The Fixed Eruption

Drug eruptions

“…Patch testing on unaffected skin with the drug responsible for the fixed eruption has invariably produced negative results whilst occasionally a positive response has been obtained when the patch test has been applied to previously affected but 'healed' skin (Welsh, 1961). A blood-borne mediator has been identified as a possible cause in a phenolphthalein-induced fixed eruption (Wyatt et al, 1972) but this fails to explain why the lesions are so localized.…”

Drug Eruptions

“…Erytbenia fixuni-a typical drug reaction that recurs on the same site of the skin when the drug is readniinistered, has been observed to be due to several different drugs. The most typical causative agent are barbiturates, salicylates, phenacetin, phenylbuta/one, sulphonaniides, arsenic, antimon, loihne, mercury, antl quinine (8, 40,41). The reaction mechanism of erythema fixum has not been fully clarified (32).…”

Independent lesions of fixed eruption due to two unrelated drugs in the same patient

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Cross-sensitivities between various drugs causing fixed eruptions are well known (Welsh) and poly-sensitivities have also been recorded (Welsh, 1961;Pasricha, 1978). But occurrence of two groups oflesions in the same patient, one group reacting to one drug and the other group to another unrelated drug, is rare.

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“…Cross-sensitivities between various drugs causing fixed eruptions are well known (Welsh, 1952(Welsh, ,1955(Welsh, , 1961Dougherty, 1952;Browne, 1964;Fitzpatrick, 1965;Tarnowski, 1970;Nayyar & Pasricha, 1972;Pandhi & Bedi, 1975i Pasricha, 1978 and poly-sensitivities have also been recorded (Welsh, 1961;Pasricha, 1978). But occurrence of two groups oflesions in the same patient, one group reacting to one drug and the other group to another unrelated drug, is rare.…”