The frequency of maldevelopment in man

Green, Charles R.

doi:10.1016/0002-9378(64)90831-2

Cited by 18 publications

(2 citation statements)

References 67 publications

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“…Kolah, Master, and Sanghvi (1967) give ASB data for Bombay. Penrose (1957), Green (1964), and Stevenson et al (1966) quote low figures for ASB (usually less than 1 per 1,000 births in hospital) for peoples of African origin. These low incidences, which apply also in much of the far east, including Hong Kong, Fiji, Manila, and Taiwan (Wei and Chen, 1965), are here taken to represent a background incidence of unknown origin against which the 'potato effect' is set off.…”

Section: Geographical Distrbutionmentioning

confidence: 99%

Hypothesis: anencephaly and spina bifida are usually preventable by avoidance of a specific but unidentified substance present in certain potato tubers.

Renwick¹

1972

Journal of Epidemiology & Community Health

112

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Section: Geographical Distrbutionmentioning

confidence: 99%

Hypothesis: anencephaly and spina bifida are usually preventable by avoidance of a specific but unidentified substance present in certain potato tubers.

Renwick¹

1972

Journal of Epidemiology & Community Health

112

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“…Because of their apparent anatomical and epidemiological similarity and the frequency with which one type may be born to a family which has already had another, defects such as craniorachischisis, anencephaly, spina bifida, meningomyelocele, and hydrocephalus are frequently considered together in attempts to elucidate their causes. Anencephaly is the most common and shows wide variation in incidence geographically and ethnically (Green, 1964), rang- …”

mentioning

confidence: 99%

Craniorachischisis in a Partially Trisomic 11 Fetus in a family with Reproductive Failure and a Reciprocal Translocation, t(6p+;11q-)

Ym¹,

We²,

Wr³

1974

Journal of Medical Genetics

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Summary. A familial reciprocal translocation t(6p + ;l lq-) is presented, unbalanced (6p +) in the craniorachischisic propositus and balanced in his phenotypically normal father, associated with relative infertility, multiple spontaneous abortions, and failure to produce normal offspring. The karyotype-phenotype relationship is discussed with reference to other published cases of partial trisomy for the distal portion of the long arm of chromosome 11, and the concept of deletionunmasking is briefly considered. The occurrence of major neural groove closure defects due to a variety of translocations in mice is noted. The gametic segregation of balanced and unbalanced karyotypes is unique to each particular translocation making recurrence risk projections hazardous in the absence of prior experience with the particular translocation. The questions of the relative importance of genetic inheritance, chromosomal abnormalities, and many environmental factors including possible specific teratogens in causing neural groove closure anomalies are still unsettled. The paucity of published chromosome studies in these malformations is noted. We urge that cytogenetic studies with banding techniques be undertaken on these cases and their parents in order to expand basic knowledge of the role of chromosomal errors in their aetiology.Craniorachischisis, which combines anencephaly and total spina bifida with meningomyelocele, is the extreme example of defective neural groove closure. Because of their apparent anatomical and epidemiological similarity and the frequency with which one type may be born to a family which has already had another, defects such as craniorachischisis, anencephaly, spina bifida, meningomyelocele, and hydrocephalus are frequently considered together in attempts to elucidate their causes. Anencephaly is the most common and shows wide variation in incidence geographically and ethnically (Green, 1964), rang-

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Mortality and Maldevelopment

Kalter

2007

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The frequency of maldevelopment in man

Cited by 18 publications

References 67 publications

Hypothesis: anencephaly and spina bifida are usually preventable by avoidance of a specific but unidentified substance present in certain potato tubers.

Hypothesis: anencephaly and spina bifida are usually preventable by avoidance of a specific but unidentified substance present in certain potato tubers.

Craniorachischisis in a Partially Trisomic 11 Fetus in a family with Reproductive Failure and a Reciprocal Translocation, t(6p+;11q-)

Mortality and Maldevelopment

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