Mortality and Maldevelopment

Kalter, Harold

doi:10.1007/978-1-4020-5918-6

Cited by 2 publications

(1 citation statement)

References 431 publications

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“…Even more dramatic is the case of children and young adults where cardiac valve defects represent approximately 30% of all congenital cardiovascular malformations. Only in the USA, the incidence is estimated at 1–2/1000 births, and globally is around 8/1000 births (Refs 8, 9). Congenital heart defects are relatively common and serious malformations have significant impact on morbidity, mortality and healthcare costs.…”

Section: Introductionmentioning

confidence: 99%

Heart valve tissue engineering: how far is the bedside from the bench?

Sanz-García

Cruz

Mirabet³

et al. 2015

Expert Rev. Mol. Med.

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Heart disease, including valve pathologies, is the leading cause of death worldwide. Despite the progress made thanks to improving transplantation techniques, a perfect valve substitute has not yet been developed: once a diseased valve is replaced with current technologies, the newly implanted valve still needs to be changed some time in the future. This situation is particularly dramatic in the case of children and young adults, because of the necessity of valve growth during the patient's life. Our review focuses on the current status of heart valve (HV) therapy and the challenges that must be solved in the development of new approaches based on tissue engineering. Scientists and physicians have proposed tissue-engineered heart valves (TEHVs) as the most promising solution for HV replacement, especially given that they can help to avoid thrombosis, structural deterioration and xenoinfections. Lastly, TEHVs might also serve as a model for studying human valve development and pathologies.

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Section: Introductionmentioning

confidence: 99%

Heart valve tissue engineering: how far is the bedside from the bench?

Sanz-García

Cruz

Mirabet³

et al. 2015

Expert Rev. Mol. Med.

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Nonaccidental head injury in children

Al-Holou

O'Hara²,

Cohen-Gadol³

et al. 2009

PED

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Our current understanding of nonaccidental head injury in children is the result of decades of effort and the tireless work of numerous physicians. In 1860 Auguste Ambroise Tardieu, a French forensics expert, recognized important patterns of injury in children and identified nonaccidental trauma as the cause of these injuries. His work was ignored. In the years that followed, physicians continued to report these patterns of injury but were unable to identify the etiology. A fundamental misunderstanding of the usual cause of subdural hematoma (SDH) contributed to the confusion at that time. Early in the 20th century, neurosurgeons such as Wilfred Trotter recognized that SDHs were traumatic in origin. However, even Trotter's efforts to expose faults in the theories that SDHs primarily resulted from inflammatory or infectious processes were not accepted immediately. Eventually, the pattern of injuries in children was again recognized both by neurosurgeons, who began to identify an association between trauma-induced SDHs and retinal hemorrhages, and by radiologists, who began to note SDHs in conjunction with osseous lesions. Not until the 1950s and 1960s, however, did physicians begin to routinely identify nonaccidental trauma as the cause of these injuries. Following the recognition of child abuse, a pattern of injuries in conjunction with shaking was identified and is currently known as shaken baby syndrome. Since its identification, our understanding of this syndrome has been modified as a result of new medical research, legal challenges, and popular media forces.

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Mortality and Maldevelopment

Cited by 2 publications

References 431 publications

Heart valve tissue engineering: how far is the bedside from the bench?

Heart valve tissue engineering: how far is the bedside from the bench?

Nonaccidental head injury in children

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