The FGF-21 genetic variants rs838133 and rs838145 are associated with high salt intake in the Emirati population

Saber-Ayad, Maha; Hammoudeh, Sarah; Radwan, Hadia; Manzoor, Shaista; Jabbar, Hussein Ali; Wardeh, Rahaf; Ashraf, Ahmed Bilal; Habib, Peter T.; Alsamman, Alsamman M.; Hamoudi, Rifat

doi:10.1016/j.jare.2020.05.020

Cited by 5 publications

(2 citation statements)

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“…In our study, the Traditional diet, associated with FGF21 rs838133 A allele, was also associated with high sodium intake. Such an association confirmed the findings of an earlier investigation by our group indicating a high preference for salty food among Emiratis ( 47 ). In line with the evidence for a higher sodium consumption for subjects carrying the FGF21 rs838133 A allele, Frayling et al reported that this gene variant is associated with high blood pressure ( 48 ).…”

Section: Discussionsupporting

confidence: 92%

Dietary Patterns and Their Associations With the FTO and FGF21 Gene Variants Among Emirati Adults

et al. 2021

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Purpose: To examine the dietary patterns and their associations with the FTO and FGF21 gene variants among Emirati adults.Methods: Using a cross-sectional design, healthy adult male and female Emiratis (n = 194) were recruited from primary health care centers in Sharjah, UAE. Participants completed a 61-item semi-quantitative food frequency questionnaire. In addition, a saliva sample was obtained for the genetic analysis. Genotyping was performed for FTOrs9939609(A>T), FTOrs9930506(A>G), FGF21 rs838133 (A > G), and FGF21 rs838145 (A > G). Dietary patterns were derived using the principal component analysis. Logistic regression analyses were used to examine the association of dietary patterns with genetic variants.Results: Three dietary patterns were identified: “Western”: consisting of fast food, sweets, and processed meat; “Traditional Emirati” rich in vegetables, traditional Emirati-mixed-dishes and whole dairy; while whole grains, low-fat dairy, and bulgur were components of the “Prudent” pattern. Subjects carrying the A allele of the FTO rs9939609 were 2.41 times more likely to adhere to the Western pattern compared to subjects with genotype TT (OR:2.41; 95%CI:1.05–5.50). Compared with subjects with A/A, those carrying the G allele of the FTO rs9930506 were more likely to follow a Western diet (OR: 2.19; 95%CI: 1.00–4.97). Participants carrying the risk allele (A) of the FGF21 rs838133 were twice more likely to adhere to the Traditional pattern as compared to subjects with genotype GG (OR: 1.9, 95%CI: 1.01–3.57).Conclusions: The findings of this study suggested associations among specific FTO and FGF21 gene variants with dietary patterns among Emirati adults. These findings could be used to inform evidence-based targeted nutrition preventive recommendations, especially those aiming to limit intake of western type foods.

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Section: Discussionsupporting

confidence: 92%

Dietary Patterns and Their Associations With the FTO and FGF21 Gene Variants Among Emirati Adults

et al. 2021

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“…The overall study characteristics are displayed in Table 2 [ 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 , 56 , 57 , 58 , 59 , 60 , 61 , 62 ]. Iran was the most represented country ( n = 55,592, 76.6%).…”

Section: Resultsmentioning

confidence: 99%

Meta-Analysis and Systematic Review of Micro- and Macro-Nutrient Intakes and Trajectories of Macro-Nutrient Supply in the Eastern Mediterranean Region

et al. 2021

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The Eastern Mediterranean Region (EMR) is experiencing a nutrition transition, characterized by the emergence of overnutrition and micro-nutrient deficiencies. No previous study has comparatively examined nutrient intake in adults across countries in the EMR. This review examined the adequacy of nutrients in adults living in the EMR. Moreover, it analyzed the food balance sheets (FBS) for 1961–2018 to identify the trajectory of energy supply from macro-nutrients in the EMR. A systematic search was conducted from January 2012 to September 2020. Only observational studies were retained with a random sampling design. An assessment of the methodological quality was conducted. Levels of nutrient daily intake and their adequacy compared to the daily reference intake of the Institute of Medicine were reported across the region. No studies were identified for half of the region’s countries. Although nutrient energy intake was satisfactory overall, fat and carbohydrate intake were high. Intake of vitamin D, calcium, potassium, zinc, and magnesium were below that recommended. The analysis of the FBS data allowed for the identification of four linear patterns of trajectories, with countries in the EMR best fitting the ‘high-energy-supply from carbohydrate’ group. This systematic review warrants multi-sectorial commitment to optimize nutrient intake.

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Fibroblast growth factor 21 is a hepatokine involved in MASLD progression

Gallego‐Durán,

Ampuero,

Maya‐Miles

et al. 2024

UEG Journal

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AimWe aimed to assess the role of FGF21 in metabolic dysfunction‐associated steatotic liver disease (MASLD) at a multi‐scale level.MethodsWe used human MASLD pathology samples for FGF21 gene expression analyses (qPCR and RNAseq), serum to measure circulating FGF21 levels and DNA for genotyping the FGF21 rs838133 variant in both estimation and validation cohorts. A hepatocyte‐derived cell line was exposed to free fatty acids at different timepoints. Finally, C57BL/6J mice were fed a high‐fat and choline‐deficient diet (CDA‐HFD) for 16 weeks to assess hepatic FGF21 protein expression and FGF21 levels by ELISA.ResultsA significant upregulation in FGF21 mRNA expression was observed in the liver analysed by both qPCR (fold change 5.32 ± 5.25 vs. 0.59 ± 0.66; p = 0.017) and RNA‐Seq (3.5 fold; FDR: 0.006; p < 0.0001) in MASLD patients vs. controls. Circulating levels of FGF21 were increased in patients with steatohepatitis vs. bland steatosis (386.6 ± 328.9 vs. 297.9 ± 231.5 pg/mL; p = 0.009). Besides, sex, age, A‐allele from FGF21, GG genotype from PNPLA3, ALT, type 2 diabetes mellitus and BMI were independently associated with MASH and significant fibrosis in both estimation and validation cohorts. In vitro exposure of Huh7.5 cells to high concentrations of free fatty acids (FFAs) resulted in overexpression of FGF21 (p < 0.001). Finally, Circulating FGF21 levels and hepatic FGF21 expression were found to be significantly increased (p < 0.001) in animals under CDA‐HFD.ConclusionsHepatic and circulating FGF21 expression was increased in MASH patients, in Huh7.5 cells under FFAs and in CDA‐HFD animals. The A‐allele from the rs838133 variant was also associated with an increased risk of steatohepatitis and significant and advanced fibrosis in MASLD patients.

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The FGF-21 genetic variants rs838133 and rs838145 are associated with high salt intake in the Emirati population

Cited by 5 publications

References 42 publications

Dietary Patterns and Their Associations With the FTO and FGF21 Gene Variants Among Emirati Adults

Dietary Patterns and Their Associations With the FTO and FGF21 Gene Variants Among Emirati Adults

Meta-Analysis and Systematic Review of Micro- and Macro-Nutrient Intakes and Trajectories of Macro-Nutrient Supply in the Eastern Mediterranean Region

Fibroblast growth factor 21 is a hepatokine involved in MASLD progression

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