The First Reported Outbreak of Dengue Hemorrhagic Fever in Irian Jaya, Indonesia

Richards, Allen L.; Bagus, Renny; Baso, Samuel; Follows, George; Tan, Ratna; Graham, Robert; Sandjaja, Bernardus; Corwin, Andrew L.; Punjabi, Narain H.

doi:10.4269/ajtmh.1997.57.49

Cited by 38 publications

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“…4 Evidence of a second DHF outbreak in Papua, as presented in this report, again highlights the epidemic potential of these viruses in an area with no known historical experience with DHF ( Figure 1). …”

Section: Introductionsupporting

confidence: 57%

“…9 The implication as to the predominance of DEN-3 virus in association with DHF was documented in other instances of epidemic DHF occurrences in Indonesia, including the Palembang and Jayapura outbreak. 4,5 The predominance of DEN-3 virus in this and other outbreak findings throughout Indonesia may represent a sampling bias because most specimen collections have targeted inpatient populations who present more severe clinical hemorrhagic manifestations. While there may indeed be a virulence component associated with an infecting viral serotype, it is also recognized that other serotypes may be more prevalent among less severe cases.…”

Section: Hospital Case Detection Clinical Epidemiologymentioning

confidence: 93%

“…Similarly, with a decrease in average accu- As reported from the outbreak investigations in Jayapura in 1993, and in Palembang, South Sumatra in 1998, the largest proportion of recognized dengue cases were found in the population less than 15 years of age. 4,5 The near equal representation of male and female cases in the segment of the population less than 15 years old contrasted significantly with Acute cases † (n ‫ס‬ 15) 27% 33.3% (all dengue -3) Convalescing cases ‡ (n ‫ס‬ 37) 30% ND Controls § (n ‫ס‬ 32) 3% ND * ELISA ‫ס‬ enzyme-linked immunosorbent assay; PCR ‫ס‬ polymerase chain reaction; ND ‫ס‬ not done.…”

Section: Hospital Case Detection Clinical Epidemiologymentioning

confidence: 99%

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Transmission of Epidemic Dengue Hemorrhagic Fever in Easternmost Indonesia

Sukri

Laras

Wandra

et al. 2003

The American Journal of Tropical Medicine and Hygiene

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Abstract. In April 2001, a second suspected outbreak of dengue hemorrhagic fever in the easternmost region of Indonesia was investigated in Merauke, a town located in the southeastern corner of Papua, by the Indonesian Ministry of Health and the U.S. Naval Medical Research Unit No. 2. Principal case criteria of hemorrhagic disease provided for a study enrollment of 15 clinically acute and 37 convalescing subjects. Additionally, 32 comparable age/sex controls were selected from neighboring households. Laboratory diagnosis involved three testing methodologies: virus isolation by cell culture, a reverse transcriptase-polymerase chain reaction (RT-PCR) assay, and serologic assays. Antibody (IgM) to dengue virus was detected in 27% of the acute clinical cases, 30% of the convalescing cases, and only 3% of the matched controls. Dengue 3 was the only viral serotype detected from acute serum samples by the RT-PCR. The mean ± SD age of the acute and convalescing cases was 7.8 ± 5.4 years. Overall hospital records accounted for 172 suspected outbreak cases, all urban residents of Merauke with no recent travel history outside the area. The estimated outbreak-associated case fatality rate among all suspected dengue cases was 1.2%. A seven-year retrospective review of hospital records in Merauke showed negligible disease reporting involving hemorrhagic disease prior to the outbreak.

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Section: Introductionsupporting

confidence: 57%

Section: Hospital Case Detection Clinical Epidemiologymentioning

confidence: 93%

Section: Hospital Case Detection Clinical Epidemiologymentioning

confidence: 99%

See 1 more Smart Citation

Transmission of Epidemic Dengue Hemorrhagic Fever in Easternmost Indonesia

Sukri

Laras

Wandra

et al. 2003

The American Journal of Tropical Medicine and Hygiene

Self Cite

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“…Pocos estudios han incluido los síntomas respiratorios en las descripciones clínicas del dengue y, generalmente, se registran con una baja frecuencia en todos los grupos de edad (21,(23)(24)(25)(26). En el presente trabajo, estas manifestaciones aparecen en una proporción importante; sin embargo, fueron más frecuentes en otras causas de síndrome febril agudo, lo que disminuye la probabilidad de que su origen sea la infección por dengue.…”

Section: Discussionunclassified

Criterios clínicos para diagnosticar el dengue en los primeros días de enfermedad.

Díaz¹,

Martínez²,

Villar³

2006

biomedica

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Introducción. La definición de caso de dengue de la Organización Mundial de la Salud (OMS) tiene alta sensibilidad, pero es muy inespecífica. Objetivo. Formular una escala diagnóstica de mayor exactitud que la definición de la OMS para la identificación clínica temprana del dengue en áreas endémicas. Materiales y métodos. En una cohorte de adultos (>12 años) con síndrome febril agudo sin causa aparente en Bucaramanga, Colombia, compuesta por 125 casos de dengue (confirmados serológica o virológicamente) y 126 de síndrome febril de otra etiología, se determinaron las manifestaciones clínicas tempranas (en los primeros cuatro días de la enfermedad) asociadas al dengue y con ellas se formularon y evaluaron diversas combinaciones diagnósticas. Resultados. La escala compuesta por exantema, prueba de torniquete positiva, ausencia de rinorrea, artralgias, ausencia de diarrea (1 punto por cada hallazgo), recuentos de leucocitos <4.000/mm 3 (3 puntos) y plaquetas <180.000/mm 3 (2 puntos) exhibió un área bajo la curva de características operador-receptor de 81,04%, superior a la observada con los criterios de la OMS de 69,96% (p=0,0003). Con ≥3 puntos se obtuvo una sensibilidad de 95,2%; una especificidad de 27,8%; un valor diagnóstico positivo de 56,7%; un valor diagnóstico negativo de 85,4%. Con ≥6 puntos se obtuvo una sensibilidad de 70,4%; una especificidad de 78,6%; un valor diagnóstico positivo de 76,5%; un valor diagnóstico negativo de 72,8%. Con ≥8 puntos se obtuvo una sensibilidad de 42,4%; una especificidad de 96%; un valor diagnóstico positivo de 91,4%; un valor diagnóstico negativo de 62,7%. Con 9 o 10 puntos, la especificidad y el valor diagnóstico positivo fueron de 100%. Conclusión. La escala descrita puede ser útil para el diagnóstico clínico temprano del dengue en áreas endémicas.Palabras clave: dengue, diagnóstico clínico, Organización Mundial de la Salud, recuento de leucocitos, recuento de plaquetas. Clinical criteria to diagnose dengue in its early stagesIntroduction. Clinical differentiation of dengue from other diseases with similar symptoms is difficult. The case definition of the World Health Organization (WHO) has high sensitivity but its specificity is very low. Objective. A diagnostic scale was formulated for early clinical diagnosis of dengue that provided greater accuracy than that of the WHO definition. Materials and methods. A cohort of 251 adults (>12 years of age) with unspecific acute febrile syndrome was selected from clinics located in Bucaramanga, Colombia. They consisted of 125 cases of dengue (serologically and/or virologically confirmed) and 126 with other febrile diseases. Clinical manifestations encountered during the first four days of dengue disease were determined, along with the diverse diagnostic combinations that were presented. Results: The scale consisted of the following criteria: presence of rash, positive tourniquet test, absence of nasal discharge, arthralgias, absence of diarrhea (1 point for each finding), leukocyte count < 4,000/mm3 (3 points) and platelet count <1...

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“…Richards AL et al reported headache in 96.7%, back pain in 39.1%, retro-orbital pain in 13.1% of all his 72 study subjects, which are closely related to the present study. [9][10][11] None of the study subjects suffered from shortness of breath. Only a small number of group-I and group-II subjects complained of cough (18.1%), chest pain (24%) and prostration.…”

Section: Discussionmentioning

confidence: 99%

Clinical Profile and Outcome of Patients with Dengue Syndrome in Hospital Care

Mohammad¹,

Sarkar²,

Amin

et al. 2011

J. Medicine

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Dengue is a viral febrile illness, which has become a major international public health concern including Bangladesh, spectrum of illness ranging from dengue fever (DF) to life threatening dengue haemorrhagic fever (DHF), dengue shock syndrome (DSS) and ultimately death. The clinical profiling and outcome during epidemic dengue outbreak was observed in Dhaka Medical College Hospital in 2000 to 2001. One hundred and fifty patients were systematically observed. Male female ratio was 5:1 with severity of illness in younger patients. Hundred percent patients had fever with 83% having generalized weakness. The severe cases(DHF) were having sudden sustained temperature of 103 degree farenheight. Majority have abdominal symptoms(>80%) while 10% had respiratory only. Sixty percent have hepatomegaly while 40 % spleenomealy while 80% of DHF had ascites. Above 75% cases of Dengue haemorhagic fever had positive tourniquet test while melaena was the commonest mucosal bleeds. No fatality was observed in this study although variability of discharge was seen in different groups. Keyword: Clinical, Profile, Outcome, Dengue, Hospital DOI: http://dx.doi.org/10.3329/jom.v12i2.6733 JOM 2011; 12(2): 131-138

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The First Reported Outbreak of Dengue Hemorrhagic Fever in Irian Jaya, Indonesia

Cited by 38 publications

References 0 publications

Transmission of Epidemic Dengue Hemorrhagic Fever in Easternmost Indonesia

Transmission of Epidemic Dengue Hemorrhagic Fever in Easternmost Indonesia

Criterios clínicos para diagnosticar el dengue en los primeros días de enfermedad.

Clinical Profile and Outcome of Patients with Dengue Syndrome in Hospital Care

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