The Fine-Tuned Release of Antioxidant from Superparamagnetic Nanocarriers under the Combination of Stationary and Alternating Magnetic Fields

Mandić, Lucija; Sadžak, Anja; Erceg, Ina; Baranović, Goran; Šegota, Suzana

doi:10.3390/antiox10081212

Cited by 10 publications

(13 citation statements)

References 60 publications

(94 reference statements)

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“…Thus, this property can enhance anticancer effect where cell death can be achieved through high production of free radicals by myricetin in the proper environment [ 48 ]. In supporting to previous studies, Mandic et al claimed that myricetin contributes to the increase in the toxic effect of copper and increased ROS generation, depleted GSH content, and reduced cell viability of neuroblastoma cells (SH-SY5Y cells) indicating that myricetin might form intercalation with transition metals (iron, copper) and acquires capabilities to induce DNA damage [ 73 ].…”

Section: Prooxidant Activity Of Myricetinsupporting

confidence: 70%

Myricetin: a Multifunctional Flavonol in Biomedicine

Agraharam

Girigoswami

2022

Curr Pharmacol Rep

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Purpose of Reveiw The root cause of many diseases like CVD, cancer, and aging is free radicals which exert their effect by interfering with different metabolic pathways. The sources of free radicals can be exogenous, like UV rays from sunlight, and endogenous due to different metabolic by-products. In our body, there are defense mechanisms present, such as antioxidant enzymes and antioxidant molecules to combat these free radicals, but if there is an overload of these free radicals in our body, the defense system may not be sufficient to neutralize these free radicals. In such situations, we are exposed to a chronic low dose of oxidants creating oxidative stress, which is responsible for eliciting different diseases. Recent Findings Pubmed and Google Scholar are the search engines used to sort out relevant papers on myricetin and its role in combating many diseases. Myricetin is present in many fruits and vegetables and is a known antioxidant. It can elevate the antioxidant enzyme levels; reduces the lipid peroxidation; and is known to protect against cancer. In the case of myocardial dysfunction, myricetin has been shown to suppress the inflammatory cytokines and reduced the mortality rate. Myricetin has also been found to reduce platelet aggregation and control the viral infections by interfering in the DNA replication pathways. Summary In this paper, we have briefly reviewed about the different type and site of free radicals and the role of myricetin in addressing the ROS and different diseases.

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Section: Prooxidant Activity Of Myricetinsupporting

confidence: 70%

Myricetin: a Multifunctional Flavonol in Biomedicine

Agraharam

Girigoswami

2022

Curr Pharmacol Rep

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“…It is well known that Fe3O4 NP can be easily controlled by an external magnetic field [14,15,16], but it is difficult to explore their electric properties due to the powder form of NPs. On the other hand, the nanoparticles bonded on the surface of magnetic cellulose provide an excellent framework for new material with excellent mechanical properties, low density, and alluring electromagnetic properties.…”

Section: Introductionmentioning

confidence: 99%

Magnetic nanocellulose: influence of structural features on conductivity and magnetic properties

et al. 2022

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Magnetic cellulose (MC) is prepared by hydrolysis of iron precursors in an aqueous dispersion of cellulose nanofibres. A thin, flexible film was then prepared by removing the water and drying the sample in a hot press at 110°C followed by the removal of the water. Structural analysis of MC was performed and correlated with the measurement of electromagnetic properties. The magnetic cellulose showed high magnetic saturation of 68 emu/g with characteristic superparamagnetic behaviour, and conductivity in a range of semiconductors, with an increase of DC conductivity with increasing temperature.Modification of cellulose with Fe3O4 has a positive effect on the DC conductivity and lower limit that needs to be exceeded to achieve a stable and sustainable conductivity in the range of 5-20 ×10 -9 (Ω cm) -1 @30 °C is 65 wt% of the Fe3O4 for studied MC composites. The surface roughness of the magnetic cellulose shows a dynamic change with increasing temperature, which is closely related to the enhancement of MC conductivity. A theoretical model of the conductivity is calculated based on continuous 2D percolation and shows an interesting agreement with the experimental results.

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“…The experiments show a very strong inhibition of styrene autoxidation by MAG@phenol, which matches that displayed by unbound phenols, with the exception of gallic acid. Therefore, pseudo core–shell SPION behave as a reservoir of phenols that dissolves in solution and inhibits autoxidation, similar to other systems based on antioxidant loading into nano-scaffolds [ 47 , 48 ]. A possible explanation for the low efficacy of MAG-GA is the slow release of GA in solution.…”

Section: Discussionmentioning

confidence: 99%

Chain-Breaking Antioxidant and Peroxyl Radical Trapping Activity of Phenol-Coated Magnetic Iron Oxide Nanoparticles

et al. 2022

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Superparamagnetic iron oxide nanoparticles (SPION) are important materials for biomedical applications, and phenol capping is a common procedure to passivate their surface. As phenol capped SPION have been reported to behave as antioxidants, herein, we investigate the mechanism underlying this activity by studying the reaction with alkyl peroxyl (ROO•) radicals. SPION were prepared by coprecipitation of Fe(II) and Fe(III), using phenolic antioxidants (gallic acid, Trolox and nordihydroguaiaretic acid) as post-synthesis capping agents and by different purification procedures. The reactivity of ROO• was investigated by inhibited autoxidation studies, using styrene as an oxidizable substrate (solvent MeCN, 30 °C) and azo-bis(isobutyronitrile) as a radical initiator. While unprotected, bare SPION behaved as prooxidant, accelerating the O2 consumption of styrene autoxidation, phenol capping provided a variable antioxidant effect that was dependent upon the purification degree of the material. Thoroughly washed SPION, containing from 7% to 14% (w/w) of phenols, had a low reactivity toward peroxyl radicals, while SPION with a higher phenol content (46% to 55%) showed a strong radical trapping activity. Our results indicate that the antioxidant activity of phenol-capped SPION can be caused by its release in a solution of weakly bound phenols, and that purification plays a major role in determining the properties of these materials.

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The Fine-Tuned Release of Antioxidant from Superparamagnetic Nanocarriers under the Combination of Stationary and Alternating Magnetic Fields

Cited by 10 publications

References 60 publications

Myricetin: a Multifunctional Flavonol in Biomedicine

Myricetin: a Multifunctional Flavonol in Biomedicine

Magnetic nanocellulose: influence of structural features on conductivity and magnetic properties

Chain-Breaking Antioxidant and Peroxyl Radical Trapping Activity of Phenol-Coated Magnetic Iron Oxide Nanoparticles

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