The Follow-Up Period

Hanscom, Donald H.; Buchman, E

doi:10.1016/s0016-5085(19)33459-6

Cited by 25 publications

(4 citation statements)

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“…Hanscom and Buchman (1971) in a follow up study of 377 healed gastric ulcer patients found a 42% incidence of recurrence within 2 years, with complications of gastric ulcer occurring in 22 patients and three ulcer-associated deaths. Morgan et al (1978) found a similar ulcer recurrence rate of 44% after 2 years in patients on no specific therapy, using endoscopy in symptomatic patients.…”

Section: Discussionmentioning

confidence: 99%

The effect of cimetidine on the maintenance of healing of gastric ulceration

Kinloch

Pearson

Woolf³

et al. 1984

Postgraduate Medical Journal

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SummaryThe rate of endoscopically confirmed gastric ulcer relapse was compared in two groups of patients with newly healed benign gastric ulcers, receiving either cimetidine 400 mg nocte or matching placebo, over a period of 1 year. Six of 24 (25%) patients on cimetidine and 16 of 27 (59%) patients on placebo had endoscopicafly confirmed relapse. These included two patients in each group with asymptomatic relapses. The difference in the rate of relapse between the two groups was statistically significant (P=0-01).

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Section: Discussionmentioning

confidence: 99%

The effect of cimetidine on the maintenance of healing of gastric ulceration

Kinloch

Pearson

Woolf³

et al. 1984

Postgraduate Medical Journal

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“…The consumption of Rennies tablets was small. Severity of symptoms was scored as follows: no pain -0, mild pain -1, moderate pain Caved-S (50) 30 (60%) 44 (88%) 6 (12%) Cimetidine 5033 (66%) 47 (94%) 3 (6%) -2, and severe -3. The maximum weekly pain score is therefore 21 for day pain and 21 for night pain.…”

Section: Healing Studymentioning

confidence: 99%

Comparison between cimetidine and Caved-S in the treatment of gastric ulceration, and subsequent maintenance therapy.

Morgan¹,

McAdam²,

Pacsoo³

et al. 1982

Gut

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SUMMARY One hundred patients with benign gastric ulceration were treated in a single-blind, endoscopically controlled trial to assess the relative efficacy of cimetidine (1 g daily) and Caved-S (six tablets daily). Ulcer healing was assessed after six weeks' treatment, and, if incomplete, after a further six weeks. There was no significant difference between the two drug regimens (approximately 63% at six weeks and 91% at 12 weeks). If an ulcer remains unhealed after 12 weeks' treatment the patient should undergo surgery. There was no difference in the relief of day pain between the two drug regimens but cimetidine was more effective over the first two weeks of treatment in relieving night pain, than was Caved-S (p<002). After ulcer healing, drug dosage was reduced (cimetidine to 400 mg at night and Caved-S to two tablets twice daily). So far, 56 patients, 28 in each group, have completed the first year's maintenance treatment, and there have been four ulcer recurrences in each group (14%).Carbenoxolone until comparatively recently was the drug of choice for the treatment of gastric ulceration.' In 1978 we published the results of a study2 in which patients under the age of 60 years were treated with either cimetidine or carbenoxolone and those over 60 with cimetidine or Caved-S. Cimetidine was found to be more effective than carbenoxolone. The healing rates for Caved-S and cimetidine were similar. Caved-S contains deglycyrrhizinated liquorice and thus has none of the potential side-effects of carbenoxolone3 (fluid retention, congestive heart failure, hypokalaemia, and hypertension).Following this study, we decided that, before Caved-S could be unreservedly recommended for the treatment of gastric ulceration, a further trial was required, this time incorporating larger treatment groups and patients of all ages. The results of this trial form the basis of this paper.

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“…The U.S. Veterans study suggested that gastric ulcer with coexistent duodenal ulcer was especially likely to relapse21 and (somewhat unsurprisingly) that ulcers which failed to heal during short-term treatment were especially likely to give further trouble.16 Relapse has been said to be more frequent in the young than in the old and in men than in women,22 23 but the Veterans study showed no effect of age, nor that initial ulcer size or site were important determinants ofrecurrence. 20 Clinical attempts to prevent recurrence have largerly dependedupon advice about stopping smoking, avoidingso-called ulcerogenic drugs, and getting regular meals. Sensible as this advice may seem it has little or no practical justification.…”

Section: Oesophageal Cancer In Chinamentioning

confidence: 99%

Editorial: Gastric ulcer--short-term healing and long-term response.

1975

BMJ

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The Follow-Up Period

Cited by 25 publications

References 0 publications

The effect of cimetidine on the maintenance of healing of gastric ulceration

The effect of cimetidine on the maintenance of healing of gastric ulceration

Comparison between cimetidine and Caved-S in the treatment of gastric ulceration, and subsequent maintenance therapy.

Editorial: Gastric ulcer--short-term healing and long-term response.

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