The feasibility of <scp>NBI</scp> in patients with suspected upper airway lesions: A multicenter study

Bäck, Leif; Rekola, Jami; Raittinen, Lassi; Halme, Elina; Pietarinen, Petra; Keski-Säntti, Harri; Aaltonen, Leena‐Maija; Mäkitie, Antti; Raappana, Antti; Tikanto, Jukka; Schrey, A; Grénman, Reidar; Laranne, Jussi; Koivunen, Petri; Irjala, Heikki

doi:10.1002/lary.26526

Cited by 3 publications

(13 citation statements)

References 9 publications

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“…21 Of 10 studies that reported sensitivity, the values ranged from 60% to 100% with a median of 73%. Bäck et al 16 and Cohen et al 19 had the largest cohorts with sensitivity rates included.…”

Section: Sensitivitymentioning

confidence: 99%

“…21 PPV and NPV were reported from a total of five studies. PPV ranged between 77% 16 and 100% 7,15 with a median value of 93.5%. NPV ranged between 0% 7 and 100% 16 with a median of 62%.…”

Section: Ppv and Npvmentioning

confidence: 99%

“…PPV ranged between 77% 16 and 100% 7,15 with a median value of 93.5%. NPV ranged between 0% 7 and 100% 16 with a median of 62%. The outlier value (0%) reported by Naidu et al 7 could potentially be explained by their low cohort size (n = 11).…”

Section: Ppv and Npvmentioning

confidence: 99%

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Diagnostic accuracy outcomes of office‐based (outpatient) biopsies in patients with laryngopharyngeal lesions: A systematic review

Owusu-Ayim

Ranjan

Lim

et al. 2022

Clinical Otolaryngology

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Background:In-office biopsies (IOB) using local anaesthetic for laryngopharyngeal tumours has become an increasingly popular approach since the advent of distal chip endoscopes. Although a wide range of studies advocate use in clinical practice, the widespread application of the procedure is hampered by concerns regarding diagnostic accuracy.Objective: To assess the diagnostic accuracy of IOB performed via flexible endoscopy.In addition, to analyse modifiable factors that may affect diagnostic accuracy of IOB.Design: A systematic review following the PRISMA guidelines was conducted.PubMed, EMBASE, the Cochrane Library, Web of Science and CINAHL were used in the literature database search. Quality assessment of included studies was perfomed using the Newcastle-Ottawa Scale.Results: A total of 875 studies were identified, 16 of which were included into the systematic review; 1572 successful biopsies were performed using flexible endoscopy; 1283 cases were accurately diagnosed in the outpatient setting (81.6%) and 289 samples did not provide an accurate diagnosis (18.4%). The median sensitivity of IOB was 73%, and the specificity was 96.7%. Analysis of variable factors did not show any significant differences in method of approach, size of equipment (forceps) and additional lighting system or learning curve. Conclusion:IOB are a viable tool for diagnostic workup of laryngopharyngeal tumours. Clinicians should be wary of reported limitations of IOB when benign or pre-malignant diagnoses are made. In cases suspicious of malignancy, confirmatory investigation should be conducted.

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Section: Sensitivitymentioning

confidence: 99%

“…21 PPV and NPV were reported from a total of five studies. PPV ranged between 77% 16 and 100% 7,15 with a median value of 93.5%. NPV ranged between 0% 7 and 100% 16 with a median of 62%.…”

Section: Ppv and Npvmentioning

confidence: 99%

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Diagnostic accuracy outcomes of office‐based (outpatient) biopsies in patients with laryngopharyngeal lesions: A systematic review

Owusu-Ayim

Ranjan

Lim

et al. 2022

Clinical Otolaryngology

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“…Die Spezifität von 96 % bei WL und NBI zusammen zeigte sich eher vergleichbar zur Spezifität von 95 % bei WL allein. In einer multizentrischen Studie in Hochschulambulanzen in Finnland konnte gezeigt werden, dass die Detektionsrate dysplastischer Läsionen und Karzinomen des oberen Aerodigestivtrakts höher mit NBI als mittels WL-Endoskopie ist [21].…”

Section: Die Eindringtiefe Für Blaues Licht Bei 40 Nm Beträgt Nachunclassified

Endoskopische Frühdiagnostik von Karzinomen im oberen Aerodigestivtrakt

Davaris¹,

Voigt-Zimmermann²,

Cyran³

et al. 2018

Laryngo-Rhino-Otol

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Modern endoscopic imaging techniques make it possible to detect tumor diseases of the upper respiratory and digestive tract and treat them minimally invasive - with a good oncologic outcome and maintaining the functionality of the tissue.Horizontal techniques permit the inspection of big mucous membrane surfaces, searching vor areas suspicious of dysplasia or tumor. They can be used as screening techniques. Vertical techniques serve for precise examination of in-depth expansion, infiltration chraracteristics and dignity of known lesions. Cellular techniques deal with the detection of cellular changes in vivo. As the techniques have different advantages and disandvantages, it is recommended to combine several techniques for best diagnostic gains.

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“…Endoscopic examination is indispensable in the detection and evaluation of laryngopharyngeal lesions . Laryngoscopy is thought to be the most effective tool for the detection of mucosal abnormalities and the evaluation of hypopharyngeal cancer .…”

Section: Introductionmentioning

confidence: 99%

Usefulness of ultrasound for assessing the primary tumor of hypopharyngeal carcinoma

Fukuhara

Matsuda

Hattori

et al. 2017

Laryngoscope Investig Oto

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ObjectivesTo clarify the usefulness of ultrasonography for detecting hypopharyngeal cancer.Study DesignCross‐sectional study.MethodsThe study included 95 patients who underwent pre‐treatment ultrasonography. We evaluated the usefulness of ultrasonography for detecting primary hypopharyngeal carcinoma of each T stage and subsite, and for assessing extrahypopharyngeal invasion. Additionally, we determined the efficacy of color Doppler for evaluating primary hypopharyngeal carcinoma.ResultsThe patients comprised 93 men and 2 women with a mean age of 67.5 years. The T stage (primary tumors) was T1 in 29 patients, T2 in 22, T3 in 9, and T4 in 35. Primary sites with a T stage over T3 were detected using ultrasonography in 17 patients.Regarding primary subsites, postcricoid tumors were assessed most easily (64%), while posterior wall tumors were the most difficult to assess (25%). In 15 of 17 patients, the evaluation of extrahypopharyngeal invasion by ultrasonography matched up precisely with computed tomography findings. In addition, abnormally increased blood flow in primary hypopharyngeal cancers was recognized by color Doppler, and could be used to predict subsites.ConclusionsCancers at T3 and T4 hypopharyngeal primary tumors and their extrahypopharyngeal invasion were detectable using ultrasonography. Furthermore, ultrasonography was useful for assessing postcricoid tumors that were difficult to observe by flexible laryngoscopy.Level of Evidence4

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The feasibility of NBI in patients with suspected upper airway lesions: A multicenter study

Abstract: 2b. Laryngoscope, 127:1821-1825, 2017.

Cited by 3 publications

References 9 publications

Diagnostic accuracy outcomes of office‐based (outpatient) biopsies in patients with laryngopharyngeal lesions: A systematic review

Diagnostic accuracy outcomes of office‐based (outpatient) biopsies in patients with laryngopharyngeal lesions: A systematic review

Endoskopische Frühdiagnostik von Karzinomen im oberen Aerodigestivtrakt

Usefulness of ultrasound for assessing the primary tumor of hypopharyngeal carcinoma

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