The Frequency of Complications and the Etiology of Disease in Patients with Liver Cirrhosis in Erzurum

Topdağı, Ömer; Bilen, Nurhan

doi:10.5152/eajm.2014.25

Cited by 11 publications

(17 citation statements)

References 15 publications

(21 reference statements)

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“…Similar to this, chronic HBV (35.8%) infection was identified as the most common etiology of CLD in this study. This result was consistent with other studies conducted in Ethiopia [14,15,27]. Studies from Newzealand [28] and India [29] have also reported chronic HBV as predominant etiology of CLD.…”

Section: Discussionsupporting

confidence: 92%

Short-term clinical outcomes of patients admitted with chronic liver disease to selected teaching hospitals in Ethiopia

et al. 2019

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Background Chronic liver disease (CLD) is a progressive destruction of liver tissue with subsequent necrosis that persists for at least 6 months. In Ethiopia, despite the high burden report, data on CLD is limited. The objective of this study was to assess short-term clinical outcomes in patients admitted with chronic liver disease to three tertiary teaching hospitals in Ethiopia and to identify predictors of mortality. Methods A cohort of 109 patients admitted with CLD to three tertiary teaching hospitals in Ethiopia, were prospectively followed from the time of admission to 30-days of hospital discharge. The study was conducted from April 1, 2018, to October 5, 2018. Kaplan-Maier curve was used to estimate survival and cox-regression analysis to identify predictors of mortality. Result A total of 109 patients (80% male) diagnosed with CLD were included. Median age of the participants was 38(IQR, 30–48). The overall median length of hospital stay was 7(IQR, 4–11) days. Of the total, 39(35.8%) patients were HBsAg positive, and 12(11%) patients were anti-HCV positive. The 30-day mortality was 38(34.9%), and most of the deaths, 31(81.6%) occurred before hospital discharge. Hepatic encephalopathy at admission; being with unidentified risk factor/etiologies of CLD and total bilirubin level were independent predictors of in-hospital mortality. Patients with hepatic encephalopathy at admission had approximately 11 times increased risk of death as compared to patients without hepatic encephalopathy at admission. Similarly, the hazard of mortality was 5.8 times higher in those patients with unidentified risk factor/etiology as compared to others. The risk of dying had also increased with an increase in bilirubin (1.188[95% CI, 1.0719–1.316]) level. Conclusion Approximately one-quarter of patients with CLD died during their hospital stay, and the risk of death continued after hospital discharge. Hepatic encephalopathy at admission, unidentified risk factor/etiology and increased level of total bilirubin are poor prognostic factors. Given that more than one third the patients had HBV-infection, access to antiviral drugs could help improve the prognosis of patients with end-stage liver disease in Ethiopia, as well as prevent the progression of the disease if initiated earlier.

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Section: Discussionsupporting

confidence: 92%

Short-term clinical outcomes of patients admitted with chronic liver disease to selected teaching hospitals in Ethiopia

et al. 2019

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“…HBV plays very important role in chronic hepatitis etiology and is a major cause of LC in developing countries. In a study in 1994 from Turkey, it was shown that 75% of cases with LC were positive for HBV in Diyarbakır region [8] and HBV was identified in 47% of cirrhotic patients in another study conducted between 2007 and 2010 in Erzurum region [9]. In consistent with the previous results, we found that more than one-third of patients with LC had HBV (38.5%) as the etio-logical factor.…”

Section: Discussionsupporting

confidence: 90%

“…HCV and alcohol consumption are the major causes of LC in Western countries. However, results of two studies from our country showed that HCV was responsible in approximately 5% of cirrhotic cases in Diyarbakır in 1994 and in 11% of cases in Erzurum between 2007 and 2010 [8,9]. Our results indicating 13.3% of cases had HCV confirm the previous results.…”

Section: Discussionsupporting

confidence: 87%

Hepatitis B virus is still the most common etiologic factor of liver cirrhosis: Results from a single center in Turkey

Başyiğit¹,

Asiltürk²,

Sapmaz³

et al. 2015

Dicle Med J

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Karaciğer sirozu sebepleri yönünden önlenebilir bir hastalık olduğu için epidemiyolojisinin araştırılması önemlidir. Biz bu tek merkezli çalışmada, Türkiye'nin Orta Anadolu bölgesinde, karaciğer sirozunun etyolojik nedenlerini ve epidemiyolojik özelliklerini belirlemeyi amaçladık.Yöntemler: 1 Ocak 2011 ve 31 Eylül 2014 tarihleri arasında sağlık merkezimizdeki yataklı ve ayaktan kliniklere başvurmuş olan karaciğer sirozu tanılı hastalar kaydedildi.Bulgular: Toplam 135 hasta çalışmaya dahil edildi: ortalama yaşı 63±14.3 (minimum:15 ve maksimum:87 yaş) olan 91 erkek hasta (%67,4) ve 44 kadın hasta (%33). Sirozun temel nedenleri: Kronik hepatit B (KHB), (n:52, %38,5) ve kriptojenik, (n:33, %24,4) idi. Sirozun en sık nedeni erkeklerde KHB (%49,5) ve kadınlarda kriptojenik karaciğer sirozuydu (%40,9). Alkolik sirozu olan hastaların tamamı erkekti. Otoimmün hepatiti olan hastaların oranı kadınlarda anlamlı olarak yüksekti (%70). 50 yaş altındaki ve üstündeki sirotik hastalar arasında KHB'li hastaların oranı benzerdi (sırasıyla;%31,6 ve %39,7), ancak 50 yaş altındakilerde hepatit C virüsü olan hastaların oranı, 50 yaş üstündekilere göre anlamlı olarak daha azdı (%5,3 ve %14,7). 50 yaş altında genetik bozukluğa bağlı sirotik hasta yoktu.Sonuç: Hepatit B virüsüne karşı Ulusal aşılama programı, etkin tedavi önlemleri ve artırılmış tarama tetkiklerine rağmen, KHB halen ülkemizde en sık siroz nedenidir.

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“…In this study, hepatitis B virus is the main cause of hepatic cirrhosis (87.5%) followed by chronic alcoholism (21.59%). That predominance of post hepatitis B cirrhosis has been pointed out by Topdagi et al who reported hepatitis B as the major cause of hepatic cirrhosis in the developing countries [12]. Post hepatitis cirrhosis are the most represented (54.5%) followed by alcoholic cirrhosis (32.5%) according to Ouavene et al [11].…”

Section: Discussionmentioning

confidence: 86%

“…Bouglouga et al [4] have reported some complications like ascites, hepatocellular carcinoma and hepatic encephalopathy in respectively 60%, 26.3% and 7.5% of cases. Among the complications reported by Topdagi et al, there is an ascites predominance (83%) followed by digestive hemorrhage (56%), Peritonitis (42%), hepatic encephalopathy (26%) [12]. Xie et al [15] and Bruno et al [18] have reported an ascites predominance in respectively 60% and 76.65% of cases.…”

Section: Discussionmentioning

confidence: 92%

Epidemiological, Clinical and Paraclinical Aspects of Cirrhosis at Borgou Departmental University Hospital Center (Benin)

Dovonou¹,

Alassani²,

Saké³

et al. 2018

OJIM

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Objective: To study the epidemiological, clinical and paraclinical aspects of cirrhosis at Borgou Departmental University hospital Center. Methods: This is a retrospective study for descriptive purpose conducted in the Internal Medicine Department. The study population consists of patients hospitalized in the Internal Medicine Department during the period from 1st January 2009 to 31st December 2016. Results: The frequency of cirrhosis was 1.35%. The sex ratio was 3.76. The average age of patients was 45.22 ± 15.23 years old, with a range from 15 to 82 years. There is a post hepatitis Bcirrhosis predominance in 87.5% of cases, followed by alcoholic cirrhosis in 21.59% of cases. The complications of cirrhosis are dominated by ascites (78.4%) and jaundice (52%). Conclusion: Cirrhosis is a condition that is wide spread. The hepatitis B virusis the main cause of liver cirrhosis followed by alcoholism. Ascites is the most encountered complication. It's very important now to educate the populations for a behaviour change and to promote vaccination against viral hepatitis.

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The Frequency of Complications and the Etiology of Disease in Patients with Liver Cirrhosis in Erzurum

Cited by 11 publications

References 15 publications

Short-term clinical outcomes of patients admitted with chronic liver disease to selected teaching hospitals in Ethiopia

Short-term clinical outcomes of patients admitted with chronic liver disease to selected teaching hospitals in Ethiopia

Hepatitis B virus is still the most common etiologic factor of liver cirrhosis: Results from a single center in Turkey

Epidemiological, Clinical and Paraclinical Aspects of Cirrhosis at Borgou Departmental University Hospital Center (Benin)

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