The FEMA GRAS assessment of alicyclic substances used as flavour ingredients

Adams, Timothy B.; Hallagan, J.B.; Putnam, J.M.; Gierke, Taylor; Doull, John; Munro, I.C.; Newberne, Paul M.; Portoghese, Philip S.; Smith, Robert L.; Wagner, Bernard M.; Weil, Carrol S.; Woods, L. A.; Ford, R.A.

doi:10.1016/s0278-6915(96)00051-8

Cited by 50 publications

(18 citation statements)

References 87 publications

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“…In addition, the study implies that peppermint oil can also be used in mixed form with lemon oil for effective fumigations. With respect to the phytochemical residues, the identified major residual compounds such as 1-menthone, menthyl acteate, eucalyptal and eugenol, and their respective oils are generally recognised as safe (GRAS) [33–36]. Accordingly, we study suggests that, peppermint and lemon oils can be considered as safer alternatives for commodity treatments.…”

Section: Discussionmentioning

confidence: 88%

Phytochemical residue profiles in rice grains fumigated with essential oils for the control of rice weevil

et al. 2017

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In the present study, we investigated the fumigant potential of five edible essential oils (EOs) against Sitophilus oryzae and their phytochemical residues in treated grains. Among the tested EOs, peppermint oil proved significantly effective (P ≤ 0.05) on S.oryzae at 400 μl/L air concentration, inducing 83 and 100% mortalities in with-food and without-food conditions respectively over 72 h exposure. In addition, it was also observed that the binary mixtures of peppermint + lemon oil (1:1 ratio) produced an equivalent effect to that of peppermint oil alone treatments. The phytochemical residue analysis by GC-MS revealed the presence of six compounds upon 72 h exposure to EOs. Further, the analysis of physico-chemical properties of the compounds indicated a positive correlation between polar surface area (PSA) and its residual nature. The residue levels of eugenol were significantly elevated corresponding to its high PSA value (29) in clove and cinnamon oils. On the other hand, the compounds with zero PSA value imparted very less or no (D-Limonene, caryophyllene, pinene and terpinolene) residues in treated grains. With respect to the most active peppermint oil, L-menthone, menthyl acetate and eucalyptol residues were at 67, 41 and 23% levels respectively. The outcome of the present study indicate the peppermint oil as a potent fumigant against S. oryzae, and although the residues of phytochemicals in treated grains is higher; they belong to the generally recognised as safe (GRAS) status leaving no harmful effect.

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Section: Discussionmentioning

confidence: 88%

Phytochemical residue profiles in rice grains fumigated with essential oils for the control of rice weevil

et al. 2017

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“…[24][25][26] 27,28 which suggested that 5-hmC could be one of the major oxidative degradation products of 5-mC. However, its oxidative formation could not be confirmed under in vivo condition.…”

Section: The Relationship Between 5-mc and 5-hmcmentioning

confidence: 94%

5-hydroxymethylcytosine

2013

Cancer Biology & Therapy

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“…Early researches demonstrated that 5-hmC may be associated with 5-mC sites in normal DNA in response to oxidative stress. With a series of in vitro studies showing that treatment of 5-mC under UV light or Fenton conditions (Fe 2+/ Cu 2+ and H 2 O 2 ) or with benzoylperoxide in CBrCl 3 can yield 5-hmC [63, 64], it is suggested that 5-hmC might be one of the major oxidative degradation products of 5-mC. However, its oxidative formation cannot be confirmed in in vivo conditions.…”

Section: The Relationship Between 5-mc and 5-hmcmentioning

confidence: 99%

Epigenetic Function of TET Family, 5-Methylcytosine, and 5-Hydroxymethylcytosine in Hematologic Malignancies

2019

Oncol Res Treat

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DNA methylation plays significant roles in a variety of biological and pathological processes including mammalian development, genomic imprinting, retrotransposon silencing, and X-chromosome inactivation. Recent discoveries indicated that ten-eleven translocation (TET) family of dioxygenases can convert 5-methylcytosine (5-mC) into 5-hydroxymethylcytosine (5-hmC). The TET family includes three members: TET1, TET2, and TET3. With increasing evidence, more and more biological and pathological processes in which 5-hmC and TET family serve unparalleled biological roles are noticed, for example, DNA demethylation and transcriptional regulation of different target genes, which are involved in many human diseases, especially hematologic malignancies, resembling chronic myelomonocytic leukemia, myelodysplastic syndromes, and so on. In this review, we focus on the diverse functions of TET family and the novel epigenetic marks, 5-mC and 5-hmC, in hematologic malignancies. This review will provide valuable insights into the potential targets of hematologic malignancies. Further understanding of the normal and pathological functions of TET family may provide new methods to develop novel epigenetic therapies for treating hematologic malignancies.

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The FEMA GRAS assessment of alicyclic substances used as flavour ingredients

Cited by 50 publications

References 87 publications

Phytochemical residue profiles in rice grains fumigated with essential oils for the control of rice weevil

Phytochemical residue profiles in rice grains fumigated with essential oils for the control of rice weevil

5-hydroxymethylcytosine

Epigenetic Function of TET Family, 5-Methylcytosine, and 5-Hydroxymethylcytosine in Hematologic Malignancies

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