2012
DOI: 10.1590/s0074-02762012000500018
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Abstract: In this study, we investigated the presence of plasmid-mediated quinolone resistance (PMQR) genes among 101 ciprofloxacin-resistant urinary Escherichia coli isolates and searched for mutations in the quinolone-resistancedetermining regions (QRDRs) of the DNA gyrase and topoisomerase IV genes in PMQR-carrying isolates. Eight isolates harboured the qnr and aac(6')-Ib-cr genes (3 qnrS1, 1 qnrB19 and 4 aac(6')-Ib-cr). A mutational analysis of the QRDRs in qnr and aac(6')-Ib-cr-positive isolates revealed mutations … Show more

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Cited by 20 publications
(13 citation statements)
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“…A similar mode of resistance has been studied in detail by Lindgren et al (2003) (43). On the other hand, Paiva et al (2012) (44) studied ciprofloxacin resistance gene in plasmid DNA of uropathogenic E. coli. The evolution of fluoroquinolone resistance has been found to be involved in the accumulation of multiple mutations in several genes, and it is ultimately reflected in the phenotype of the resistant organism.…”
Section: Discussionmentioning
confidence: 99%
“…A similar mode of resistance has been studied in detail by Lindgren et al (2003) (43). On the other hand, Paiva et al (2012) (44) studied ciprofloxacin resistance gene in plasmid DNA of uropathogenic E. coli. The evolution of fluoroquinolone resistance has been found to be involved in the accumulation of multiple mutations in several genes, and it is ultimately reflected in the phenotype of the resistant organism.…”
Section: Discussionmentioning
confidence: 99%
“…This collection could provide information on the occurrence and prevalence of integrons before the misuse and overuse of antimicrobials -major contributors to the development and spread of resistance [17]. Another set (40) was isolated in 2009 from urine of women with clinical and laboratory diagnoses of community-acquired urinary tract infections in Belo Horizonte, Brazil [18]. This study was approved by Ethics Committee UFMG (178/09).…”
Section: Bacterial Strainsmentioning
confidence: 99%
“…No Brasil, foram observados os genes qnrA1, qnrB2, qnrB19, qnrS1, qnrB1 e aac(6')-Ib-cr, em cepas de origem clínica (CASTANHEIRA et al, 2007;MINARINI et al, 2008;FERRARI et al, 2011;PEIRANO et al, 2011;PAIVA et al, 2012;VIANA et al, 2013).…”
Section: Genes De Resistência a Quinolonasunclassified
“…No Brasil, o primeiro relato ocorreu em 2011, por PEIRANO et al (2011), em cepas de Escherichia coli de origem clínica. Os relatos posteriores, também foram a partir de cepas de Enterobacteriaceae provenientes de amostras clínicas(PAIVA et al, 2012;VIANA et al, 2013). Este estudo, opostamente aos anteriores realizados no país, não apresentou a variante -cr em nenhuma cepa originária de amostras clínicas, mas constatou a sua ocorrência em cepas de origem ambiental.…”
unclassified