The fetal lung 1: developmental aspects

Laudy, J. A. M.; Wladimiroff, J. W.

doi:10.1046/j.1469-0705.2000.00228.x

Cited by 77 publications

(48 citation statements)

References 54 publications

(66 reference statements)

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“…Physical factors affecting the normal development of the fetal lung is the intrathoracic capacity, the volume of amniotic fluid, the volume and pressure of pulmonary fluid, respiratory movements and blood supply, while transcription and growth factors are involved in the regulation of the process [5]. So, the etiology of PH may involve space-occupying lesions of the chest; skeletal malformations or large defects in the abmended continuation of antibiotic therapy with amoxicillin-clavulanate for two weeks and planning for surgical resection in order to relieve the chronic symptomatology.…”

Section: Discussionmentioning

confidence: 99%

Unilateral pulmonary hypoplasia in an adult patient

Papadopoulos

Misthos

Chorti

et al. 2018

Monaldi Arch Chest Dis

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Pulmonary hypoplasia (PH) is a developmental anomaly of the lung parenchyma, characterized by a decrease in the number and size of airways, alveoli and vessels. We present a case of a 31-year-old patient with a history of chronic productive cough and frequent respiratory infections, who was referred for investigation of abnormal chest x-ray. The combination of chest computed tomography (CT) and bronchoscopy set the diagnosis of left pulmonary hypoplasia and the patient was treated surgically with a left pneumonectomy. PH is usually diagnosed immediately after birth, causing severe respiratory failure with high mortality. The less severe, unilateral forms can possibly survive by causing compensatory hyperinflation of the other lung and remain undiagnosed until adulthood, presenting either asymptomatic or with symptoms of chronic bronchitis and recurrent respiratory infections. Chest CT is considered the imaging technique of choice for the diagnosis and for the differential diagnosis from other congenital or acquired conditions. The treatment is usually conservative, although surgical resection is indicated in cases of severe cystic changes and intense symptomatology.

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Section: Discussionmentioning

confidence: 99%

Unilateral pulmonary hypoplasia in an adult patient

Papadopoulos

Misthos

Chorti

et al. 2018

Monaldi Arch Chest Dis

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“…Insults occurring during the canalicular stage (16-26 weeks of gestation) impair acinar complexity and maturation [23,24]. Hypoplastic lungs have a decreased number of airway generations, with fewer and smaller peripheral air spaces than normal.…”

Section: Discussionmentioning

confidence: 99%

Is There Significant Improvement in Neonatal Outcome after Treating pPROM Mothers with Amnio-Infusion?

Carolis¹,

Romagnoli²,

Santis

et al. 2004

Neonatology

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The aim of this study was to determine the effects of amnio-infusion treatment on fetal and neonatal mortality and neonatal pulmonary development in women with singleton pregnancies and premature rupture of the membranes occurring at a gestational age of <26 weeks and who had severe oligohydramnios. The treated group of 45 consenting women received serial amnio-infusion and was compared with the control group of 44 women who underwent waiting treatment. Our study confirmed a higher number of live births in the treated group, especially in cases with a gestational age at rupture (GAR) of <20 weeks. Furthermore, even if GAR is an important factor for predicting pulmonary hypoplasia, amnio-infusion treatment reduces the probability of pulmonary hypoplasia. In fact, over 20 weeks, amnio-infusion treatment significantly reduces the risk of pulmonary hypoplasia even if normal lung development cannot be guaranteed.

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“…Figure 1 shows where the maximum vascular resistance takes place. The peak in small arteries (<30-μm diameter) localizes the highest resistance at the intra-acinary level (30)(31)(32). There is one other study showing these types of data in a graph, also obtained from the rabbit model (15).…”

Section: Effects Of To In Cdh Do Not Correlatementioning

confidence: 99%

Airway and vascular maturation stimulated by tracheal occlusion do not correlate in the rabbit model of diaphragmatic hernia

et al. 2013

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Background:In animal models of congenital diaphragmatic hernia (CDH), tracheal occlusion (TO) has induced maturation of both airway spaces and vascular structures. Airway and vascular response to TO are assumed to occur in parallel. This study aims to describe and measure the relationship between airway and vascular maturation induced by TO. Methods: A rabbit model of CDH on gestational day (GD) 23 and TO on GD 28 (term = GD 31) has been used. Two study groups have been defined: DH (diaphragmatic hernia) and TO (DH treated with TO). Animals were collected on GD 30 and blood flow data of the pulmonary artery (pulsatility index (PI) and fractional moving blood volume) were ultrasonographically measured. Lung morphometry consisted of measurements of radial alveolar count (RAC) and arterial muscular thickness. results: Animals in the DH group (n = 9) had the worst hemodynamic parameters; their lungs were hypoplastic and had the thickest arterial muscular layer. Animals in the TO group (n = 10) had all these effects reversed. There were no correlations among hemodynamic, airway, and vascular parameters, except for RAC and PI (r = −0.528, P = 0.043). conclusion: Airway and vascular maturation after TO appear to be uncorrelated effects. TO could trigger several pathways that separately regulate airway and vascular responses.

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The fetal lung 1: developmental aspects

Cited by 77 publications

References 54 publications

Unilateral pulmonary hypoplasia in an adult patient

Unilateral pulmonary hypoplasia in an adult patient

Is There Significant Improvement in Neonatal Outcome after Treating pPROM Mothers with Amnio-Infusion?

Airway and vascular maturation stimulated by tracheal occlusion do not correlate in the rabbit model of diaphragmatic hernia

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