The fecapentaenes, potent mutagens from human feces

Dg, Kingston; Rl, Van Tassell; Td, Wilkins

doi:10.1021/tx00017a001

Cited by 19 publications

(17 citation statements)

References 52 publications

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“…We might expect Bacteroides species to be highly associated with high risk of colon cancer because consumption of red meat and a high-fat diet is reported to be associated with high risk of colon cancer (2, 3) and fat stimulates bile flow, which in turn specifically stimulates Bacteroides species. This possibility has been supported by studies that show that many strains of Bacteroides species convert bile to metabolites and fecapentaenes, which have been thought to be cocarcinogens or mutagens (9). Only two Bacteroides species, Bacteroides vulgatus and Bacteroides stercoris, showed significant association with high risk as opposed to low risk (Table 4).…”

Section: Discussionmentioning

confidence: 86%

Intestinal floras of populations that have a high risk of colon cancer

Moore

1995

Appl Environ Microbiol

437

185

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The fecal floras of polyp patients, Japanese-Hawaiians, North American Caucasians, rural native Japanese, and rural native Africans were compared. The polyp patients and Japanese-Hawaiians were considered to be groups at high risk of colon cancer, and the rural native Japanese and rural native Africans were considered to be groups at low risk. The North American Caucasians were found to have a flora composition intermediate between these two groups. Fifteen bacterial taxa from the human fecal flora were significantly associated with high risk of colon cancer, and five were significantly associated with low risk of colon cancer. Total concentrations of Bacteroides species and, surprisingly, Bifidobacterium species were generally positively associated with increased risk of colon cancer. Some Lactobacillus species and Eubacterium aerofaciens, which also produces major amounts of lactic acid, showed closest associations with low risk of colon cancer.

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Section: Discussionmentioning

confidence: 86%

Intestinal floras of populations that have a high risk of colon cancer

Moore

1995

Appl Environ Microbiol

437

185

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“…with an increased risk factor for colon cancer, since certain metabolites produced by these microorganisms can be harmful to the host. Additionally, some species such as Bacteroides fragilis are related to the etiology of diarrhea in animals and humans [44,92,93]. …”

Section: Resultsmentioning

confidence: 99%

Effect of a probiotic beverage consumption (Enterococcus faecium CRL 183 and Bifidobacterium longum ATCC 15707) in rats with chemically induced colitis

et al. 2017

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BackgroundSome probiotic strains have the potential to assist in relieving the symptoms of inflammatory bowel disease. The impact of daily ingestion of a soy-based product fermented by Enterococcus faecium CRL 183 and Lactobacillus helveticus 416 with the addition of Bifidobacterium longum ATCC 15707 on chemically induced colitis has been investigated thereof within a period of 30 days.MethodsColitis was induced by dextran sulfate sodium. The animals were randomly assigned into five groups: Group C: negative control; Group CL: positive control; Group CLF: DSS with the fermented product; Group CLP: DSS with the non-fermented product (placebo); Group CLS: DSS with sulfasalazine. The following parameters were monitored: disease activity index, fecal microbial analyses, gastrointestinal survival of probiotic microorganisms and short-chain fatty acids concentration in the feces. At the end of the protocol the animals’ colons were removed so as to conduct a macroscopical and histopathological analysis, cytokines and nitrite quantification.ResultsAnimals belonging to the CLF group showed fewer symptoms of colitis during the induction period and a lower degree of inflammation and ulceration in their colon compared to the CL, CLS and CLP groups (p<0.05). The colon of the animals in groups CL and CLS presented severe crypt damage, which was absent in CLF and CLP groups. A significant increase in the population of Lactobacillus spp. and Bifidobacterium spp. at the end of the protocol was verified only in the CLF animals (p<0.05). This group also showed an increase in short-chain fatty acids (propionate and acetate). Furthermore, the intestinal survival of E. faecium CRL 183 and B. longum ATCC 15707 in the CLF group has been confirmed by biochemical and molecular analyzes.ConclusionsThe obtained results suggest that a regular intake of the probiotic product, and placebo to a lesser extent, can reduce the severity of DSS-induced colitis on rats.

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“…Some species of this genus metabolize substances present in the gut to carcinogens or mutagens 36 and the release of these metabolites may be a risk factor for colon cancer. Besides, some species, such as B. fragilis, are implicated in the etiology of diarrhea in animals and humans.…”

Section: Discussionmentioning

confidence: 99%