The frequency of ABO blood group maternal-fetal incompatibility, maternal iso-agglutinins, and immune agglutinins quantitation in Osogbo, Osun State, South-West of Nigeria

Oseni, Bashiru S; Akomolafe, Oluseun F

doi:10.4103/0973-6247.75998

Cited by 4 publications

(3 citation statements)

References 8 publications

(10 reference statements)

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“…Bombay Phenotype, a rare blood type was seen in 0.2% of the cases. In our study, the frequency of ABO incompatibility was seen in 33.68%, which is comparable with the study conducted by Oseni et al in a Nigerian population (38%) 18,19 . The fetomaternal ABO incompatibility was seen in 33.68% of the cases in the present study.…”

Section: Discussionsupporting

confidence: 90%

“…The incidence of DAT positivity in newborns with ABO incompatibility was observed to be 11.2% in the present study, which is nearly twice that of the observations made by Toy et al and Dinesh D 20,21 . Various studies have shown that DAT is not a very good predictor of clinical severity for ABO HDFN cases, and it ranges from 12% to 53% with a sensitivity of 15% to 64% 16,19,20 . The methodology used for testing influences the sensitivity of the test and hence the predictive value.…”

Section: Discussionsupporting

confidence: 41%

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Clinical Implication of Immunohaematological Tests in ABO haemolytic disease of newborn: Revisiting an old disease

Das

Shastry

Pentapati

et al. 2020

Transfusion Medicine

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Objective We aimed to assess the frequency distribution of of ABO haemolytic disease of newborn (ABO‐HDN) and to know the predictive value of immunohaematological tests in identifying at risk neonates. Background ABO incompatibility, although a common cause of haemolytic disease of newborn, has several unaddressed issues related to it. Material and methods A prospective study over 20 months was carried out in a tertiary care centre in South India. Blood grouping, Direct Antiglobulin test (DAT) and elution studies were performed on neonatal samples, whereas blood grouping, antibody screening and antibody titration were performed on maternal samples. In suspected cases, ABO‐HDN was diagnosed after excluding other possible causes for haemolysis. The laboratory results were correlated with the clinical details to assess the predictive value of the tests. Results Of the total 2856 pregnancies, 34% had ABO incompatibility. On testing with columnagglutination test (CAT), the overall DAT positivity and that among ABO‐incompatible cases were 3.8% and 11.2%, respectively,) whereas by conventinal tube technique (CTT) it was 0.6% and 2.4% respectively. CAT was found to have higher sensitivity, and the predictive value was higher for CTT. Maternal IgG titre showed a positive linear relationship with the DAT strength and the rise in indirect bilirubin levels. The positive predictive value of combination of tests such as DAT, elution and titation was 94.12%, which was much higher than that of the individual tests. Conclusion DAT positivity is a predictor of early rise in serum bilirubin level, and a combination of tests has a better predictive value than individual tests towards development of clinically significant hyperbilirubinemia in ABO‐HDN.

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Section: Discussionsupporting

confidence: 90%

Section: Discussionsupporting

confidence: 41%

Clinical Implication of Immunohaematological Tests in ABO haemolytic disease of newborn: Revisiting an old disease

Das

Shastry

Pentapati

et al. 2020

Transfusion Medicine

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show abstract

“…The distribution of blood groups in a compatible population is typically 45% for blood group O, 30% for blood group A, 20% for blood group B, and 5% for blood group AB [ 4 ]. The incidence of ABO HDN is about 2% of all births, but severe hemolytic disease occurs in only 0.03% of births [ 5 ].…”

Section: Introductionmentioning

confidence: 99%

Novel Two-Infusion Pump Technique for Exchange Transfusion in a Hyperbilirubinemic Neonate

Reddy,

Rawat,

Karotkar

et al. 2024

Cureus

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Neonatal hyperbilirubinemia is a common concern in newborns, with ABO blood group incompatibility serving as a significant risk factor for severe jaundice. This case report outlines the successful management of a 2.5 kg female infant born to a primigravida mother with ABO incompatibility-induced hyperbilirubinemia. The neonate, born at 38.4 weeks via lower segment cesarean section, exhibited signs of jaundice at 91 hours of life, prompting screening and subsequent confirmation of serum bilirubin levels 26.4. The decision was made using the American Academy of Pediatrics (AAP) and categorized the child under high risk according to age and bilirubin level to implement a complete exchange transfusion using a novel approach with two infusion pumps. The unique aspect of this case lies in introducing a two-infusion pump technique, one to infuse and one to extract blood by inserting the IV set in opposite directions in the infusion pump to perform the exchange transfusion, aiming to minimize complications associated with traditional methods. Careful handling of umbilical venous and arterial lines, coupled with aseptic precautions, sought to mitigate the risk of sepsis. The procedure, conducted over two hours, demonstrated stability in vital signs and was monitored with a transcutaneous bilirubinometer. Post-transfusion, repeat serum bilirubin tests showed a decrease in bilirubin of 10.1, indicating the success of the novel exchange transfusion method. The infant was discharged after a five-day hospital stay, showcasing this innovative approach's potential efficacy and safety. This case contributes to the evolving strategies in neonatal care and emphasizes the importance of tailored interventions in managing hyperbilirubinemia associated with ABO incompatibility.

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The spectrum of ABO haemolytic disease of the fetus and newborn in neonates born to group O mothers

et al. 2022

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Background and Objectives: ABO haemolytic disease of the fetus and newborn (HDFN) is a lesser recognized entity; however, the severity may vary in neonates.This prospective observational study was performed to determine the severity and risk of ABO-HDFN in neonates born to O group mothers. Materials and Methods: A total of 260 neonates born to non-alloimmunized blood group O mothers were recruited. Blood group O neonates were excluded from the study. Neonatal direct antiglobulin test (DAT) was performed using the column agglutination technique. They were monitored for clinical and laboratory parameters and followed up at 6-8 weeks. The maternal anti-A and anti-B titres (IgM and IgG) were also done. Results: A total of 176 neonates with blood group A (77/260; 29.6%) and B (99/260; 38.1%) were finally included in the study, and 15 (8.5%) of them were DAT positive. Overall, 26.7% (47/176) neonates received phototherapy, 172 (97.7%) survived and none required readmission. The median (inter-quartile range [IQR]) maternal IgG anti-B titre (32 [32-64]) was significantly higher (p < 0.001) than the IgG anti-A titre (16 [8-64]). The maximum total serum bilirubin in neonates had a significant positive association with neonatal birth weight (p = 0.045), positive DAT (p = 0.006) and requirement of phototherapy (p < 0.001). The relative risk (95% CI) of a DAT-positive neonate requiring phototherapy was 4.55 (3.12-6.33). Conclusion:The frequency of ABO incompatibility in neonates born to group O mothers was 67.69% (176/260). The maternal IgG titre of ≥64 could be a good predictor for identifying the neonates at risk of developing hyperbilirubinaemia requiring phototherapy.

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The frequency of ABO blood group maternal-fetal incompatibility, maternal iso-agglutinins, and immune agglutinins quantitation in Osogbo, Osun State, South-West of Nigeria

Cited by 4 publications

References 8 publications

Clinical Implication of Immunohaematological Tests in ABO haemolytic disease of newborn: Revisiting an old disease

Clinical Implication of Immunohaematological Tests in ABO haemolytic disease of newborn: Revisiting an old disease

Novel Two-Infusion Pump Technique for Exchange Transfusion in a Hyperbilirubinemic Neonate

The spectrum of ABO haemolytic disease of the fetus and newborn in neonates born to group O mothers

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