The FCRL3 -169T>C polymorphism is associated with rheumatoid arthritis and shows suggestive evidence of involvement with juvenile idiopathic arthritis in a Scandinavian panel of autoimmune diseases

Abstract

We found an association between the FCRL3 -169T>C SNP and RA, and suggestive evidence for involvement with JIA, in a Norwegian population. These findings lend support for a role for this SNP in RA across ethnically diverse populations, and warrant follow-up studies in JIA.

Polymorphisms in the CTLA-4 Gene and Rheumatoid Arthritis Susceptibility: A Meta-analysis

“…Genetic predisposition has been suggested to be associated with RA risk by numerous case-control studies [30] and meta-analyses [31,32]. CTLA-4 plays important roles in the regulation of the immune responses and pathogenesis of RA.…”

FcRL3 gene promoter variant is associated with peripheral arthritis in Crohnʼs disease

“…46 We were intrigued to examine the relationship between polymorphisms in FcRL3 and IBD because of its role in other autoimmune disorders. While the FcRL3 gene does not appear to play a role in susceptibility to CD or to UC, 33 it is a promising candidate for CD-related seronegative PA, as FcRL3 promoter variants have been associated with the development of inflammatory autoimmune disorders including rheumatoid arthritis, 19,20 juvenile idiopathic arthritis, 22 and different subphenotypes of these diseases. 20 In the present study the minor allele of an FcRL3 promoter variant is significantly associated with the appearance of IBD-related peripheral arthropathy.…”

“…16,17 Association between variants in the Fc receptor-like 3 (FcRL3) gene and RA has been demonstrated in Japanese, 18 -20 Dutch, 21 and Scandinavian populations. 22 In the Scandinavian population, the FcRL3 Ϫ169 polymorphism was associated with a clinical subgroup with polyarticular affection involvement in patients with juvenile idiopathic arthritis. 22 There is also evidence that the chromosomal region to which the FcRL3 gene maps 23 may be a susceptibility locus for several autoimmune diseases including systemic lupus erythematosus, 24 autoimmune thyroid disease, 25 psoriasis, and atopic dermatitis.…”

“…22 In the Scandinavian population, the FcRL3 Ϫ169 polymorphism was associated with a clinical subgroup with polyarticular affection involvement in patients with juvenile idiopathic arthritis. 22 There is also evidence that the chromosomal region to which the FcRL3 gene maps 23 may be a susceptibility locus for several autoimmune diseases including systemic lupus erythematosus, 24 autoimmune thyroid disease, 25 psoriasis, and atopic dermatitis. 26 Because of its association with RA and its location in a chromosomal region linked to other autoimmune disease, the FcRL3 gene is a strong candidate for the pathogenesis of EIMs in IBD, and particularly, of PA.…”

Cutting Edge Issues in Primary Sclerosing Cholangitis

“…1). However, most IBD susceptibility genes tested to date, including those for both UC and CD, have failed to show a common genetic link to PSC [17,28,[32][33][34]. The few exceptions to this are loci at 2q35, 3p21, and 13q31 corresponding to candidate genes takeda G-protein coupled bile acid receptor 5 (TGR5), macrophage stimulating 1 (MST1), and glypican 5 and 6 (GPC5/6), respectively [17,23,[35][36][37].…”