The Frequency of Rheumatic Manifestations Among the Siblings, Parents, Uncles, Aunts and Grandparents of Rheumatic and Control Patients1

Association of class II human histocompatibility leukocyte antigens with rheumatic fever.

“…Early but unconfirmed studies suggested that susceptibility to rheumatic fever followed a simple autosomal recessive pattern of inheritance (4)(5)(6), or paralleled the inheritance of ABO blood group or ABO secretor status (7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17). The pathogenesis of rheumatic fever is also thought to involve an aberrant immunological reaction, either humoral or cellular, or both, triggered by an antecedant group A streptococcal infection (18)(19)(20)(21)(22)(23)(24)(25).…”

Studies of rheumatic disease. III. Familial association and aggregation in rheumatic disease

“…A manifestation of rheumatic disease was defined as chorea, rheumatic fever, or rheumatic heart disease, and this definition is the same as that used in the two preceding articles (1,2). Detailed information for each individual in 95 2 of these families is available with respect to the date of birth, date of last observation, and the date of onset, duration, and type of each manifestation of rheumatic disease.…”

Influence of Nutrition in Experimental Infection

“…This is true for infectious disease of such diverse etiology as leprosy (8,9), rheumatic fever (10,11), poliomyelitis (12), and tuberculosis (13,14). One of the best of these studies is that of Kailman and Reisner (14) in tuberculosis.…”

“…Uninfected animals on the deficient diet and a group injected with the uninoculated medium or normal tissue are controls too frequently omitted. 10. Since nutrition studies commonly extend over a long period, the virus or other parasites should as far as possible be frozen, or frozen and dried in quantity to serve as a basis for fresh material in the continuing experiments.…”