The first international proficiency test on ketamine and norketamine in hair

Lee, Vicky W.M.; Cheng, Jackie; Cheung, Samuel T.C.; Wong, Yiu‐chung; Sin, Della Wai-mei

doi:10.1016/j.forsciint.2012.01.017

Cited by 11 publications

(4 citation statements)

References 24 publications

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“…Identication of drug abuse is typically performed by determination of residues of drugs-of-abuse in body uids (e.g., urine, sweat, oral uid and blood), nail and hair. [1][2][3] Analysis of body uids is widely used because of the relatively high concentrations of drug and metabolite residues (in blood and urine), ease of collection (for oral uid), and availability of relatively large sample volume (for urine). 2 Due to the prevalence of drug abuse, testing laboratories are required to handle a signicant number of body uid samples for law enforcement and rehabilitation purposes.…”

mentioning

confidence: 99%

“…[1][2][3] Analysis of body uids is widely used because of the relatively high concentrations of drug and metabolite residues (in blood and urine), ease of collection (for oral uid), and availability of relatively large sample volume (for urine). 2 Due to the prevalence of drug abuse, testing laboratories are required to handle a signicant number of body uid samples for law enforcement and rehabilitation purposes. To deal with the large number of samples and ensure the reliability of analytical results, a two-step strategy, preliminary screening followed by conrmatory analysis, is commonly applied.…”

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confidence: 99%

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Rapid detection and quantitation of ketamine and norketamine in urine and oral fluid by wooden-tip electrospray ionization mass spectrometry

Wang

et al. 2013

Analyst

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Drug analysis is an indispensable task in controlling drug abuse, which is a serious problem worldwide nowadays. In this study, we report a simple and rapid approach for detection and quantitation of drugs-of-abuse in urine and oral fluid by wooden-tip electrospray ionization mass spectrometry (WT-ESI-MS). We demonstrated that ketamine, one of the most common abused drugs, and its major metabolite, norketamine, in raw urine and oral fluid could be readily detected and quantified by WT-ESI-MS with only little sample preparation and no chromatographic separation, and the analytical performances, including the linear range, accuracy, precision, LOD and LOQ, were well acceptable for analysis of real samples.

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confidence: 99%

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Rapid detection and quantitation of ketamine and norketamine in urine and oral fluid by wooden-tip electrospray ionization mass spectrometry

Wang

et al. 2013

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“…An innovative microfluidics HPLC-Chip-MS/MS procedure was developed by Zhu et al to dramatically reduce analysis-time and costs and, consequently, increase the laboratory throughput [74]. It is worth noting that in forensic investigations, all efforts addressed to improve the instrumental performances should always be mediated with the assurance of high quality analytical results, as was stressed in the report of the first international proficiency test for ketamine detection in hair [75].…”

Section: Psychoactive Drugs From Pharmaceutical Productsmentioning

confidence: 99%

Role of LC–MS/MS in Hair Testing for The Determination of Common Drugs of Abuse and Other Psychoactive Drugs

et al. 2013

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Hair testing has been used in toxicological investigations for the last two decades, but only recently a remarkable extension of hair analysis to a variety of application fields was observed, besides drug abuse recognition. The dramatic improvements of LC–MS/MS instrumentation make the detection of tiny amounts of almost whatever drug in hair possible, even after single-dose intake. The progresses observed during the last 5 years in the detection of psychoactive substances in hair are reviewed herein. The literature is partitioned according to the target compounds, namely traditional drugs of abuse, new psychoactive substances and pharmaceutical psychoactive substances. The LC–MS/MS methods presented are addressed to determine a single class of drugs, with the primary aim of accurate quantitation, or to perform multiclass analysis, for rapid and effective screening protocols.

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“…If people take these two kinds of drugs, they can be determined in human urine, 1,2 blood 3,4 and hair. 5,6 Although the drug concentration in human hair is generally lower than that in urine and blood, it has better stability and can reect the drug addicts' longer retrospective period. Therefore, more and more attention has been paid to analyzing residue levels of MAM and KET in human hair samples in the forensic eld.…”

Section: Introductionmentioning

confidence: 99%

Simultaneous determination of methamphetamine and ketamine in human hair using ultrasonication and LC-ESI-MS/MS method

Huang

Zheng

et al. 2013

Anal. Methods

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A rapid and reliable method for simultaneous determination of methamphetamine (MAM) and ketamine (KET) in human hair was developed. MAM and KET in hair samples were collected using ultrasonication with methanol/5 M hydrochloric acid (HCl) for 1 hour, and detected by liquid chromatography-tandem mass spectrometry (LC-MS/MS). In this experiment, drug-free human hairs were added into standard solution and kept for 16 hours in order to minimize the difference between blank spiked samples and authentic samples. D8-MAM as internal standard, the linear ranges of MAM and KET were 1-100 pg mg À1 and 2-200 pg mg À1 with correlation coefficients greater than 0.999, respectively. The limit of detection (S/N $ 3) was 0.03 pg mg À1 for MAM and 0.06 pg mg À1 for KET, the limit of quantification was (S/N $ 10) 0.09 pg mg À1 for MAM and 0.21 pg mg À1 for KET. Accuracy evaluated by recovery spiked at three different concentrations, was in the ranges of 91-114% for MAM and 88-119% for KET.The intra-and inter-day standard deviations of all analysis results were less than 3.50%. This method was applied to analyze residue levels of MAM and KET in human hair samples.

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The first international proficiency test on ketamine and norketamine in hair

Cited by 11 publications

References 24 publications

Rapid detection and quantitation of ketamine and norketamine in urine and oral fluid by wooden-tip electrospray ionization mass spectrometry

Rapid detection and quantitation of ketamine and norketamine in urine and oral fluid by wooden-tip electrospray ionization mass spectrometry

Role of LC–MS/MS in Hair Testing for The Determination of Common Drugs of Abuse and Other Psychoactive Drugs

Simultaneous determination of methamphetamine and ketamine in human hair using ultrasonication and LC-ESI-MS/MS method

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