The formation of 14C-labelled estriol from 16-14C-estradiol-17β by human fetal liver slices

Estriol Biosynthesis by Sow Ovary

“…The formation of estriol from estradiol-17/3 by human fetal liver slices has been demonstrated by Engel et al (1958) and also with isolated rat livers (Hagopian and Levy, 1958). Surprisingly enough, no estriol biosynthesis has been observed from estradiol-17/3 in adult liver (Engel et al, 1958;Ryan and Engel, 1953).…”

“…The formation of estriol from estradiol-17/3 by human fetal liver slices has been demonstrated by Engel et al (1958) and also with isolated rat livers (Hagopian and Levy, 1958). Surprisingly enough, no estriol biosynthesis has been observed from estradiol-17/3 in adult liver (Engel et al, 1958;Ryan and Engel, 1953). Ryan (1959) has been able to show conversion of C-16oxygenated steroids to estriol in human placenta, while in a preliminary note the conversion of 16ahydroxyprogesterone to estriol in sow ovary was reported (Kadis, 1964).…”

16α HYDROXYLATION OF DEHYDROEPIANDROSTERONE BY HUMAN FETAL TISSUES

“…Furthermore, human fetal adrenal (Villee et al, 1961;Villee and Villee, 1964;Villee and Driscoll, 1965;Villee, 1965;Bird et al, 1966;Nakayama et al, 1966a) and liver tissues (Breuer, 1959;Engel et al, 1959 andSlaunwhite et al, 1965;Nakayama et al, 1965;Heinrichs et al, 1966;Bolte et al, 1966) are known to possess the ability to carry out 16ahydroxylation of various steroids.…”