By focusing on Jews and Judaism in late antiquity, this Handbook fills a gap left by other volumes that deal with early Byzantine Christianity only. Jews interacted and competed with pagans and Christians and experienced a number of significant developments between the third and seventh centuries, which marks this period as a time of transition from antiquity to the Middle Ages: the emergence of synagogues as religious centers of local communities, the increasing significance of rabbinic Judaism and the compilation of rabbinic documents, the consolidation of Jewish Diaspora communities, and the expansion of rabbinic Judaism to Sasanian Persia (Babylonia), which eventually topped Byzantine Palestine in its importance for the development and survival of Judaism.Late antiquity, that is, the time period between the third and the seventh centuries C.E., is a particularly interesting period as far as Jews and Judaism are concerned. Within the wider contexts of the late Roman, early Byzantine, and Sasanian Persian Empires, in competition and conflict with Graeco-Roman, Christian, and Zoroastrian cultures, Jewish religious leadership structures, institutions, and practices developed that are still relevant today. Major developments occurred in this period --from small teacher-disciple circles to a distinct rabbinic group identity; from oral instruction to written documents; from synagogues as multi-functional buildings to centers of local religious communities; from the aniconism of the Second Temple period to the emergence of Jewish figurative art; from a focus on the Land of Israel to increasingly significant Diaspora communities --which indicate a transition from the time after the destruction of the Second Temple to a medieval Judaism with an established communal structure based on rabbis, synagogues, and academies.