The frequency of Helicobacter pylori infection in vitiligo patients

Çakmak, Seray Külcü; Tantoğlu, Burcu Hazar; Onan, Duru; Yorulmaz, Ahu; Tamer, Emine; Artüz, Ferda

doi:10.4103/2349-5847.172775

Cited by 4 publications

(3 citation statements)

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“…The CLO test, can consequence in fake positives for numerous reasons, contagion by other bacteria producing urease enzyme, mistaken completion of the CLO test during endoscopy, provisional reduce of bacteria due to antibiotics. As a result, when used alone, this test has low diagnostic concert [27]. For serological identification, rapid ECO test and ELFA are an uncomplicated, inexpensive more modern, successful method and because of their high specificity, sensitivity among other noninvasive test as listed in the Table 4 and can be made on frozined samples in addition this technique available in the private and public laboratories in Iraq.…”

Section: Results Of Noninvasive Testmentioning

confidence: 99%

Comparative Study for the Accuracy of Helicobacter pylori Diagnostic Methods Associated with Some Inflammatory Factors

Naji

2018

MJS

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This Study was intended to diagnose H. pyiori the major causative pathogen in gastro duodenal irritation and ulceration. Differert techniques were used invasive tests (histopathological examina-tion, rapid urea CLO test and culture) , while noninvasive tests includes (serological tests and stool antigen) in addition to determination of some immune response factors (IgM , IgG , IgA) as well as (IL – 8 and IFN – y) in Ptients Sera. According to the results of invasive diagnostic method 30/113 (26.69%) patients were considered to be infected and 83/113(73.31%) patients were considered as noninfeted was contrasted with noninvasive diagnostic method 25/113 (22.14%) patients were considered to be infected and 88/133(77.83%) patients were considered as noninfeted. In order to get the overall percentage of the infected people included in this study, we merge the results of the two methods ,so we found out that the total infected patients with H. pylori diagnosed by invasive and noninvasive methods were 42 /113 (37.2%) while the noninfected 71/113 (62.8) disseminated as 27/68(39.71%) infect-ed male ,which was privileged than the infected female when it was 15/45(33.33%). The high prevalence of H. pylori infection in the age group ranging between (46-60) in male and female. Histology (invasive teq.) and ECO rapid test (noninvasive teq.) were considered as the ‘‘best techniques ’’ for H. pylori detection, in the outlook of its high specificity, sensitivity and because it detected the major number of H. pylori-positive patients along with the other techniques used in this work. The sensitivity, specificity, positive predictive values (PPV) and negative predictive values (NPV) for histology were 100,100,100 and 94.5% , respectively, while for the ECO rapid test they were 96, 93, 91.5, and 97.14%. Culture (invasive teq.) and IgG anti H. pylori (noninvasive teq.) coming secondly in the diagnosis of H. pylori infection because they detected a little fewer number of infected patients than the first two teq. as noted above. The sensitivity, specificity, (PPV) (NPV) for Culture were 80%, 97% ,96.96% and87.5% and for IgG anti H. pylori were 85%, 91%,92.8% and 97.8%. Finally the smallest patient number was obtained from the rest of all the six teq. were used in the present work obtained from the urea CLO test and stool antigen, in-vasive and noninvasive teq. respectively. The present research found out that there were a relationship between the results of rapid anti H. pylori ECO test, antibody titer in ELFA, immunoglobulin (IgG and IgA) and (IFN-γ) , (IL-8) concentration. Also, all these data were related to the results of the histological changes and the results of the urea CLO test of patients when compared with the noninfected members. These results showed highly significant differences among patient groups in comparison with noninfect-ed group at (P. Value < 0.001). On the other hand, there were no relationship between IgM con-centration with any of the other results of diagnostic methods were used may such results consid-ered a first step for determining the susceptibility of infection and to confirame the diagnosis by use one more test in each time especialy Histology (invasive teq.) and ECO rapid test (noninva-sive teq.) correlated with estimation of (IgG and IgA) and (IFN-γ), (IL-8) concentration

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Section: Results Of Noninvasive Testmentioning

confidence: 99%

Comparative Study for the Accuracy of Helicobacter pylori Diagnostic Methods Associated with Some Inflammatory Factors

Naji

2018

MJS

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“…Rifaioğlu et al demonstrated in their study that the incidence of H. pylori infection is significantly higher in vitiligo patients (64.7%) than in the control group (33.3%) [28]. The study did not confirm an effect of H. pylori infection on vitiligo disease activity score or vitiligo involvement pattern [27,29].…”

Section: Helicobacter Pylori and Vitiligomentioning

confidence: 86%

Cutaneous manifestation of Helicobacter pylori infection

Zakrzewski¹,

Maciorkowska²,

Gładka³

et al. 2018

polp

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Helicobacter pylori is known as one of the most common bacteria in the world, affecting millions of people every year, with a prevalence among humans of about 50% worldwide. Moreover, H. pylori is well known for its gastrointestinal disorders, which nowadays are treated mostly with antibiotics, with good response. As well as these gastrointestinal diseases, H. pylori is also involved in the development of many other non-gastrointestinal diseases, including autoimmune and allergic diseases. The wide spectrum activity of H. pylori is obtained by the phenomenon of molecular mimicry, which involves induction by the chemical structures of pathogen antibodies that react both with host antigens and pathogenic microorganism antigens. The following review paper concentrates on several diseases induced by H. pylori. Chronic urticaria is characterised by recurrent itchy blisters on the skin induced by mast cells and basophilic granulocytes, which are activated by enzymes produced and released by H. pylori. Helicobacter pylori infection constitutes some groups of patients with psoriasis vulgaris and vitiligo. The aetiopathogenesis of these diseases is multifactorial, but recent studies have shown the relationship between immune system triggering by H. pylori and the occurrence those skin diseases. Helicobacter pylori, although discovered 30 years ago, is still the subject of many scientific investigations. Current studies are focused on the effects of H. pylori on organs and systems other than the gastrointestinal tract. Many pathways indicate not only negative immune reaction to H. pylori inflammation but also positive protective effects against certain diseases. This creates new preventive and therapeutic opportunities but also the need for further investigations.

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“…showed no significant relationship between H. Pylori SAT positivity and activity of vitiligo. [ 12 ]…”

mentioning

confidence: 99%

Relationship between disease activity and Helicobacter pylori infection in patients with vitiligo

Bakry

Basha

Hefnawy

et al. 2018

Indian Dermatol Online J

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The frequency of Helicobacter pylori infection in vitiligo patients

Cited by 4 publications

References 0 publications

Comparative Study for the Accuracy of Helicobacter pylori Diagnostic Methods Associated with Some Inflammatory Factors

Comparative Study for the Accuracy of Helicobacter pylori Diagnostic Methods Associated with Some Inflammatory Factors

Cutaneous manifestation of Helicobacter pylori infection

Relationship between disease activity and Helicobacter pylori infection in patients with vitiligo

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