The flavonoid chrysin protects against zearalenone induced reproductive toxicity in male mice

Fabbro, Lucian Del; Jessé, Cristiano Ricardo; Gomes, Marcelo Gomes de; Filho, Carlos Borges; Donato, Franciele; Souza, Leandro Cattelan; Góes, André Rossito; Furian, Ana Flávia; Boeira, Silvana Peterini

doi:10.1016/j.toxicon.2019.04.004

Cited by 26 publications

(13 citation statements)

References 59 publications

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“…CHR alleviated reproductive toxicity caused by PbAc, increased sperm motility and decreased dead and abnormal sperm percentages. Previous scientific studies have reported that CHR has protective effects on the reproductive system, which correlates with our results (Aksu et al., 2018; Del Fabbro et al., 2019).…”

Section: Discussionsupporting

confidence: 93%

Chrysin protects against testicular toxicity caused by lead acetate in rats with its antioxidant, anti‐inflammatory, and antiapoptotic properties

et al. 2020

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In the present study, the protective effects of chrysin (CHR) against testicular damage caused by lead acetate (PbAc) were examined. In this way, 30 min after rats were given 25 and 50 mg/kg/b.w CHR orally for seven consecutive days, 30 mg/kg/b.w PbAc was administered orally. In biochemical analysis of testicular tissue, it was found that PbAc-reduced antioxidant parameters [glutathione peroxidase (GPx), glu

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Section: Discussionsupporting

confidence: 93%

Chrysin protects against testicular toxicity caused by lead acetate in rats with its antioxidant, anti‐inflammatory, and antiapoptotic properties

et al. 2020

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“…In testicular tissue of mice exposed for 48h to ZEA (40mg/kg b.w.) the toxin increased the level of TNF-α, IL-1β, IL-6 and decreased the level of anti-inflammatory IL-10 cytokine [68].…”

Section: Effect Of Zea On Innate Immune Responsementioning

confidence: 91%

Zearalenone and the Immune Response

Bulgaru

Marin

Ţăranu

2021

Toxins

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Zearalenone (ZEA) is an estrogenic fusariotoxin, being classified as a phytoestrogen, or as a mycoestrogen. ZEA and its metabolites are able to bind to estrogen receptors, 17β-estradiol specific receptors, leading to reproductive disorders which include low fertility, abnormal fetal development, reduced litter size and modification at the level of reproductive hormones especially in female pigs. ZEA has also significant effects on immune response with immunostimulatory or immunosuppressive results. This review presents the effects of ZEA and its derivatives on all levels of the immune response such as innate immunity with its principal component inflammatory response as well as the acquired immunity with two components, humoral and cellular immune response. The mechanisms involved by ZEA in triggering its effects are addressed. The review cited more than 150 publications and discuss the results obtained from in vitro and in vivo experiments exploring the immunotoxicity produced by ZEA on different type of immune cells (phagocytes related to innate immunity and lymphocytes related to acquired immunity) as well as on immune organs. The review indicates that despite the increasing number of studies analyzing the mechanisms used by ZEA to modulate the immune response the available data are unsubstantial and needs further works.

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“…This may be attributed to the relatively low dose of chrysin (1) used in this research compared to studies with rodents. However, treatments of male mice for 10 days with up to 20 mg/kg of chrysin (1) had no effect on serum testosterone levels, while preventing the inhibition of testosterone production by exposure to the mycotoxin zearalenone [39]. Therefore, it has been suggested that chrysin (1) could be used to delay age-related decline in StAR expression and testosterone production from Leydig cells [26,39,40].…”

Section: Flavonesmentioning

confidence: 99%

“…However, treatments of male mice for 10 days with up to 20 mg/kg of chrysin (1) had no effect on serum testosterone levels, while preventing the inhibition of testosterone production by exposure to the mycotoxin zearalenone [39]. Therefore, it has been suggested that chrysin (1) could be used to delay age-related decline in StAR expression and testosterone production from Leydig cells [26,39,40]. Importantly, chrysin (1) failed to induce a significant increase in steroid production when MA-10 Leydig cells were co-incubated with 22(R)hydroxycholesterol [26], suggesting this flavonoid only improves the entry of cholesterol into the mitochondria by regulating StAR protein levels and has no effects on steroidogenic enzyme activity.…”

Section: Flavonesmentioning

confidence: 99%

Improvement of Testicular Steroidogenesis Using Flavonoids and Isoflavonoids for Prevention of Late-Onset Male Hypogonadism

Martin

Touaibia

2020

Antioxidants

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Androgen production, being important for male fertility, is mainly accomplished by the Leydig cells from the interstitial compartment of the testis. Testosterone plays a critical role in testis development, normal masculinization, and the maintenance of spermatogenesis. Within seminiferous tubules, appropriate Sertoli cell function is highly dependent on testicular androgen levels and is essential to initiate and maintain spermatogenesis. During aging, testosterone production by the testicular Leydig cells declines from the 30s in humans at a rate of 1% per year. This review outlines the recent findings regarding the use of flavonoids and isoflavonoids to improve testosterone production, contributing to normal spermatogenesis and preventing age-related degenerative diseases associated with testosterone deficiency. With the cumulation of information on the actions of different flavonoids and isoflavonoids on steroidogenesis in Leydig cells, we can now draw conclusions regarding the structure-activity relationship on androgen production. Indeed, flavonoids having a 5,7-dihydroxychromen-4-one backbone tend to increase the expression of the steroidogenic acute regulatory protein (StAR), being critical for the entry of cholesterol into the mitochondria, leading to increased testosterone production from testis Leydig cells. Therefore, flavonoids and isoflavonoids such as chrysin, apigenin, luteolin, quercetin, and daidzein may be effective in delaying the initiation of late-onset hypogonadism associated with aging in males.

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The flavonoid chrysin protects against zearalenone induced reproductive toxicity in male mice

Cited by 26 publications

References 59 publications

Chrysin protects against testicular toxicity caused by lead acetate in rats with its antioxidant, anti‐inflammatory, and antiapoptotic properties

Chrysin protects against testicular toxicity caused by lead acetate in rats with its antioxidant, anti‐inflammatory, and antiapoptotic properties

Zearalenone and the Immune Response

Improvement of Testicular Steroidogenesis Using Flavonoids and Isoflavonoids for Prevention of Late-Onset Male Hypogonadism

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