Comparison between cimetidine and Caved-S in the treatment of gastric ulceration, and subsequent maintenance therapy.

Abstract

SUMMARY One hundred patients with benign gastric ulceration were treated in a single-blind, endoscopically controlled trial to assess the relative efficacy of cimetidine (1 g daily) and Caved-S (six tablets daily). Ulcer healing was assessed after six weeks' treatment, and, if incomplete, after a further six weeks. There was no significant difference between the two drug regimens (approximately 63% at six weeks and 91% at 12 weeks). If an ulcer remains unhealed after 12 weeks' treatment the patient should undergo surgery. There was no difference in the relief of day pain between the two drug regimens but cimetidine was more effective over the first two weeks of treatment in relieving night pain, than was Caved-S (p<002). After ulcer healing, drug dosage was reduced (cimetidine to 400 mg at night and Caved-S to two tablets twice daily). So far, 56 patients, 28 in each group, have completed the first year's maintenance treatment, and there have been four ulcer recurrences in each group (14%).Carbenoxolone until comparatively recently was the drug of choice for the treatment of gastric ulceration.' In 1978 we published the results of a study2 in which patients under the age of 60 years were treated with either cimetidine or carbenoxolone and those over 60 with cimetidine or Caved-S. Cimetidine was found to be more effective than carbenoxolone. The healing rates for Caved-S and cimetidine were similar. Caved-S contains deglycyrrhizinated liquorice and thus has none of the potential side-effects of carbenoxolone3 (fluid retention, congestive heart failure, hypokalaemia, and hypertension).Following this study, we decided that, before Caved-S could be unreservedly recommended for the treatment of gastric ulceration, a further trial was required, this time incorporating larger treatment groups and patients of all ages. The results of this trial form the basis of this paper.

Unravelling the Potential of Herbal Therapy for Polycystic Ovarian Disorder

“…The scientific name for liquorice, Glycyrrhiza, is derived from the Greek words "glykos" meaning "sweet" and "rhiza" meaning "root". The natural sweetness of the plant makes it a popular ingredient in desserts, beverages, and desserts [53][54][55] .…”

Long‐term maintenance treatment of gastric ulcers with ranitidine

“…Morgan ef al. 24 reported that 41 % of patients with gastric ulcer had only a short history of the disease, while 32% had had ulcer problems for more than 5 years. These results are very similar to those of the present study, in which 43 % of patients had a short history and 32 % had symptoms of ulcer disease for more than 5 years.…”

The refractory ulcer

“…The data on GU recurrence have been summarized by Brooks [22]: without active treatment, 40-50% recur in the first year after healing. When Hz-receptor antagonists are given, the recurrence rates at 1 year in 5 series have been 35% [4], 20% [5], 14% [8], 20% [12], and 14% [15].…”

“…Included in this category are those ulcers that recur within 1 year despite long-term treatment with Hz-receptor antagonists or sucralfate. Twenty to 30% of DU and GU pursue this refractory long-term course [2,[4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19].3. Those in which the cycle of remission and exacerbation is dominated by prolonged exacerbations and short or absent remissions.…”