Estriol Biosynthesis by Sow Ovary

Kadis, Barney

doi:10.1021/bi00900a041

Cited by 11 publications

(2 citation statements)

References 18 publications

(15 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It was also found in porcine ovarian tissue (64,65) and in studies of the feto placental unit (66,67). The third A 16-C2i-steroid identified in our studies (16-DPa) has, to our knowledge, not been described before, but the isomers, 3(3-hydroxy-5a-pregn-16-en-20-one and 3a-hydroxy-5/3-pregn-16-en-20-one, have been isolated (59,72).…”

Section: Discussionmentioning

confidence: 83%

Studies on Steroids in Urine of the Male Newborn

Schindler¹,

Wuchter²

1975

Neonatology

View full text Add to dashboard Cite

Four different methods of isolation and purification were utilized to study steroids in urine of male newborns which was collected during the first 5 days of life. These methods included celite column, ion exchange column and thin-layer chromatography, solvolysis and enzyme hydrolysis with β-glucuronidase and aryl sulfatase. Procedural losses were evaluated by using radioactive internal standards. Final quantitation of each steroid was achieved by comparison of its chromatographic and quantitative behavior with the respective standard steroids on various gas-liquid chromatography systems, either as parent compound or as trimethylsilyl ether derivative. The following steroids were found in the amounts indicated: progesterone, 2.1 μg/l (pool I), 4.6 μg/l (pool III); pregnanediol, 625.0 μg/l (pool IIa), 605.0 μg/l (pool IIb glucuronide), 25.4 μg/l (pool IIb sulfate), 4.2 μg/l (pool IIb free), 729.0 μg/l (pool III); 16α-hydroxyprogesterone, 713.0 μg/l (pool III); 16α-hydroxypregnenolone, 14,000.0 μg/l (pool III); 16α-hydroxydehydro-epiandrosterone, 2,350.0 μg/l (pool III); 16-dehydroprogesterone, 155.0 μg/l (pool I), 21.2 μg/l (pool IIb glucuronide), 97.5 μg/l (pool IIb sulfate), 5.3 μg/l (pool III); 16-de-hydropregnenolone, 382.0 μg/l (pool I), 1,380 μg/l (pool IIb glucuronide), 172.0 μg/l (pool IIb sulfate), 174.0 μg/l (pool III); 16-dehydropregnanolone, 8.3 μg/l (pool I), 239.0 μg/l (pool IIb sulfate). Pregnenolone, pregnanolone, 17α-hydroxyprogesterone and 17α-hydroxypregnenolone could not be detected. The results support the concept that the steroid patterns of urine of the newborn and amniotic fluid are very similar and that the amniotic fluid steroid content is mainly dependent on fetal urinary steroid excretion. The data on Δ¹⁶-C₂₁ -steroids are discussed.

show abstract

Section: Discussionmentioning

confidence: 83%

Studies on Steroids in Urine of the Male Newborn

Schindler¹,

Wuchter²

1975

Neonatology

View full text Add to dashboard Cite

show abstract

“…The exogenous proges terone administered could be metabolized by the maternal ovary into estrogens [15,16] which, along with the estrogens synthe sized by the placenta [17], could then pass into the fetal circulation to stimulate fetal splenic erythropoiesis. There is little sup port, however, for this contention.…”

Section: Discussionmentioning

confidence: 99%

Morphological Observations of the Fetal Rat Spleen during Prolonged Gestation

Thliveris¹,

Petriuk²,

Anderson³

et al. 1983

Cells Tissues Organs

View full text Add to dashboard Cite

The ultrastructure of splenic cells and frequency of cell types were examined in fetal rats during progesterone-induced (P23, 24, 25) and surgically-induced (S23, 24, 25) prolonged gestation, and compared to term (T) fetuses and newborn animals (N₁ N₂, N₃). Statistical analysis revealed an increase in numbers of erythroblasts and a decrease in numbers of neutrophils in post-term fetuses distinct from that seen in term and newborn animals. However, there were also significant differences between the post-term groups: the frequency of erythrocytes and total number of cells were higher in the drug-treated group, despite similar splenic weights in the two. The results are interpreted as a response by the spleen (increased erythropoiesis) to fetal hypoxia, which is known to exist during prolonged gestation.

show abstract

Reduced Estriol Excretion in Patients With Breast Cancer Prior to Endocrine Therapy

Lemon¹

1966

JAMA

116

View full text Add to dashboard Cite

Estriol Biosynthesis by Sow Ovary

Cited by 11 publications

References 18 publications

Studies on Steroids in Urine of the Male Newborn

Studies on Steroids in Urine of the Male Newborn

Morphological Observations of the Fetal Rat Spleen during Prolonged Gestation

Reduced Estriol Excretion in Patients With Breast Cancer Prior to Endocrine Therapy

Contact Info

Product

Resources

About