The Formation and Subsequent Rearrangement of 7-Chloro-5-phenyl-3,1,4-benzoxadiazepin-2(1H)-one

Elaboration of Benzoxadiazepine and Benzotriazocine Scaffolds

“…[11][12][13][14][15][16] The first publication about the synthesis of these fused seven-membered heterocycles was reported in 1962 by Sulkowski and Childress. [17] They described the treatment of 2-amino-5- [1,3,5] oxadiazepine in a moderate yield (46%, Scheme 2). [18] One year later, based on Kaneko's work, Sternbach developed two other examples of photochemical isomerization of quinazoline 3-Noxides to benzo[f] [1,3,5]oxadiazepines, in higher yields (83%).…”

“…[11][12][13][14][15][16] The first publication about the synthesis of these fused seven-membered heterocycles was reported in 1962 by Sulkowski and Childress. [17] They described the treatment of 2-amino-5- In 1967, Kaneko and Yamada described the photolysis of 4phenylquinazoline-3-oxides to benzo[f][1,3,5]-oxadiazepines. The reaction is carried out in benzene under irradiation for 6 h with a 200 W mercury lamp to give the expected benzo[f] [1,3,5] oxadiazepine in a moderate yield (46%, Scheme 2).…”

Facile Intramolecular Cyclization of N‐(2‐Hydroxybenzoyl)hydrazones to N,N′‐Diacetyl Benzo‐1,3,4‐oxadiazepine Derivatives

“…Furthermore, they have been found to exhibit diverse pharmacological effects, including antimicrobial, anticancer, herbicides and cytotoxicity activities . In many cases, benzoxadiazepines are reported as intermediates in the synthesis of benzoxazole, benzimidazoles and quinazolines . Although there have been reports that describe benzoxadiazepines and their activities as stimulant to the central nervous system, muscle relaxant, tranquilizer, anticonvulsant, pesticides or antibacterial, the synthesis of these heterocycles has scarcely been reported in the literature.…”

Heteropolyacids as Green and Reusable Catalysts for the Synthesis of 3,1,5-Benzoxadiazepines

“…They have also been reported as antibacterial and anti-inflammatory agents, pesticides and insecticides [11]. Few methods are reported in the literature for the synthesis of benzoxadiazepines [12][13][14]. During the course of our studies towards the development of HPAs as efficient heterogeneous catalysts [15- …”