original tumors. Generally, based on the morphology of these cells, it is not possible to ascertain the exact source or nature of the marrow tumor cells or whether they originated from an adenocarcinoma or sarcoma [44]. In the case of sarcomas, even when tumor tissue is available the exact diagnosis may sometimes be difficult to establish including the differentiation of RMS from other tumors [1][2][3][4][5] and only arrived at through cytogenetics and/or related procedures.…”

Section: Discussionmentioning

confidence: 99%

Hematologic masquerade of rhabdomyosarcoma

et al. 2001

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We present the case of a 12-year-old boy admitted with the diagnosis of acute leukemia, but found to have an infiltration of the marrow by an alveolar rhabdomyosarcoma (RMS) as determined by the cytogenetic demonstration of a t(2;13)(q25;q14). A primary tumor could not be found. With this case as a basis, we have tabulated features of all similar cases in the literature and discuss the possible optimal approaches to establishing the correct diagnosis in such patients. Am. J. Hematol. 68:51-57, 2001.

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Section: Discussionmentioning

confidence: 99%

Hematologic masquerade of rhabdomyosarcoma

et al. 2001

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“…The reader is also referred to Sandberg, Moore, and Schubarg (1959) for illustrations of certain non-malignant cells found in the blood.…”

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The Differential Diagnosis of Tumour Cells in Circulating Blood

Alexander

Spriggs

1960

J Clin Pathol

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White-cell concentrates were made by a dextran sedimentation technique from the blood of 140 cases of malignant disease and 60 controls. The slides were searched for tumour cells and for other unusual cells with which they might be confused. Several million white cells were scanned in the slides from each case.Acceptable tumour cells were identified in the blood of seven patients, none of whom survived for more than a few months. These cells are illustrated, as well as various other cell types which may have been confused with malignant cells in the past. It is concluded that the cytology of white cell concentrates should be further explored before statistics about the occurrence of circulating tumour cells are accepted.

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“…10,[24][25][26] Clinically, the symptoms of carcinoma of the gingival surface over the mandible include a painless or painful swelling with ulceration or bleeding, whereas metastatic carcinoma to the mandible can pass unnoticed until it starts growing, although an abnormal sensation is likely to be present at the same site. 2,4,12 As a result, the diagnosis of metastasis may often be delayed, unless the lesion is discovered accidentally.…”

Section: Discussionmentioning

confidence: 99%

Mandibular metastases from follicular carcinoma of the thyroid gland: a case report

et al. 2008

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A case of metastatic thyroid carcinoma near the left mandibular ramus with a cyst-like appearance on rotational panoramic radiographs is reported. A 55-year-old woman complained of a continuous sense of incongruity for 3-4 years since extraction of the left mandibular third molar. The lesion, with apparent gingival swelling around the left second molar, was painless and was cyst-like in appearance on plain radiographs. On the basis of the radiological fi ndings, a benign odontogenic tumor was suspected, but computed tomography (CT) showed destruction of the lingual cortical bone with soft tissue invasion to the masticator space. The fi nal histopathological diagnosis was metastatic follicular carcinoma of the thyroid gland. When investigating cyst-like radiolucent lesions with thick sclerotic margins and irregular areas on plain radiographs, we recommend using CT to evaluate the effect of the lesion on cortical bone.

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The frequency of tumor cells in the bone marrow and blood

Cited by 33 publications

References 10 publications

Hematologic masquerade of rhabdomyosarcoma

Hematologic masquerade of rhabdomyosarcoma

The Differential Diagnosis of Tumour Cells in Circulating Blood

Mandibular metastases from follicular carcinoma of the thyroid gland: a case report

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