The first BAFF gene cloned from the cartilaginous fish

Pang, Shuying; You, Fengtao; Zhou, Liang; Zhang, Shuangquan

doi:10.1016/j.fsi.2011.09.013

Cited by 12 publications

(13 citation statements)

References 43 publications

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“…The homologue sequences to mammalian BAFF have been reported in many teleost fish species including rainbow trout ( 41 ), zebrafish ( 120 ), mefugu ( Takifugu obscurus ) ( 121 ), Japanese sea perch ( Lateolabrax japonicus ) ( 122 ), grass carp ( Ctenopharyngodon idella ) ( 123 ), yellow grouper ( Epinephelus awoara ) ( 124 ), miiuy croaker ( Miichthys miiuy ) ( 125 ), tongue sole ( Cynoglossus semilaevis ) ( 126 ), Nile tilapia ( Oreochromis niloticus ) ( 127 ), rock bream ( Oplegnathus fasciatus ) ( 128 ), and also in cartilaginous fish such as white-spotted catshark ( Chiloscyllium plagiosum ) ( 129 ), spiny dogfish ( Squalus acanthias ) ( 130 ), and small-spotted catshark ( Scyliorhinus canicula ) ( 131 ) (summarized in Table 3 ). Interestingly, some studies have revealed that many cartilaginous and bony fish species have more than one BAFF gene ( 51 , 54 ), representing two distinct groups.…”

Section: B Cell-activating Factor Of the Tnf Familymentioning

confidence: 99%

“…Recombinant BAFF proteins have been generated in some of these fish species, such as, for example, the cartilaginous fish white-spotted catshark ( 129 ), and the teleost zebrafish ( 120 ), fugu ( 121 ), Japanese sea perch ( 122 ), yellow grouper ( 124 ), tongue sole ( 126 ), rock bream ( 128 ), or tilapia ( 127 ), to carry out functional studies. These studies have proven an increase on the number of leukocytes mediated by BAFF, although the authors did not clarify whether this was due to a promotion of cell survival or an increase on cell proliferation, and they did not demonstrate if the surviving/proliferating fish leukocytes were in fact B cells.…”

Section: B Cell-activating Factor Of the Tnf Familymentioning

confidence: 99%

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Novel Insights on the Regulation of B Cell Functionality by Members of the Tumor Necrosis Factor Superfamily in Jawed Fish

Tafalla¹,

Granja²

2018

Front. Immunol.

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Most ligands and receptors from the tumor necrosis factor (TNF) superfamily play very important roles in the immune system. In particular, many of these molecules are essential in the regulation of B cell biology and B cell-mediated immune responses. Hence, in mammals, it is known that many TNF family members play a key role on B cell development, maturation, homeostasis, activation, and differentiation, also influencing the ability of B cells to present antigens or act as regulators of immune responses. Evolutionarily, jawed fish (including cartilaginous and bony fish) constitute the first animal group in which an adaptive immune response based on B cells and immunoglobulins is present. However, until recently, not much was known about the expression of TNF ligands and receptors in these species. The sequences of many members of the TNF superfamily have been recently identified in different species of jawed fish, thus allowing posterior analysis on the role that these ligands and receptors have on B cell functionality. In this review, we summarize the current knowledge on the impact that the TNF family members have in different aspects of B cell functionality in fish, also providing an in depth comparison with functional aspects of TNF members in mammals, that will permit a further understanding of how B cell functionality is regulated in these distant animal groups.

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Section: B Cell-activating Factor Of the Tnf Familymentioning

confidence: 99%

Section: B Cell-activating Factor Of the Tnf Familymentioning

confidence: 99%

Novel Insights on the Regulation of B Cell Functionality by Members of the Tumor Necrosis Factor Superfamily in Jawed Fish

Tafalla¹,

Granja²

2018

Front. Immunol.

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“…In addition, BAFF sequences have been reported in different teleost fish species including zebrafish ( Danio rerio ) (21), mefugu ( Takifugu obscurus ) (22), Japanese sea perch ( Lateolabrax japonicus ) (23), grass carp ( Ctenopharyngodon idella ) (24), yellow grouper ( Epinephelus awoara ) (25), miiuy croaker ( Miichthys miiuy ) (26), tongue sole ( Cynoglossus semilaevis ) (27), Nile tilapia ( Oreochromis niloticus ) (28), rock bream ( Oplegnathus fasciatus ) (29), and cartilaginous fish such as white-spotted catshark ( Chiloscyllium plagiosum ) (30), spiny dogfish ( Squalus acanthias ) (31), and small-spotted catshark ( Scyliorhinus canicula ) (32). Although recombinant BAFF proteins have been produced for some of these species (21–23, 25, 27–30), many of these studies have exclusively tested the effect of recombinant fish BAFF on B cell survival using mammalian B cells (21, 22, 25, 28, 30). Furthermore, those studies, which have concluded a capacity of BAFF to induce proliferation using teleost leukocytes, have not made a distinction between proliferation and survival as they have only determined increased numbers of leukocytes after BAFF treatment and have not clearly established that the cells showing increased survival or proliferating were in fact B cells (21–23, 27, 29).…”

Section: Introductionmentioning

confidence: 99%

B Cell-Activating Factor Regulates Different Aspects of B Cell Functionality and Is Produced by a Subset of Splenic B Cells in Teleost Fish

Tafalla¹,

González²,

Castro³

et al. 2017

Front. Immunol.

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In mammals, B cell functionality is greatly influenced by cytokines released by innate cells, such as macrophages or dendritic cells, upon the early recognition of common pathogen patterns through invariant receptors. B cell-activating factor (BAFF) is one of these innate B cell-helper signals and plays a key role in the survival and differentiation of B cells. Although, evolutionarily, teleost fish constitute the first animal group in which adaptive immunity based on Ig receptors is present, fish still rely greatly on innate responses. In this context, we hypothesized that BAFF would play a key role in the control of B cell responses in fish. Supporting this, our results show that teleost BAFF recapitulates mammalian BAFF stimulating actions on B cells, upregulating the expression of membrane MHC II, improving the survival of fish naïve B cells and antibody-secreting cells, and increasing the secretion of IgM. Surprisingly, we also demonstrate that BAFF is not only produced in fish by myeloid cells but is also produced by a subset of splenic B cells. Thus, if this B cell-produced BAFF proves to be actively regulating this same B cell subset, our findings point to an ancient mechanism to control B cell differentiation and survival in lower vertebrates, which has been silenced in mammals in physiological conditions, but reemerges under pathological conditions, such as B cell lymphomas and autoimmune diseases.

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“…Regarding the BAFF and APRIL subfamily of ligands and receptors, BAFF sequences have been reported recently in different teleosts including zebrafish ( Danio rerio ) [9], mefugu ( Takifugu obscurus ) [10], Japanese sea perch ( Lateolabrax japonicus ) [11], grass carp ( Ctenopharyngodon idella ) [12], yellow grouper ( Epinephelus awoara ) [13], miiuy croaker ( Miichthys miiuy ) [14], tongue sole ( Cynoglossus semilaevis ) [15], Nile tilapia ( Oreochromis niloticus ) [16], rock bream ( Oplegnathus fasciatus ) [17], rainbow trout ( Oncorhynchus mykiss ) [18], rohu ( Labeo rohita ) [19] and cartilaginous fish such as white-spotted catshark ( Chiloscyllium plagiosum ) [20], spiny dogfish ( Squalus acanthias ) [21] and small-spotted catshark ( Scyliorhinus canicula ) [22]. APRIL sequences, on the other hand, have only been identified in channel catfish ( Ictalurus punctatus ), Atlantic salmon ( Salmo salar ) and rainbow trout [18, 22].…”

Section: Introductionmentioning

confidence: 99%

Characterization of BAFF and APRIL subfamily receptors in rainbow trout (Oncorhynchus mykiss). Potential role of the BAFF / APRIL axis in the pathogenesis of proliferative kidney disease

et al. 2017

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Proliferative kidney disease (PKD) is a parasitic infection of salmonid fish characterized by hyper-secretion of immunoglobulins in response to the presence of the myxozoan parasite, Tetracapsuloides bryosalmonae. In this context, we hypothesized that the BAFF/APRIL axis, known to play a major role in B cell differentiation and survival in mammals, could be affected by the parasite and consequently be involved in the apparent shift in normal B cell activity. To regulate B cell activity, BAFF and APRIL bind to transmembrane activator and calcium modulator and cyclophilin ligand interactor (TACI) and B cell maturation antigen (BCMA), whereas BAFF also binds to BAFF receptor (BAFF-R). In teleost fish, although some BAFF and APRIL sequences have been reported, their receptors have not been identified. Thus, as a first step in the current work, we have identified homologues to mammalian TACI, BCMA and BAFF-R in rainbow trout (Oncorhynchus mykiss), that constitute the first report of BAFF and APRIL receptor sequences in fish. Subsequently we studied the transcriptional modulation of BAFF, APRIL, and the fish-specific related cytokine, BALM and their putative receptors in fish naturally exposed to T. bryosalmonae. Finally, to gain further insights on the functional role that these cytokines play during the course of PKD, we have studied their effect on the survival of kidney IgM+ B cells and on immunoglobulin transcription. Our results support the premise that the BAFF / APRIL axis could play an important role during PKD, which may open the possibility of new therapeutic treatments against the disease.

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The first BAFF gene cloned from the cartilaginous fish

Cited by 12 publications

References 43 publications

Novel Insights on the Regulation of B Cell Functionality by Members of the Tumor Necrosis Factor Superfamily in Jawed Fish

Novel Insights on the Regulation of B Cell Functionality by Members of the Tumor Necrosis Factor Superfamily in Jawed Fish

B Cell-Activating Factor Regulates Different Aspects of B Cell Functionality and Is Produced by a Subset of Splenic B Cells in Teleost Fish

Characterization of BAFF and APRIL subfamily receptors in rainbow trout (Oncorhynchus mykiss). Potential role of the BAFF / APRIL axis in the pathogenesis of proliferative kidney disease

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