The feasibility of low-dose oral lithium therapy and its effect on thyroidal radioiodine uptake, retention, and hormonal parameters in various subcategories of hyperthyroid patients

Chouhan, Arun; Abhyankar, Amit; Basu, Sandip

doi:10.1097/mnm.0000000000000414

Cited by 13 publications

(10 citation statements)

References 14 publications

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“…Lithium has been proposed as an adjunct to radioactive iodine (RAI) for the treatment of hyperthyroidism because lithium inhibits the release of iodine from the thyroid gland [ 35 ] and increases the retention of radioiodine without affecting thyroidal radioiodine uptake [ 36 , 37 ]. Kessler et al conducted a meta-analysis including 2 retrospective cohort studies, 3 randomized controlled trials, and a nonrandomized intervention trial.…”

Section: Current Therapiesmentioning

confidence: 99%

Nonthionamide Drugs for the Treatment of Hyperthyroidism: From Present to Future

Suwansaksri

Preechasuk

Kunavisarut

2018

International Journal of Endocrinology

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Hyperthyroidism is a common endocrine disease. Although thionamide antithyroid drugs are the cornerstone of hyperthyroidism treatment, some patients cannot tolerate this drug class because of its serious side effects including agranulocytosis, hepatotoxicity, and vasculitis. Therefore, nonthionamide antithyroid drugs (NTADs) still have an important role in controlling hyperthyroidism in clinical practice. Furthermore, some situations such as thyroid storm or preoperative preparation require a rapid decrease in thyroid hormone by combination treatment with multiple classes of antithyroid drugs. NTADs include iodine-containing compounds, lithium carbonate, perchlorate, glucocorticoid, and cholestyramine. In this narrative review, we summarize the mechanisms of action, indications, dosages, and side effects of currently used NTADs for the treatment of hyperthyroidism. In addition, we also describe the state-of-the-art in future drugs under development including rituximab, small-molecule ligands (SMLs), and monoclonal antibodies with a thyroid-stimulating hormone receptor (TSHR) antagonist effect.

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Section: Current Therapiesmentioning

confidence: 99%

Nonthionamide Drugs for the Treatment of Hyperthyroidism: From Present to Future

Suwansaksri

Preechasuk

Kunavisarut

2018

International Journal of Endocrinology

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“…When antithyroid drugs are contraindicated, lithium has been proposed; its action mechanism enhances treatment efficacy, allowing lower radioactivity [61,[71][72][73]. Tolerance is satisfactory if contraindications are respected and overdosing is avoided.…”

Section: Preparationmentioning

confidence: 99%

Treatment of adult Graves’ disease

Corvilain

Hamy

Brunaud³

et al. 2018

Annales d'Endocrinologie

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Treatment strategy in Graves' disease firstly requires recovery of euthyroid status by antithyroid therapy. Treatment modalities, precautions, advantages and side-effects are to be discussed with the patient. No particular treatment modality has demonstrated superiority. Pregnancy or pregnancy project affects choice of treatment and monitoring. Graves' orbitopathy is liable to be aggravated by iodine-131 treatment and requires pre-treatment assessment. Iodine-131 treatment aims at achieving hypothyroidism. Thyroid surgery for Graves' disease should preferably be performed by an expert team. In case of recurrence of hyperthyroidism, the various treatment options should be discussed with the patient. Empiric treatment of thyroid dermopathy uses local corticosteroids in occlusive dressing.

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“…Although lithium carbonate has been used in the pharmacotherapy of bipolar disorder for over 60 years [ 1 ], this is minimal use of lithium salts. Much more important is the fact that lithium is necessary for the normal functioning of all body systems and, above all, the nervous system [ 2 ]. Lithium is involved in the metabolism of simple sugars, lipids, regulation of blood pressure and hematopoiesis, regulation of inflammation, in the homeostasis of neurotransmitters, and, in general, exhibits neurotrophic and neuroprotective effects [ 3 ].…”

Section: Introductionmentioning

confidence: 99%

Lithium Ascorbate as a Promising Neuroprotector: Fundamental and Experimental Studies of an Organic Lithium Salt

et al. 2022

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Given the observable toxicity of lithium carbonate, neuropharmacology requires effective and non-toxic lithium salts. In particular, these salts can be employed as neuroprotective agents since lithium ions demonstrate neuroprotective properties through inhibition of glycogen synthetase kinase-3β and other target proteins, increasing concentrations of endogenous neurotrofic factors. The results of theoretical and experimental studies of organic lithium salts presented here indicate their potential as neuroprotectors. Chemoreactomic modeling of lithium salts made it possible to select lithium ascorbate as a suitable candidate for further research. A neurocytological study on cerebellar granular neurons in culture under conditions of moderate glutamate stress showed that lithium ascorbate was more effective in supporting neuronal survival than chloride or carbonate, i.e., inorganic lithium salts. Biodistribution studies indicated accumulation of lithium ions in a sort of “depot”, potentially consisting of the brain, aorta, and femur. Lithium ascorbate is characterized by extremely low acute and chronic toxicity (LD50 > 5000 mg/kg) and also shows a moderate antitumor effect when used in doses studied (5 or 10 mg/kg). Studies on the model of alcohol intoxication in rats have shown that intake of lithium ascorbate in doses either 5, 10 or 30 mg/kg did not only reduced brain damage due to ischemia, but also improved the preservation of myelin sheaths of neurons.

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The feasibility of low-dose oral lithium therapy and its effect on thyroidal radioiodine uptake, retention, and hormonal parameters in various subcategories of hyperthyroid patients

Cited by 13 publications

References 14 publications

Nonthionamide Drugs for the Treatment of Hyperthyroidism: From Present to Future

Nonthionamide Drugs for the Treatment of Hyperthyroidism: From Present to Future

Treatment of adult Graves’ disease

Lithium Ascorbate as a Promising Neuroprotector: Fundamental and Experimental Studies of an Organic Lithium Salt

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