The Formation of Hydrogen Peroxide during Corrosion Reactions

Churchill, J. R.

doi:10.1149/1.3500289

Cited by 33 publications

(12 citation statements)

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“…The amount of H 2 O 2 formed in EBM‐2 gradually increased over time for the connected system, reaching 16 μ M after 30 min of connection whereas the amount of H 2 O 2 was negligible (<5 μ M ) for the disconnected system (Figure 3 a). While negligible, the small amount of H 2 O 2 generated in the control group may be a result of spontaneous Mg corrosion, which could generate H 2 O 2 near the Mg surface 21. A similar trend in H 2 O 2 generation was observed for samples in PBS, although comparatively larger amounts of H 2 O 2 were formed (ca.…”

Section: Methodssupporting

confidence: 59%

Magnesium Corrosion Triggered Spontaneous Generation of H₂O₂ on Oxidized Titanium for Promoting Angiogenesis

Park

Jeon

et al. 2015

Angew Chem Int Ed

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Although the use of reactive oxygen species (ROS) has been extensively studied, current systems employ external stimuli such as light or electrical energy to produce ROS, which limits their practical usage. In this report, biocompatible metals were used to construct a novel electrochemical system that can spontaneously generate H2O2 without any external light or voltage. The corrosion of Mg transfers electrons to Au-decorated oxidized Ti in an energetically favorable process, and the spontaneous generation of H2O2 in an oxygen reduction reaction was revealed to occur at titanium by combined spectroscopic and electrochemical analyses. The controlled release of H2O2 noticeably enhanced in vitro angiogenesis even in the absence of growth factors. Finally, a new titanium implant prototype was developed by Mg incorporation, and its potential for promoting angiogenesis was demonstrated.

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Section: Methodssupporting

confidence: 59%

Magnesium Corrosion Triggered Spontaneous Generation of H₂O₂ on Oxidized Titanium for Promoting Angiogenesis

Park

Jeon

et al. 2015

Angew Chem Int Ed

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“…While negligible,t he small amount of H 2 O 2 generated in the control group may be ar esult of spontaneous Mg corrosion, which could generate H 2 O 2 near the Mg surface. [21] As imilar trend in H 2 O 2 generation was observed for samples in PBS,a lthough comparatively larger amounts of H 2 O 2 were formed (ca. 50 mm)compared to those in EBM-2 ( Figure 3b).…”

Section: Methodssupporting

confidence: 51%

Magnesium Corrosion Triggered Spontaneous Generation of H₂O₂ on Oxidized Titanium for Promoting Angiogenesis

Park

Jeon

et al. 2015

Angewandte Chemie

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Although the use of reactive oxygen species (ROS) has been extensively studied, current systems employe xternal stimuli such as light or electrical energy to produce ROS,which limits their practical usage.Inthis report, biocompatible metals were used to construct anovel electrochemical system that can spontaneously generate H 2 O 2 without any external light or voltage.T he corrosion of Mg transfers electrons to Audecorated oxidized Ti in an energetically favorable process, and the spontaneous generation of H 2 O 2 in an oxygen reduction reaction was revealed to occur at titanium by combined spectroscopic and electrochemical analyses.T he controlled release of H 2 O 2 noticeably enhanced in vitro angiogenesis even in the absence of growth factors.F inally,an ew titanium implant prototype was developed by Mg incorporation, and its potential for promoting angiogenesis was demonstrated.

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“…Thus, the combined effect of a chemically unstable surface oxide and a thermodynamically driven force to corrode is most likely the reason behind the high reactivity and dissolution of the Co NPs. During the electrochemical corrosion process also intermediate products such as H 2 O 2 (Churchill 1939) form that contribute to the high oxidative damage potential of Co NPs. A thorough analysis of Co release/dissolution at different experimental conditions showed, for example, a high effect of sonication.…”

Section: Discussionmentioning

confidence: 99%

Mechanistic insight into reactivity and (geno)toxicity of well-characterized nanoparticles of cobalt metal and oxides

et al. 2018

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An increasing use of cobalt (Co)-based nanoparticles (NPs) in different applications and exposures at occupational settings triggers the need for toxicity assessment. Improved understanding regarding the physiochemical characteristics of Co metal NPs and different oxides in combination with assessment of toxicity and mechanisms may facilitate decisions for grouping during risk assessment. The aim of this study was to gain mechanistic insights in the correlation between NP reactivity and toxicity of three different Co-based NPs (Co, CoO, and CoO) by using various tools for characterization, traditional toxicity assays, as well as six reporter cell lines (ToxTracker) for rapid detection of signaling pathways of relevance for carcinogenicity. The results showed cellular uptake of all NPs in lung cells and induction of DNA strand breaks and oxidative damage (comet assay) by Co and CoO NPs. In-depth studies on the ROS generation showed high reactivity of Co, lower for CoO, and no reactivity of CoO NPs. The reactivity depended on the corrosion and transformation/dissolution properties of the particles and the media highlighting the role of the surface oxide and metal speciation as also confirmed by in silico modeling. By using ToxTracker, Co NPs were shown to be highly cytotoxic and induced reporters related to oxidative stress (Nrf2 signaling) and DNA strand breaks. Similar effects were observed for CoO NPs but at higher concentrations, whereas the CoO NPs were inactive at all concentrations tested. In conclusion, our study suggests that Co and CoO NPs, but not CoO, may be grouped together for risk assessment.

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The Formation of Hydrogen Peroxide during Corrosion Reactions

Cited by 33 publications

References 0 publications

Magnesium Corrosion Triggered Spontaneous Generation of H₂O₂ on Oxidized Titanium for Promoting Angiogenesis

Magnesium Corrosion Triggered Spontaneous Generation of H₂O₂ on Oxidized Titanium for Promoting Angiogenesis

Magnesium Corrosion Triggered Spontaneous Generation of H₂O₂ on Oxidized Titanium for Promoting Angiogenesis

Mechanistic insight into reactivity and (geno)toxicity of well-characterized nanoparticles of cobalt metal and oxides

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The Formation of Hydrogen Peroxide during Corrosion Reactions

Cited by 33 publications

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Magnesium Corrosion Triggered Spontaneous Generation of H2O2 on Oxidized Titanium for Promoting Angiogenesis

Magnesium Corrosion Triggered Spontaneous Generation of H2O2 on Oxidized Titanium for Promoting Angiogenesis

Magnesium Corrosion Triggered Spontaneous Generation of H2O2 on Oxidized Titanium for Promoting Angiogenesis

Mechanistic insight into reactivity and (geno)toxicity of well-characterized nanoparticles of cobalt metal and oxides

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Product

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Magnesium Corrosion Triggered Spontaneous Generation of H₂O₂ on Oxidized Titanium for Promoting Angiogenesis

Magnesium Corrosion Triggered Spontaneous Generation of H₂O₂ on Oxidized Titanium for Promoting Angiogenesis

Magnesium Corrosion Triggered Spontaneous Generation of H₂O₂ on Oxidized Titanium for Promoting Angiogenesis