The fertility of hypothyroid male mice

Chubb, Curtis; Henry, Laure

doi:10.1530/jrf.0.0830819

Cited by 9 publications

(3 citation statements)

References 12 publications

(16 reference statements)

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“…Impaired viability in D3KO mice may be due to perinatal thyrotoxicosis, as a similar observation has been made in rats and humans (48,49). Concerning the reproductive function of the D3KO mouse, severe hypothyroidism may affect fertility in both sexes, as demonstrated by hyt/hyt mice (50,51). Of note, fertility in the TRH KO mouse, which manifests a milder degree of hypothyroidism that is similar to that in the D3KO mouse, is normal (32).…”

Section: Figurementioning

confidence: 53%

Type 3 deiodinase is critical for the maturation and function of the thyroid axis

Hernández¹,

Martı́nez²,

Fiering³

et al. 2006

Journal of Clinical Investigation

296

249

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Developmental exposure to appropriate levels of thyroid hormones (THs) in a timely manner is critical to normal development in vertebrates. Among the factors potentially affecting perinatal exposure of tissues to THs is type 3 deiodinase (D3). This enzyme degrades THs and is highly expressed in the pregnant uterus, placenta, and fetal and neonatal tissues. To determine the physiological role of D3, we have generated a mouse D3 knockout model (D3KO) by a targeted inactivating mutation of the Dio3 gene in mouse ES cells. Early in life, D3KO mice exhibit delayed 3,5,3′-triiodothyronine (T3) clearance, a markedly elevated serum T3 level, and overexpression of T3-inducible genes in the brain. From postnatal day 15 to adulthood, D3KO mice demonstrate central hypothyroidism, with low serum levels of 3,5,3′,5′-tetraiodothyronine (T4) and T3, and modest or no increase in thyroid-stimulating hormone (TSH) concentration. Peripheral tissues are also hypothyroid. Hypothalamic T3 content is decreased while thyrotropin-releasing hormone (TRH) expression is elevated. Our results demonstrate that the lack of D3 function results in neonatal thyrotoxicosis followed later by central hypothyroidism that persists throughout life. These mice provide a new model of central hypothyroidism and reveal a critical role for D3 in the maturation and function of the thyroid axis.

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Section: Figurementioning

confidence: 53%

Type 3 deiodinase is critical for the maturation and function of the thyroid axis

Hernández¹,

Martı́nez²,

Fiering³

et al. 2006

Journal of Clinical Investigation

296

249

View full text Add to dashboard Cite

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“…Thyroidectomy in immature male rats caused severe inhibition of gametogenesis and Leydig cell development (Chowdury and Arora, 1984;. Hypothyroid male mice were infertile in 1 study (Beamer et al, 1981) but fertile in others (Chubb and Nolan, 1985;Chubb and Henry, 1988). Hypothyroidism had a depressive effect on libido in stallions (Lowe et al, 1975), but no such effect was observed in hypothyroid male rats (Cooke et al, 1991).…”

Section: Hormonal Treatments Aimed At Natural Pregnanciesmentioning

confidence: 99%

Hormonal Treatment of Male Infertility: Promises and Pitfalls

Dama

Rajender

2009

Journal of Andrology

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Approximately 50% of infertility issues are attributable to male factors. A number of different factors may result in similar reductions of sperm count or motility and affect sperm morphology. Not only is the etiology of male infertility difficult to understand, but it is equally challenging to treat male infertility because of its etiological heterogeneity. Because of complex and incomplete knowledge of the underlying causes, most infertile men are described as idiopathically oligozoospermic and/or asthenozoospermic. Different hormonal treatments have been attempted, aiming to improve mainly endogenous follicle-stimulating hormone and/or androgen levels and subsequent spermatogenesis. Various studies have tried to treat infertility through natural pregnancies or increased sperm retrieval for in vitro fertilization techniques, or by treating spermatozoa in vitro to improve its fertilizing potential. The present review focuses on all of the aspects of male infertility treatment by hormone supplementation.

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“…An example might be the relationship between hypothyroidism and infertility. It is possible that this link exists, and there may be sufficient evidence to conclude that there is a relationship between the two, but available data may not be sufficient to establish a statistical model of the relationship (Lincoln et al, 1999;Chubb & Henry, 1988). In many cases, the scientists simply do not know what effects will be seen in humans.…”

Section: Identification Of Health Effectsmentioning

confidence: 99%

Linking Economics and Risk Assessment

Dockins

Griffiths

Owens

et al. 2004

Journal of Toxicology and Environmental Health, Part A

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Benefit-cost analysis relies heavily upon risk assessment. The extent to which benefits can be quantitatively included in an economic analysis is frequently determined by risk assessment methods. Therefore, interdisciplinary collaboration between economists and experts in risk assessment-related disciplines is critical to further development of quantitative human health benefits analysis. To further lay the groundwork for such collaborations, this article reviews the economic foundations of benefit-cost analysis, identifies implications of incorporating this approach into risk assessment, and suggests future cooperation between economists and risk assessors.

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The fertility of hypothyroid male mice

Cited by 9 publications

References 12 publications

Type 3 deiodinase is critical for the maturation and function of the thyroid axis

Type 3 deiodinase is critical for the maturation and function of the thyroid axis

Hormonal Treatment of Male Infertility: Promises and Pitfalls

Linking Economics and Risk Assessment

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