Association of class II human histocompatibility leukocyte antigens with rheumatic fever.

Abstract

The association of class I and II HLA antigens with rheumatic fever and its manifestations was examined in 72 patients, including 48 blacks and 24 Caucasians. No significant association was found between class I antigens and rheumatic fever. In contrast, HLA-DR2 and HLA-DR4 phenotypes were encountered in a significantly higher frequency in black and Caucasian patients with rheumatic fever, respectively, compared with the control populations (P < 0.005). The most significant association (P < 0.005) of these DR antigens with a major manifestation of rheumatic fever was found for mitral insufficiency. In addition, a significant association was encountered between persistent elevation of antibody to the group A streptococcal carbohydrate and HLA-DR4 in Caucasian patients (P < 0.04) or HLA-DR2 in the black patients (P < 0.001). The frequency of HLA-DR2/ 4 heterozygotes among patients with rheumatic fever did not differ significantly from controls. These findings support the concept of a genetically determined susceptibility to rheumatic fever and, particularly, to rheumatic heart disease. The association of the clinical manifestations of rheumatic fever and the immune hyperresponsiveness to a streptococcal antigen could be ascribed to a disease-associated immune-response gene which is in linkage disequilibrium with the DR2 and DR4 alleles of HLA-DR locus on chromosome six.

Combinatorial Synthetic Peptide Vaccine Strategy Protects against Hypervirulent CovR/S Mutant Streptococci

“…However, other putative cross-reactive Ags have also been defined (27)(28)(29). The association of rheumatoid factor/RHD with several different HLA class II specificities has been previously reported (30)(31)(32), and more recently a study has demonstrated certain HLA class II alleles to be risk alleles whereas others are protective alleles (33). These findings make it likely that multiple pathogenic Ags are involved and that in different individuals different Ags pose different risks.…”

Association of human leucocyte antigens with valvar involvement and rheumatic valvar disease development in children with acute rheumatic fever

“…20,23 Çok az çalışmada RKH'nın spesifik klinik formları ile HLA sınıf II antijenleri arasındaki ilişki incelenmiştir. Sınıf II antijenleri ile romatizmal kalp hastalığı arasında gerçekten bir ilişki olup olamadığı, eğer varsa değişik etnik gruplarda değişkenlik gösterip göstermediği, veya etnik kö-kenden bağımsız olarak aynı kapak lezyonunu taşıyan hastalarda aynı olup olmadığı sorusu geçerliliğini halen korumaktadır.…”

Associação do alótipo raro C4A6 do sistema complemento com a doença cardíaca reumática

“…Estudos iniciais investigaram diferentes antígenos da classe I (25)(26)(27) . Entretanto, associações significantes foram demonstradas com os antígenos da Classe II em grupos raciais distintos (5,6) .…”

“…Vários estudos apontam a influência genética na susceptibilidade da FR e da DCR (1)(2)(3) . Além da influência familiar (2)(3)(4) , associações significantes têm sido encontradas em diferentes populações, especialmente com antígenos da classe II do complexo principal de histocompatibilidade (MHC) (5)(6)(7) . Vários estudos demonstram significante associação entre diferentes alótipos do complemento e doenças autoimunes e infecciosas, tais como artrite reumatóide, esclerose múl-tipla, lúpus eritematoso sistêmico, doença de Chagas e hanseníase (8)(9)(10)(11)(12) .…”