The flavonoids of the Fagonia arabica-complex (zygophyllaceae)

El-Negoumy, Sabry I.; Al-Wakeel, S.A.M.; El-Hadidi, M.N.; Saleh, Nabiel A.M.

doi:10.1016/s0031-9422(00)81712-4

Cited by 33 publications

(11 citation statements)

References 3 publications

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“…Three triterpenoid of oleanane group, triterpenoid saponin mixture containing saponin A, B, and C, 5 substituted 8-methoxyflavones, and 2 erythroxan-type diterpene, fagonone (16-O-acetylflagonone), and minerals, namely, Zn, Na, Mn, Fe, P, K, Ca, Cu, vitamin C, protein, amino acids (alanine, arginine, glycine, isoleucine, leucine, lysine, phenylalanine, proline, tyrosine, valine) were also found. 15,[30][31][32][33] Through characterization of the phytochemicals identified in FA5 with reference to the reported phytochemicals, the most active component could be identified and analyzed for anticoagulation.…”

Section: Phytoconstituentmentioning

confidence: 99%

Effect of Aqueous Extract and Fractions of Fagonia arabica on In Vitro Anticoagulant Activity

Chourasia

Kashyap

Deopujari

et al. 2013

Clin Appl Thromb Hemost

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Fagonia arabica (FA) is a deobstruent and blood purifier, which possesses thrombolytic and antioxidant activities. In this study, the anticoagulant effects of FA and its derived fractions were evaluated. Plasma recalcification was performed with multisolvent extracts of FA and then with extracts prepared successively with increasing polarity of the solvents. Aqueous extract was the most potent anticoagulant extract, which was fractionated by thin-layer chromatography and column chromatography. Five fractions collected were checked for their anticoagulation effect. The most potent fraction was screened for phytoconstituents. Aqueous extract of FA is the most active anticoagulant (31 minutes). Results were statistically significant when compared to heparin (38 minutes) and saline (4.04 minutes; P > .001). The Fifth fraction (FA5), the most potent fraction (27 minutes), was found positive for flavonoids, saponin, tannin, triterpenoids, carbohydrates, reducing sugar, and monosaccharides. Aqueous FA and fraction FA5 were most active in in vitro anticoagulation, and any of the phytochemicals identified could be considered the active component.

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Section: Phytoconstituentmentioning

confidence: 99%

Effect of Aqueous Extract and Fractions of Fagonia arabica on In Vitro Anticoagulant Activity

Chourasia

Kashyap

Deopujari

et al. 2013

Clin Appl Thromb Hemost

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“…Both El-Negoumy et al (1986) and El-Ansari et al (1988) have reported the presence of flavonoids, namely 7-O-glycosides of apigenin and luteolin, in the flowers of Cynara spp. Considering that most of the flavonoid-Oglycosides are water soluble (Markham, 1982), the primary aim of the present study was to detect and characterise the flavonoid-7-O-glycoside composition of the aqueous extracts of the flowers from Cynara spp.…”

Section: Introductionmentioning

confidence: 96%

“…leaves have been extensively studied, studies of the composition of their flowers are less common (El-Negoumy, El Sayed, & Saleh, 1986;El-Ansari, ElNegoumy, & Saleh, 1988) and, apart from the studies on the specific enzymes and the work of Barbosa (1983), no references were found relating to the chemical composition of aqueous extracts of the flowers from Cynara spp.…”

Section: Introductionmentioning

confidence: 99%

Preliminary observations of flavonoid glycosides from the vegetable coagulant Cynara L. in protected designation of origin cheeses

Roseiro

Viala

Besle

et al. 2005

International Dairy Journal

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“…2. Such glycosides have previously been detected in other Fagonia species [16,29]. An unidentified iridoid-like compound (▶ Fig.…”

Section: Resultsmentioning

confidence: 59%

“…Crude phytochemical extracts and isolated compounds from F. cretica display a diverse range of biological activities including, amongst others, antihaemorrhagic, antitumour, anti-inflammatory, and neuroprotective effects [21][22][23][24]. Active metabolites including the anti-inflammatory and anti-tumour triterpenes taraxerol and ursolic acid [25,26], and triterpenoid saponins with hederagenin and ursolic acid and oleanoic acid aglycones, have been isolated and the general presence of flavonoids has been shown [27][28][29]. In 2012, Lam et al [30] demonstrated that an aqueous extract of F. cretica induces DNA damage, cell arrest, and apoptosis in MCF-7 (WT-p53) and MDA-MB-231 (mutant-p53) breast cancer cells.…”

Section: Antidiabetic Activities Of An Lc/ms Fingerprinted Aqueous Exmentioning

confidence: 99%

Antidiabetic Activities of an LC/MS Fingerprinted Aqueous Extract of Fagonia cretica L. in Preclinical Models

et al. 2017

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Diabetes mellitus is a chronic disease and one of the most important public health challenges facing mankind. is a medicinal plant used widely in the Punjab in Pakistan. A recent survey has demonstrated that traditional healers and herbalists frequently use this plant to treat diabetes. In the current study, the traditional medicine was prepared as a tea, and the profile of the main metabolites present in the traditional medicine was analysed via LC/MS/MS. The extract was shown to contain a number of phenolic glycosides including quercetin-3-O-rutinoside, kaempferol-3-O-rutinoside, kaempferol-3-O-glycoside, kaempferol-3(6'-malonylglucoside), isorhamnetin-3-O-rutinoside, and isorhamnetin 3-(6″-malonylglucoside) in addition to two unidentified sulphonated saponins. The traditional medicine inhibits-glucosidase with an IC of 4.62 µg/mL. The hypoglycaemic effect of the traditional medicine was evaluated in normoglycaemic and streptozotocin-treated diabetic rats, using glibenclamide as an internal control. The preparation (250 or 500 mg/kg body weight) was administered once a day for 21 consecutive days. The dose of 500 mg/kg was effective in the management of the disease, causing a 45 % decrease in the plasma glucose level at the end of the experimental period. Histological analysis of pancreatic sections confirmed that streptozotocin/nictotinamide treatment caused destruction of pancreatic islet cells, while pancreatic sections from the treatment groups showed that both the extract and glibenclamide partially prevented this deterioration. The mechanism of this protective effect is unclear. However, such a finding suggests that ingestion of the tea could confer additional benefits and should be investigated further.

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The flavonoids of the Fagonia arabica-complex (zygophyllaceae)

Cited by 33 publications

References 3 publications

Effect of Aqueous Extract and Fractions of Fagonia arabica on In Vitro Anticoagulant Activity

Effect of Aqueous Extract and Fractions of Fagonia arabica on In Vitro Anticoagulant Activity

Preliminary observations of flavonoid glycosides from the vegetable coagulant Cynara L. in protected designation of origin cheeses

Antidiabetic Activities of an LC/MS Fingerprinted Aqueous Extract of Fagonia cretica L. in Preclinical Models

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