5-hydroxymethylcytosine

Ye, Chao; Li, Lan

doi:10.4161/cbt.27144

Cited by 47 publications

(29 citation statements)

References 67 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In the DNA demethylation patterns, 5-hmC can generate 5-fC and 5-caC by TET enzymes, both of which can be removed by TDG via BER pathway [22, 30]. Emerging evidence indicates that 5-mC and 5-hmC might serve unique biological roles in many biological processes such as gene control mechanisms, DNA methylation/dethylation regulation, and are involved in many diseases, especially hematologic malignancies [5, 7, 19]. …”

Section: The Relationship Between 5-mc and 5-hmcmentioning

confidence: 99%

“…However, with the development of molecular biology, research illustrates that epigenetic modifications play more important role in the occurrence and the development of malignancies [5]. Epigenetics, which refers to stable alteration in gene expression, is not a fundamental modification in the genetic sequence, and it is best exemplified by differentiation.…”

Section: -Mc 5-hmc In Human Hematologic Malignanciesmentioning

confidence: 99%

“…The recent discovery of TET proteins, which are capable of converting 5-mC to 5-hmC, may give a great breakthrough to this epigenetic research field [8, 20, 77]. Overall, 5-mC and 5-hmC can participate in the pathogenesis of myeloid malignancies via the disorder of myeloid differentiation, prevention of DNA methylation, and maintenance of gene expression [5]. Malignant transformation seems to be generally associated with decreased level of genomic 5-hmC in different tissues.…”

Section: -Mc 5-hmc In Human Hematologic Malignanciesmentioning

confidence: 99%

“…With the development of these studies, this DNA methylation process moved to a new direction [5]. In 2009, two reports in Science indicated that mammalian genomic DNA contains not only 5-mC but also 5-hmC, which is now widely regarded as the “sixth base” in mammalian genome [7, 8].…”

Section: Introductionmentioning

confidence: 99%

“…The normal movement of life is dependent on the corrected methylation marker loci; however, the disordered marker locus can lead to many diseases, especially hematologic malignancies [28, 29]. Lately, increasing studies pay attention to the correlation between DNA methylation/demethylation and hematologic malignancies [4, 5, 19]. The TET hydroxylases catalyze the conversion of 5-mC to 5-hmC in a 2-OG- and Fe(II)-dependent manner [8, 20].…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Epigenetic Function of TET Family, 5-Methylcytosine, and 5-Hydroxymethylcytosine in Hematologic Malignancies

2019

Oncol Res Treat

View full text Add to dashboard Cite

DNA methylation plays significant roles in a variety of biological and pathological processes including mammalian development, genomic imprinting, retrotransposon silencing, and X-chromosome inactivation. Recent discoveries indicated that ten-eleven translocation (TET) family of dioxygenases can convert 5-methylcytosine (5-mC) into 5-hydroxymethylcytosine (5-hmC). The TET family includes three members: TET1, TET2, and TET3. With increasing evidence, more and more biological and pathological processes in which 5-hmC and TET family serve unparalleled biological roles are noticed, for example, DNA demethylation and transcriptional regulation of different target genes, which are involved in many human diseases, especially hematologic malignancies, resembling chronic myelomonocytic leukemia, myelodysplastic syndromes, and so on. In this review, we focus on the diverse functions of TET family and the novel epigenetic marks, 5-mC and 5-hmC, in hematologic malignancies. This review will provide valuable insights into the potential targets of hematologic malignancies. Further understanding of the normal and pathological functions of TET family may provide new methods to develop novel epigenetic therapies for treating hematologic malignancies.

show abstract

Section: The Relationship Between 5-mc and 5-hmcmentioning

confidence: 99%

Section: -Mc 5-hmc In Human Hematologic Malignanciesmentioning

confidence: 99%

Section: -Mc 5-hmc In Human Hematologic Malignanciesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Epigenetic Function of TET Family, 5-Methylcytosine, and 5-Hydroxymethylcytosine in Hematologic Malignancies

2019

Oncol Res Treat

View full text Add to dashboard Cite

show abstract

DNA hydroxymethylation of colorectal primary carcinoma and its association with survival

Zhong

Tian

Zhang

et al. 2018

Journal of Surgical Oncology

View full text Add to dashboard Cite

show abstract

Human globozoospermia‐related genes and their role in acrosome biogenesis

Moreno

2022

WIREs Mechanisms of Disease

View full text Add to dashboard Cite

The mammalian acrosome is a secretory vesicle attached to the sperm nucleus whose fusion with the overlying plasma membrane is required to achieve fertilization. Acrosome biogenesis starts during meiosis, but it lasts through the entire process of haploid cell differentiation (spermiogenesis). Acrosome biogenesis is a stepwise process that involves membrane traffic from the Golgi apparatus, but it also seems that the lysosome/endosome system participates in this process. Defective sperm head morphology is accompanied by defective acrosome shape and function, and patients with these characteristics are infertile or subfertile. The most extreme case of acrosome biogenesis failure is globozoospermia syndrome, which is primarily characterized by the presence of round‐headed spermatozoa without acrosomes with cytoskeleton defects around the nucleus and infertility. Several genes participating in acrosome biogenesis have been uncovered using genetic deletions in mice, but only a few of them have been found to be deleted or modified in patients with globozoospermia. Understanding acrosome biogenesis is crucial to uncovering the molecular basis of male infertility and developing new diagnostic tools and assisted reproductive technologies that may help infertile patients through more effective treatment techniques. This article is categorized under: Reproductive System Diseases > Environmental Factors Infectious Diseases > Stem Cells and Development Reproductive System Diseases > Molecular and Cellular Physiology

show abstract

5-hydroxymethylcytosine

Cited by 47 publications

References 67 publications

Epigenetic Function of TET Family, 5-Methylcytosine, and 5-Hydroxymethylcytosine in Hematologic Malignancies

Epigenetic Function of TET Family, 5-Methylcytosine, and 5-Hydroxymethylcytosine in Hematologic Malignancies

DNA hydroxymethylation of colorectal primary carcinoma and its association with survival

Human globozoospermia‐related genes and their role in acrosome biogenesis

Contact Info

Product

Resources

About