The formation of urocanic acid and glutamic acid in the fermentation of histidine by <i>Clostridium tetanomorphum</i>

Wickremasinghe, R. L.; Fry, B. A.

doi:10.1042/bj0580268

Cited by 21 publications

(4 citation statements)

References 27 publications

(2 reference statements)

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“…The end-products of both glutamic acid and histidine fermentations include Hg , CO2 , NH3 , acetic and butyric acids [66], and by analogy with Edlbacher's work with liver, Woods and Clifton were the first to suggest that glutamic acid was an intermediate in the fermentation of histidine. Confirmation of this hypothesis has been recently obtained and the first step in the conversion of histidine (I) to glutamic acid, HCOOH and NH3 involves deamination to urocanic acid (II) [60]. (11) Urocanic acid and glutamic acid are also intermediates in the oxidation of histidine by Ps.…”

Section: Ch3ch2c6oh+2ch3cooh+2co0+3nh3mentioning

confidence: 73%

The Nitrogen Metabolism of Micro-organisms

Fry¹

1955

AIBS Bulletin

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CHAPTER I energy-rich phosphate group arising by a non-oxidative reaction is found in e«o/-2-phosphopyruvic acid, a substance formed by the dehydration of 2-phosphoglyceric acid under the influence of enolase. The phosphate groups and their associated energy can be transferred, in the presence of the appropriate enzyme (a phosphokinase), to adenosine diphosphate (ADP), or sometimes to adenosine monophosphate to synthesize complex organic nitrogenous compounds is especially variable, and whilst some organisms are exacting towards only one compound, e.g. Salmonella typhosa to tryptophan and Proteus vulgaris to nicotinic acid, the nutrition of other heterotrophs is far more complex, e.g. Leuconostoc mesenteroides P-60 requires eighteen amino-acids and NITROGEN METABOLISM Space available, the subject-matter of the chapter is confined to a few selected topics. In the concluding chapter the mode of action of chemotherapeutic agents is considered in terms of their observed effects on the metabolism of compounds containing nitrogen. BIBLIOGRAPHY The following books are recommended for general reading and as reference books for detailed information concerning specific topics: FOSTER, J. w. (1949), Chemical Activities of Fungi, Academic Press, U.S.A. FRY, B. A. and PEEL, J. L. (editors), (1954), Autotrophic Microorganisms, Soc. gen. Microbiol. Symp., 4, Cambridge University Press, G.B. GALE, E. F. (1949), Chemical Activities of Bacteria, University Tutorial Press, G.B. LWOFF, A. (1 95 1), Biochemistry and Physiology of Protozoa, Academic Press, U.S.A.

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Section: Ch3ch2c6oh+2ch3cooh+2co0+3nh3mentioning

confidence: 73%

The Nitrogen Metabolism of Micro-organisms

Fry¹

1955

AIBS Bulletin

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“…The organism evidently has no ability to metabolize trimethylamine. It was thought that this organism might deaminate L-2-thiolhistidine, a compound structur-ally similar to ergothioneine, forming thiolurocanic acid in a similar fashion to the deamination of histidine to urocanic acid (Tabor et at., 1952;Wickremasinghe and Fry, 1954;Hall, 1952;Mehler and Tabor, 1953). However, preliminary experiments involving growing or resting cells showed that L-2-thiolhistidine was not decomposed.…”

Section: Resultsmentioning

confidence: 99%

DEGRADATION OF ERGOTHIONEINE BY ALCALIGENES FAECALIS

Yanasugondha

Appleman

1957

J Bacteriol

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“…Presenting animals carboxyl-C14-histidine, they could isolate radioactive glutamic acid from the liver. WICKREMASINGHE and FRY ( 1954) investigated the fermentation of histidine by Clostridium tetanomorphum. They were able to demonstrate that the first reaction was a deamination of histidine to urocanic acid (XXIV).…”

Section: The Synthesis Of Glutamic Acid By a Transamination Ofmentioning

confidence: 99%

The Metabolism of Amides and Amino Acids in Etiolated Seedlings of Lupinus Luteus L.

Venekamp

1955

Acta Botanica Neerlandica

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The formation of urocanic acid and glutamic acid in the fermentation of histidine by Clostridium tetanomorphum

Cited by 21 publications

References 27 publications

The Nitrogen Metabolism of Micro-organisms

The Nitrogen Metabolism of Micro-organisms

DEGRADATION OF ERGOTHIONEINE BY ALCALIGENES FAECALIS

The Metabolism of Amides and Amino Acids in Etiolated Seedlings of Lupinus Luteus L.

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