Hepatitis B virus is still the most common etiologic factor of liver cirrhosis: Results from a single center in Turkey

Başyiğit, Sebahat; Asiltürk, Zeliha; Sapmaz, Ferdane; Kefeli, Ayşe; Yeniova, Abdullah Özgür; Uzman, Metin; Nazlıgül, Yaşar

doi:10.5798/diclemedj.0921.2015.04.0601

Cited by 5 publications

(6 citation statements)

References 9 publications

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“…The number of male patientswere more than women. This is in accordance with several previous studies which stated that there were more people with cirrhosis of the liver with HBV infection in men than in women [25][26][27] . This is due to the protective role of estrogen for the liver.…”

Section: Discussionsupporting

confidence: 94%

Associations between P53, Transforming Growth Factor Beta-1, and Interleukin-10 Serum Levels with Advanced Liver Disease and Hepatitis B Virus Infection

Citrawatidyahkencono Wungu,

Mochamad Amin,

Ulfa Kholili

et al. 2021

Indian Journal of Forensic Medicine & Toxicology

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Background. Hepatitis B infection can lead to advanced liver disease (ALD) which causes serious health problems. Several factors that are thought to play a role in advanced liver disease are P53, Transforming Growth Factor-β1 (TGF-β1), and Interleukin-10 (IL-10). Therefore, this study aimed to determine the association between P53, TGF-β1, and IL-10 serum levels with ALD.Methods. We collected 68 sera from patients with HBV infection. P53, TGF-β1, and IL-10 serum levels were measured by ELISA. We also detected SNPs from P53 and TGF-b1 genes to determines their associations. Results and Conclusions:In this study, we obtained 41.18% CH patients and 58.82% ALD patients. Male patients outnumbered female in all groups. There was a significant relationship between serum P53 and TGF-b1 levels with ALD (p = 0.03 and 0.01, respectively), but not serum IL-10 levels. However, there was no significant relationship between SNP gene P53 and serum P53 levels nor between SNP gene TGF-b1 and serum TGF-b1 levels (p = 0.73 and 0.23, respectively).Both P53 and TGF-b1 serum leveles can act as biomarkers of prognosis and target therapy for ALD patients.

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Section: Discussionsupporting

confidence: 94%

Associations between P53, Transforming Growth Factor Beta-1, and Interleukin-10 Serum Levels with Advanced Liver Disease and Hepatitis B Virus Infection

Citrawatidyahkencono Wungu,

Mochamad Amin,

Ulfa Kholili

et al. 2021

Indian Journal of Forensic Medicine & Toxicology

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“…It was found that most liver cirrhosis patients with HBV infection in this study was male (80%). This is consistent with the demographic data in previous studies suggesting that patients with cirrhosis of the liver due to chronic HBV infection are more frequent men than women [13][14][15] . This may due to a protective role of estrogen that is prevents damage to the liver because estrogen inhibits the proliferation of hepatic stellate cells and fibrogenesis that play an important role in the course of cirrhosis.…”

Section: Discussionsupporting

confidence: 93%

Detection of Tumor Necrosis Factor- (Tnf- ) Gene Promoters Polymorphism Among Liver Cirrhosis Patients With Chronic Hepatitis B Virus (Hbv) Infection in Surabaya, Indonesia

Wungu

Amin

Ruslan

et al. 2019

IJTID

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Polymorphisms in TNF-α gene promoter region are known of its role in the production of TNF-α which may influences the pathogenesis of liver disease. SNPs in positions 238 and 308 of TNF-α gene promoters may affect the production of these cytokines. This study was aimed to detect Single Nucleotide Polymorphism (SNP) on -238 and -308 positions in the TNF-α gene promoter among liver cirrhosis patients with HBV infection in Surabaya, Indonesia. This was descriptive exploratory research with cross sectional study design using serum liver cirrhosis patients with HBV infection in Endoscopy Outpatient Clinic Dr. Soetomo General Hospital, Surabaya from April-May 2017. SNPs at -238 and -308 on TNF-α gene promoter (rs361525 and rs1800629 respectively) were detected using Polymerase Chain Reaction-Restriction Fragment Length Polymorphism (PCR-RFLP) with primers specific for the TNF-α promoter region and restriction enzymes NcoI and MspI. The genotypes of TNF-α gene promoter were assessed according to the length of the fragments produced in RFLP. Serum TNF-α levels was measured by commercial ELISA. In this study, as much as 149 positive HBsAg patients was found in Endoscopy Outpatient Clinic, Dr. Soetomo General Hospital, Surabaya. From those amount, as much as 30 liver cirrhosis patients with positive HBsAg were obtained. From 2/30 (6.7%) patients showed the GA heterozygote SNP either position -238 or -308. No patient had the AA genotype. Median blood TNF-α level in women (38 ng / L) was higher than in men (33 ng / L). TNF-α levels in patients with GA heterozygote genotype at -238 and -308 in this research was not different than wild-type (GG genotype). Among patients with liver cirrhosis due to chronic HBV infection in Surabaya, Indonesia, Surabaya, we found GA polymorphisms the TNF-α promoter gene at positions -238 and -308 in 6.7% patients, and did not find homozygous AA polymorphisms. Further studies including larger numbers of patients from various ethnic backgrounds in Indonesia are needed to provide robust data on TNF-α gene promoter polymorphisms and their role in the pathogenesis of liver cirrhosis with HBV infection in this country. ABSTRAKPolimorfisme pada promotor gen TNF-α diketahui berperan pada produksi TNF-α yang selanjutnya berperan dalam patogenesis penyakit hepar, penyakit infeksi, serta inflamasi. SNP gen TNF, terutama pada posisi 238 dan 308 dari promotor gen TNF-α telah diidentifikasi dapat memengaruhi produksi sitokin tersebut. Penelitian ini merupakan penelitian pendahuluan yang dilakukan untuk mendeteksi Single Nucleotide Polymorphism (SNP) promotor gen TNF-α posisi -238 dan -308 dari sampel penderita sirosis hati dengan infeksi VHB di Poli Endoskopi RSUD Dr. Soetomo, Surabaya. Jenis penelitian ini adalah penelitian deskriptif eksploratif laboratorik dengan rancangan penelitian cross sectional study yang mengambil sampel pasien penderita sirosis hati dengan infeksi VHB di Poli Endoskopi RSUD Dr. Soetomo Surabaya dari bulan April-Mei 2017. SNP posisi -238 dan -308 (rs361525 dan rs1800629) promotor gen...

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“…Kronik hepatit B enfeksiyonu karaciğer sirozunda halen en sık nedendir 4,12,13,14 . Karaciğer sirozunda karaciğer hemodinamik değişikliklerinin tesbiti erken tanı ve progresyonunun izlenmesinde önemli yeri vardır.…”

Section: Discussionunclassified

Hepatit B’ye Bağlı Kronik Karaciğer Hastalığında Safra Kesesi Motilitesinin Değerlendirilmesi

Tuncel

2021

Dicle Tıp Dergisi

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Amaç: Çalışmamızda hepatit B'ye bağlı kronik karaciğer hastalarında portal hipertansiyonla ilişkili faktörlerin safra kesesi duvar kalınlığı ve motilitesi üzerindeki etkilerine bakıldı. Aynı zamanda antrum duvar kalınlığı ve mide motilitesi üzerindeki etkilerine bakılması amaçlandı.Yöntemler: Çalışmaya portal hipertansiyon bulguları olmayan 10 hasta kontrol, portal hipertansiyon gelişmiş 20 hasta olgu grubu olarak alındı. Batın ultrasonografiyle açlık, test yemeği sonrası 15.dk, 30.dk, 60.dk, 90.dk, 120.dk safra kesesi ve antrum duvar kalınlığı, postprandiyal safra kesesi volümleri ve ejeksiyon fraksiyonları ölçüldü. Bulgular: Hastaların 15'i Child Pugh A (%50), 10'u Child Pugh B (%35), 5'i Child Pugh C (%15) olarak sınıflandırıldı. Her iki grupta zamanla safra kesesi ejeksiyon fraksiyon oranlarının arttığı, safra kesesi volümlerin de azalma olduğu gösterildi. Sirozlu hastaların safra kesesi duvar kalınlık değişimi kontrol grubuna göre 30 ve 90. dk' larda istatistiksel anlamlı ölçüde arttığı gösterildi. Sirozlu hastalarda antrum duvar kalınlığındaki değişim oranının 15, 30. ve 120. dakikalarda istatistiksel olarak anlamlı şekilde arttığı gösterildi.Sonuç: Kronik karaciğer hastalığında safra kesesi duvar kalınlığında artma ve motilitesinde azalma olduğu saptandı. Bu sonuçlardan portal hipertansiyonun tek başına sorumlu olmadığı gösterildi. Portal hipertansiyon olan ve olmayan kronik karaciğer hastalarında safra kesesi hipomotilitesi yönünden bir fark olmadığı saptandı. Safra kesesi hipomotilitesi ve kese duvar kalınlaşmasında portal hipertansiyonla ilişkili karaciğer yetmezliğine bağlı rezervin azalması, hipoalbuminemi, safra stazı bilinen önemli nedenlerdir. Ancak portal hipertansiyon dışı nörohumoral faktörlerin de sorumlu olabileceğini düşündürdüğünden bununla ilgili ileri çalışmaların yapılması gerektiğini düşünmekteyiz.

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Hepatitis B virus is still the most common etiologic factor of liver cirrhosis: Results from a single center in Turkey

Cited by 5 publications

References 9 publications

Associations between P53, Transforming Growth Factor Beta-1, and Interleukin-10 Serum Levels with Advanced Liver Disease and Hepatitis B Virus Infection

Associations between P53, Transforming Growth Factor Beta-1, and Interleukin-10 Serum Levels with Advanced Liver Disease and Hepatitis B Virus Infection

Detection of Tumor Necrosis Factor- (Tnf- ) Gene Promoters Polymorphism Among Liver Cirrhosis Patients With Chronic Hepatitis B Virus (Hbv) Infection in Surabaya, Indonesia

Hepatit B’ye Bağlı Kronik Karaciğer Hastalığında Safra Kesesi Motilitesinin Değerlendirilmesi

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