The Formation of Rosettes in the Rat Retina

Tansley, Katharine

doi:10.1136/bjo.17.6.321

Cited by 58 publications

(24 citation statements)

References 3 publications

(2 reference statements)

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“…Improvements in visual acuity (Early Treatment Diabetic Retinopathy Treatment Study vision screening) have been reported in human patients [124]. However, the therapeutic potential of embryonic retinal sheets is limited by the difficulties associated with isolating and implanting intact tissue [23,24] and the availability of donor tissue.…”

Section: Embryonic and Fetal Retinal Sheetsmentioning

confidence: 99%

“…Both transplanted retinal cells and tissue have demonstrated the formation of rosettes within the retina [20][21][22][23]. Rosettes are abnormal orientations of photoreceptors where outer segment faces inward instead of being aligned with the RPE [22,24]. Transplantation with a scaffold has demonstrated improved survival of RPE cells [17] and improved survival [16,25] and differentiation [26] of retinal progenitor cells (RPCs).…”

Section: Introductionmentioning

confidence: 99%

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A tissue-engineered approach towards retinal repair: Scaffolds for cell transplantation to the subretinal space

Hynes

Lavik

2010

Graefes Arch Clin Exp Ophthalmol

159

135

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Section: Embryonic and Fetal Retinal Sheetsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

A tissue-engineered approach towards retinal repair: Scaffolds for cell transplantation to the subretinal space

Hynes

Lavik

2010

Graefes Arch Clin Exp Ophthalmol

159

135

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“…Retinal dysplasia can be induced experimentally by X-ray irradiation (3, 10 -12), trephining of the eye (14), photo coagulation of the retina (4), virus infection (13), and 5-iododeoxyuridine (9). However, there has been no report on the factors which affect postnatal development of the retina without retinal dysplasia.…”

Section: Discussionmentioning

confidence: 99%

Postnatal Maldevelopment of the Retina

Amemiya¹

1977

Neonatology

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The effect of certain factors on the early postnatal development of the retina was studied by electron microscopy. Although the retina of developing rats injected with sodium iodate on the 1st and 7th postnatal days showed no retardation of development of photoreceptor outer segment, it began to degenerate about 3 weeks after birth. The retina of developing rats exposed to strong light from the 1st to 5 th postnatal day revealed slight developmental retardation of the photoreceptor outer segment, and the photoreceptor outer segment began to degenerate about 3 weeks after birth. The vitamin A deficient developing rat showed developmental retardation of the photoreceptor outer segment and it began to degenerate nearly 3 weeks after birth. In spite of induction of developmental retardation of the photoreceptor outer segment of the retina, development of the photoreceptor outer segment was not completely inhibited by moderately acting factors. However, 3 weeks after birth, the photoreceptor outer segments began to degenerate. Therefore, some factors during the early postnatal period can cause the late appearance of degeneration of the retina. The characteristics of retinal degeneration are the same as those found in the retinas of adult rats which are affected by each factor. These degenerations later recover morphologically.

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“…From a previous work it was proposed that the formation of rosettes resulted from an exaggeration of the normal process of development, with an overgrowth of the cells of the inner layer of the optic cup (Tansley, 1933). Also Ida Mann (1957) concluded that the appearance of dysplasia resulted from proliferation of that part of the retina which was actively growing when the insult was applied.…”

Section: Etiopathogenesismentioning

confidence: 99%

Retinal dysplasia

1981

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Retinal dysplasia is defined as an abnormal growth and differentiation of embryonic retina being more a secondary lesion rather than a disease. Clinically, the disorder may present itself in a surprisingly wide range of severity or of degree from retinal folds to vascularized masses in the vitreous cavity. The condition may appear monosymptomatically, involving only the eye, or as complex disorders with multisystemic anomalies. The histopathologic findings in this disorder recognize characteristic structural deviations of the retina and the pathogenesis seems to be related to the lack of the normal histogenesis of the pigment epithelium. Impaired genetic mechanisms seem to contribute to the etiology of some forms of retinal dysplasia.

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The Formation of Rosettes in the Rat Retina

Cited by 58 publications

References 3 publications

A tissue-engineered approach towards retinal repair: Scaffolds for cell transplantation to the subretinal space

A tissue-engineered approach towards retinal repair: Scaffolds for cell transplantation to the subretinal space

Postnatal Maldevelopment of the Retina

Retinal dysplasia

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