Different Types of Minor Blood Group Incompatibility Causing Haemolytic Disease of Neonates in one of the National Children’s Medical Centre in China

Abstract

Purpose To review the neonatal cases with different types of minor blood group incompatible haemolytic diseases in China, and to improve the clinical understanding and management. Materials and Methods Seven cases from January, 1st, 2013 to December 31st, 2019 were searched out and reviewed retrospectively. All clinical data and laboratory findings were collected. Results There were totally seven cases enrolled including three cases of MNS, three of Diego, and one of Kidd combined with Rh, anti-RhE incompatibility. Among the seven cases, two had intrauterine transfusion, two underwent exchange transfusion, five received intravenous immune globulin, five cases developed anaemia, and three of them had transfusion. But among them, only four were found to have positive antibody screening and three were confirmed HDN with antibody types antenatally. Conclusion The clinical presentation is diverse. Antibody screening followed by the technique of peak systolic velocity in the fetal middle cerebral artery (MCA-PSV) helps to filter out the severe cases.

Fetal and neonatal outcome in severe alloimmunization managed with intrauterine transfusion: 18-year experience in a tertiary referral hospital in China

“…In addition, routine antenatal screening for irregular antibodies was not feasible and necessary in China due to very low prevalence of HDFN caused by non-RhD alloimmunization. However, non-RhD alloantibodies including anti-E, anti-c, and anti-M have been reported to cause severe HDFN in Chinese population (2)(3)(4).…”