The first organometallic carbonyl tungsten complex of antibacterial drug norfloxacin

Chen, Xiong-Bin; Ye, Qiong; Wu, Qian; Song, Yu‐Mei; Xiong, Ren‐Gen; You, Xiao‐Zeng

doi:10.1016/j.inoche.2004.10.009

Cited by 10 publications

(4 citation statements)

References 22 publications

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“… The compounds shown contain chromium 281 , manganese 176 , iron 282 , cobalt 283 , copper 284 , zinc 177 , gallium 90 , ruthenium 177 , rhodium 285 , palladium 286 , silver 287 , tungsten 288 , rhenium 289 , osmium 290 , iridium 291 , platinum 292 or gold 293 . …”

Section: Metalloantibioticsmentioning

confidence: 99%

“…For a comprehensive review of the mechanism of action accessible to metal complexes, the reader is referred to a recent review by Boros et al 170 . 281 , manganese 176 , iron 282 , cobalt 283 , copper 284 , zinc 177 , gallium 90 , ruthenium 177 , rhodium 285 , palladium 286 , silver 287 , tungsten 288 , rhenium 289 , osmium 290 , iridium 291 , platinum 292 or gold 293 .…”

Section: Useful Physicochemical Propertiesmentioning

confidence: 99%

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Metals to combat antimicrobial resistance

et al. 2023

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Bacteria, similar to most organisms, have a love–hate relationship with metals: a specific metal may be essential for survival yet toxic in certain forms and concentrations. Metal ions have a long history of antimicrobial activity and have received increasing attention in recent years owing to the rise of antimicrobial resistance. The search for antibacterial agents now encompasses metal ions, nanoparticles and metal complexes with antimicrobial activity (‘metalloantibiotics’). Although yet to be advanced to the clinic, metalloantibiotics are a vast and underexplored group of compounds that could lead to a much-needed new class of antibiotics. This Review summarizes recent developments in this growing field, focusing on advances in the development of metalloantibiotics, in particular, those for which the mechanism of action has been investigated. We also provide an overview of alternative uses of metal complexes to combat bacterial infections, including antimicrobial photodynamic therapy and radionuclide diagnosis of bacterial infections.

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Section: Metalloantibioticsmentioning

confidence: 99%

Section: Useful Physicochemical Propertiesmentioning

confidence: 99%

Metals to combat antimicrobial resistance

et al. 2023

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“…The cytotoxicity of the drug is achieved via binding strongly to the gyrase-DNA complex in the presence of Mg 2+ [15,16]. A thorough survey of the literature has revealed numerous norfloxacin containing complexes [17]; the Ca 2+ [18], Mg 2+ [18], V(II) [19], Cu(I) [20], Cu(II) [21], Zn(II) [22], Ag(I) [23], Cd(II) [24] and W [25] norfloxacin complexes have been structurally characterized and reported.…”

Section: Introductionmentioning

confidence: 99%

Different types of copper complexes with the quinolone antimicrobial drugs ofloxacin and norfloxacin: Structure, DNA- and albumin-binding

Živec¹,

Perdih²,

Turel³

et al. 2012

Journal of Inorganic Biochemistry

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“…Many researchers have reported that thiourea-based complexes show effective results against various biological activities due to the presence of thiocarbonyl moiety which affect biochemical action by the lipophilicity/hydrophilicity and electronic properties of the compounds [ 13 – 16 ]. Herein we report the synthesis, characterization, and investigation of DNA interaction, enzymatic studies, and antibacterial and antifungal activities of various metal complexes of ferrocene-based thiourea and we believe that this study will provide useful information on various biological domains and thus will be very helpful to the design of new drug.…”

Section: Introductionmentioning

confidence: 99%

Ferrocene-Based Bioactive Bimetallic Thiourea Complexes: Synthesis and Spectroscopic Studies

Ali

Yasin

Zuhra

et al. 2015

Bioinorganic Chemistry and Applications

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Bioactive 1,1′-(4,4′-di-ferrocenyl)di-phenyl thiourea and various metal complexes of this ligand have been successfully synthesized and characterized by using physicoanalytical techniques such as FT-IR and multinuclear (1H and 13C) NMR spectroscopy along with melting point and elemental analyses. The interaction of the synthesized compounds with DNA has been investigated by using cyclic voltammetric and viscometric measurements. The intercalation of the complexes into the double helix structure of DNA is presumably occurring. Viscosity measurements of the complexes have shown that there is a change in length and this is regarded as the least ambiguous and the most critical test of the binding model in solution. The relative potential of the complexes as anti-bacterial, antifungal, and inhibition agents against the enzyme, alkaline phosphatase EC 3.1.3.1, has also been assessed and the complexes were found to be active inhibitors.

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The first organometallic carbonyl tungsten complex of antibacterial drug norfloxacin

Cited by 10 publications

References 22 publications

Metals to combat antimicrobial resistance

Metals to combat antimicrobial resistance

Different types of copper complexes with the quinolone antimicrobial drugs ofloxacin and norfloxacin: Structure, DNA- and albumin-binding

Ferrocene-Based Bioactive Bimetallic Thiourea Complexes: Synthesis and Spectroscopic Studies

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