The formation of an anti-restenotic/anti-thrombotic surface by immobilization of nitric oxide synthase on a metallic carrier

Alagem-Shafir, M.; Kivovich, E.; Tzchori, Itai; Lanir, Naomi; Falah, Mizied; Flugelman, Moshe Y.; Dinnar, Uri; Lotan, Noah; Sivan, Uri

doi:10.1016/j.actbio.2013.12.043

Cited by 15 publications

(11 citation statements)

References 61 publications

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“…Enhancing the attachment of NO groups on the surface may provide a method to mitigate in-stent restenosis. It is known that nitric oxide (NO) has potent anti-platelet aggregating activity, and has been widely studied for preventing restenosis and thrombus formation on the surface implantable devices such as stents [46–48]. …”

Section: Resultsmentioning

confidence: 99%

A chemical stability study of trimethylsilane plasma nanocoatings for coronary stents

Jones

Chen

2016

Journal of Biomaterials Science, Polymer Edition

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In this study, trimethylsilane (TMS) plasma nanocoatings were deposited onto 316L stainless steel coupons in direct current (DC) and radio frequency (RF) glow discharges and additional NH3/O2 plasma treatment to tailor the coating surface properties. The chemical stability of the plasma nanocoatings were evaluated after 12 week (~3 month) storage under dry condition (25 °C) and immersion in simulated body fluid (SBF) at 37 °C. It was found that nanocoatings did not impact surface roughness of underlying stainless steel substrates. X-ray photoelectron spectroscopy (XPS) and Fourier transform infrared spectroscopy (FTIR) were used to characterize surface chemistry and compositions. Both DC and RF TMS plasma nanocoatings had Si– and C– rich composition; and the O– and N– contents on the surfaces were substantially increased after NH3/O2 plasma treatment. Contact angle measurements showed that DC TMS nanocoating with NH3/O2 treatment generated very hydrophilic surfaces. DC TMS nanocoatings with NH3/O2 treatment showed minimal surface chemistry change after 12 week immersion in SBF. However, nitrogen functionalities on RF-TMS coating with NH3/O2 post treatment were not as stable as in DC case. Cell culture studies revealed that the surfaces with DC coating and NH3/O2 post treatment demonstrated substantially improved proliferation of endothelial cells over the 12 week storage period at both dry and wet conditions, as compared to other coated surfaces. Therefore, DC nanocoatings with NH3/O2 post treatment may be chemically stable for long-term properties, including shelf-life storage and exposure to the bloodstream for coronary stent applications.

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Section: Resultsmentioning

confidence: 99%

A chemical stability study of trimethylsilane plasma nanocoatings for coronary stents

Jones

Chen

2016

Journal of Biomaterials Science, Polymer Edition

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“…New types of stents (Polymer-coated drug eluting stents and nitric oxidecoated bioactive stents) are developed for preventing neo-intimal hyperplasia and reducing the rates of restenosis. Studies about efficacy and effectivity of nitric oxide-coated bioactive stents are still ongoing [29].…”

Section: Discussionmentioning

confidence: 99%

Impact of previous percutaneous coronary intervention on postoperative outcomes of coronary artery bypass grafting

Yalçın¹,

Ay²,

Türk³

et al. 2016

Eur Res J

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Objectives. The widespread use of percutaneous coronary intervention (PCI) has resulted in an increasing number of patients who have undergone prior PCI being referred for coronary artery bypass graft grafting (CABG). The aim of this study was to determine the association between previous PCI and early and midterm outcomes after CABG. Methods. A total of 54 patients undergoing elective CABG (group 1) between January 2008 and January 2009 were compared to 46 patients who had a history of bare metal stent implantation before CABG (group 2). Mean follow-up was 12 months. Results. The average time interval to CABG following initial PCI was 18.5 months. There was no significant difference in demographic features and risk factors between the two groups (p>0.05). There were also no significant differences in intraoperative and postoperative data, and no significant differences for in-hospital mortality, cardiac mortality and total mortality and in the number of rehospitalizations for cardiac or for all-cause reasons (p>0.05). Conclusions. In this study, previous PCI did not significantly influence the outcomes of CABG in a 12-month follow-up period.

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“…Another example is the complex system intended for releasing a drug to prevent blood vessel restenosis at the defined location of a vascular stent. This was achieved by using the enzyme nitric oxide synthase immobilized onto the stent, which then locally converts the non‐active prodrug L‐Arginine into the active drug nitric oxide 3 . Still another example is of the system intended not to achieve, but to prevent the burst effect in releasing recombinant methionyl human glial cell line‐derived neurotrophic factor from poly‐lactide‐co‐glycolide microparticles prepared by the spontaneous emulsification technique 4 …”

Section: Introductionmentioning

confidence: 99%

“…This was achieved by using the enzyme nitric oxide synthase immobilized onto the stent, which then locally converts the non-active prodrug L-Arginine into the active drug nitric oxide. 3 Still another example is of the system intended not to achieve, but to prevent the burst effect in releasing recombinant methionyl human glial cell line-derived neurotrophic factor from poly-lactide-co-glycolide microparticles prepared by the spontaneous emulsification technique. 4 Within the context of the general considerations and concepts mentioned above, our research specifically addresses controlled drug delivery in the field of ophthalmology.…”

mentioning

confidence: 99%

Controlled and time‐scheduled drug delivery: Polyanhydride‐based nanoparticles as ocular medication carriers

Sheskin

Geyer

Lotan

et al. 2021

Polymers for Advanced Techs

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Nanoparticles offer an ideal opportunity for the efficient local anesthetic drug delivery required during and after ocular procedures. Currently available local anesthetic drugs are short acting, which may prevent adequate ocular pain control. Therefore, development of sustained controlled release anesthetic devices for pain control over a relatively short period (up to 48 h) potentially meets various opthalmological analgesic requirements. This study presents preliminary findings for drug delivery using poly(sebacic acid) (PSA) nanoparticles for tetracaine and lidocaine administration.Tetracaine-or lidocaine-loaded PSA nanoparticles were prepared using a double emulsion methodology. Release profiles were similar for both formulations, with 50% cumulative release achieved after 17 h and 23 h for tetracaine and lidocaine, respectively.The release profiles were studied, and data obtained from in vitro experiments were fit to different mathematical models. Based on mathematical models used in this study, drug release from all PSA-based formulations was diffusion-controlled, best described by the Higuchi model. Based on preliminary experiments, a hybrid formulation providing a burst effect was designed to counter the fast adsorption of drug expected in the physiological system. This was achieved by coating the lidocaine-loaded PSA nanoparticles with a gelatin/lidocaine layer. The coating provided accelerated lidocaine release, with 50% cumulative release obtained as early as 7 h compared to 23 h for uncoated nanoparticles. This formulation provided a triphasic release that can treat different pain levels at predetermined timelines. Our results provide new insight into the benefits of using polyanhydrides as a platform for drug delivery in ophthalmology.

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The formation of an anti-restenotic/anti-thrombotic surface by immobilization of nitric oxide synthase on a metallic carrier

Cited by 15 publications

References 61 publications

A chemical stability study of trimethylsilane plasma nanocoatings for coronary stents

A chemical stability study of trimethylsilane plasma nanocoatings for coronary stents

Impact of previous percutaneous coronary intervention on postoperative outcomes of coronary artery bypass grafting

Controlled and time‐scheduled drug delivery: Polyanhydride‐based nanoparticles as ocular medication carriers

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