The first example of anti‐Diego^b found in a Polish woman with the Di(a+b–) phenotype and haemolytic disease of the newborn not requiring treatment

Abstract

All pregnant women with anti-Diegob (anti-Dib) described so far were non-Caucasians. We present the case of a Polish Di(a+b-) woman with anti-Dib, which did not bind complement, was immunoglobulin G3 (IgG3) alone and had very low functional activity. She delivered a Di(a+b+) infant with a positive direct antiglobulin test and the antibody in his serum but very mild haemolytic disease. Both parents of the pregnant woman were Di(a+b+), so were all her three children. The whole family have been living in a small village in southeastern Poland for a long time. The rare Diego phenotypes, found now and previously in Poland, suggest gene admixture introduced as a result of Poland being invaded by Mongolian-background Tatars during the past centuries.

Multiple red cell alloantibodies, including anti‐Dib, after allogeneic ABO‐matched peripheral blood progenitor cell transplantation

“…Third, although there are only single reports on clinical significance of anti‐Di b , a delayed hemolytic transfusion reaction was observed, as well as hemolytic disease of the newborn 24 . We have recently detected for the first time anti‐Di b in a Caucasian pregnant woman, who delivered a newborn with a mild hemolytic disease 26 …”

Hemolytic disease of the newborn due to anti‐Dib: a case study and review of the literature

“…As shown in Table 1, 27 cases of HDN due to Di b mismatch have been reported 1,4‐18, 20‐28 and 16 cases were from Japan 4‐18 . Among 27 cases, 10 needed NO, 6 received PHOTO with/without top‐up transfusion, 9 required ET, 1 was treated with high‐dose IVGG therapy, and 1 case was treated with both ET and high‐dose IVGG.…”

Different Types of Minor Blood Group Incompatibility Causing Haemolytic Disease of Neonates in one of the National Children’s Medical Centre in China

“…The remaining types, Diego 35 , 36 and Kidd, 37 , 38 presented typically with jaundice, anaemia after birth, and positive DAT and IAT, which helped make the confirmed diagnosis. The only case with negative DAT had multiple IUTs, which probably indicates that the laboratory results of foetal and neonatal blood type, DAT and IAT may be changed after IUTs.…”